Methods and devices for cryogenic carotid body ablation

• US 9,808,303 B2
• Filed: 08/02/2016
• Issued: 11/07/2017
• Est. Priority Date: 06/01/2012
• Status: Active Grant

• Current Assignee: Cibiem, Inc.
• Original Assignee: Cibiem, Inc.
• Inventors: Ryba, Eric, Gelfand, Mark
• Primary Examiner(s): GIULIANI, THOMAS ANTHONY
• Application Number:
  US15/226,601
• Publication Number:
  US 20160338753A1
• Time in Patent Office: 462 Days
• Field of Search: 606 20- 23, 607 96, 607104, 607105, 607113
• CPC Class Codes: A61B 18/02 by cooling, e.g. cryogenic techniques devices for cooling specific reflex points of the body within cell-life limits A61H39/06
• CPC Class Codes: A61B 18/0218 with open-end cryogenic probe, e.g. for spraying fluid directly on tissue or via a tissue-contacting porous tip
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2018/00041 Heating, e.g. defrosting
• CPC Class Codes: A61B 2018/0022 Balloons
• CPC Class Codes: A61B 2018/00285 Balloons
• CPC Class Codes: A61B 2018/00291 using suction
• CPC Class Codes: A61B 2018/00345 Vascular system
• CPC Class Codes: A61B 2018/00404 Blood vessels other than those in or around the heart
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/0212 using an instrument inserted into a body lumen, e.g. catheter
• CPC Class Codes: A61B 2018/0262 using a circulating cryogenic fluid
• CPC Class Codes: A61B 2018/0293 using an instrument interstitially inserted into the body, e.g. needle
• CPC Class Codes: A61B 2090/376 using X-rays, e.g. fluoroscopy
• CPC Class Codes: A61B 2090/3762 using computed tomography systems [CT]
• CPC Class Codes: A61B 2090/378 using ultrasound
• CPC Class Codes: A61B 2090/3782 transmitter or receiver in catheter or minimal invasive instrument

Abstract

Methods and cryogenic devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via carotid body ablation. Some methods include advancing a cryo-ablation catheter into a patient'"'"'s vasculature and ablating tissue within a carotid septum.

Claims

1. A carotid septum ablation apparatus, comprising:

an elongate shaft, an expandable balloon secured to a distal region of the elongate shaft, a deployable arm adapted to branch from the elongate shaft and extend radially away from a longitudinal axis of the elongate shaft, the expandable balloon adapted to be in fluid communication with an inflation fluid source; and

an elongate member comprising a cryo-ablation member disposed at a distal end of the elongate member, the cryo-ablation member adapted to be in thermal communication with a cryo fluid source to apply thermal energy, the cryo fluid source and the inflation fluid source being different sources, wherein the elongate member and the elongate shaft are adapted so that the elongate member extends radially away from the longitudinal axis of the elongate shaft distal to where the deployable arm branches from the elongate shaft.

2. The apparatus of claim 1, wherein the elongate member is disposed inside the expandable balloon when extending radially away from the longitudinal axis of the elongate shaft.

3. The apparatus of claim 2, wherein the elongate shaft includes a lumen therein in communication with an exit port, the elongate member disposed within the lumen and adapted to be advanced from the exit port into the balloon.

4. The apparatus of claim 1, wherein the elongate member is disposed outside of the expandable balloon when extending radially away from the longitudinal axis of the elongate shaft.

5. The apparatus of claim 1, wherein the elongate member is slidable within a lumen in the elongate shaft.

6. The apparatus of claim 1, wherein the deployable arm is elastic and has a preformed configuration in which it branches from the elongate shaft and extends radially away from the longitudinal axis of the elongate shaft.

7. The apparatus of claim 1, the elongate shaft including an exit port disposed on a same side of the elongate shaft as the deployable arm when extending radially away.

8. The apparatus of claim 7, wherein the exit port is about 4 to about 20 mm distal to a location where the deployable arm extends away from the longitudinal axis of the elongate shaft.

9. The apparatus of claim 1, wherein the elongate member branches from the elongate shaft at an exit port in the elongate shaft.