Fluid extraction or filtration device, associated materials and methods

• US 9,808,377 B2
• Filed: 10/25/2013
• Issued: 11/07/2017
• Est. Priority Date: 02/09/2008
• Status: Active Grant

• Current Assignee: Renephra Limited
• Original Assignee: Renephra Limited
• Inventors: Mitra, Sandip, Brenchley, Paul Ernest Charles, Ulijn, Rein Vincent
• Primary Examiner(s): Ho, Tan-Uyen (Jackie) T
• Assistant Examiner(s): Bryant, Eric
• Application Number:
  US14/063,489
• Publication Number:
  US 20140052084A1
• Time in Patent Office: 1,474 Days
• Field of Search: None
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150091 by electricity
• CPC Class Codes: A61B 5/150358 Strips for collecting blood, e.g. absorbent optical reagent test strips G01N21/8483; chemical reagent test strips G01N33/4875, G01N33/52
• CPC Class Codes: A61B 5/150969 Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
• CPC Class Codes: A61B 5/150984 Microneedles or microblades
• CPC Class Codes: A61B 5/151 Devices specially adapted for taking samples of capillary blood, e.g. by lancets , needles or blades
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61F 13/15203 Properties of the article, e.g. stiffness or absorbency chemical aspects A61L15/00
• CPC Class Codes: A61M 1/14 Dialysis systems; Artificial kidneys; Blood oxygenators semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: A61M 1/3687 Chemical treatment A61M1/3675 takes precedence
• CPC Class Codes: A61M 1/71 Suction drainage systems containers therefor A61M1/60, A61M1/64; negative pressure wound therapy systems A61M1/90
• CPC Class Codes: A61M 2037/003 having a lumen
• CPC Class Codes: A61M 2037/0061 Methods for using microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles

Abstract

A fluid extraction or filtration device for removing fluid from a body, the device comprising an array of microneedles for contacting fluid in said body and an absorbent gel matrix in fluid communication with said array of microneedles. There is further provided a combined fluid extraction and sampling device and methods employing the device(s), for example in determining the level of a target species in a sample of fluid, transdermal dialysis and renal replacement therapy. There is further provided an absorbent gel matrix for use in the treatment of uraemia and a haemodialysis filter comprising an absorbent gel matrix. Use of such a matrix is described in the context of methods including haemodialysis, transdermal dialysis and gastrointestinal dialysis.

Claims

1. A method of treating fluid overload employing a device comprising an array of microneedles for contacting fluid in a body of a patient and an absorbent matrix in fluid communication with said array of microneedles, the method comprising

contacting said fluid with said array of microneedles such that said fluid flows from said body to said absorbent matrix via said microneedles;

and

removing fluid from the body of the patient at a rate of at least 10 ml/day and up to 1000 ml/day.

2. The method according to claim 1 wherein the fluid overload results from renal failure or cardiac failure.

3. The method according to claim 1 wherein said method treats salt and water overload in said patient.

4. The method according to claim 1 wherein fluid is removed from the body of the patient at a rate of at least 50 ml/day.

5. The method according to claim 1 wherein fluid is removed from the body of the patient at a rate of at least 100 ml/day.

6. The method according to claim 1 wherein the method further comprises use of a vacuum suction device to accelerate the flow of fluid from said body to said absorbent matrix via said microneedles.

7. The method according to claim 1 wherein the method further comprises using reverse iontophoresis to aid the flow of fluid from said body to said absorbent matrix via said microneedles.

8. The method according to claim 1 wherein the absorbent matrix is a gel.

9. The method according to claim 1 wherein an osmotic gradient is established between the fluid and the absorbent matrix such that said fluid flows, by osmosis, from said body to said absorbent matrix via said microneedles.

10. The method according to claim 1 wherein the absorbent matrix is dry prior to contacting the fluid.

11. The method according to claim 1 wherein the absorbent matrix exhibits an ability to entrap up to 30 times its own weight of water.

12. The method according to claim 1 wherein the absorbent matrix exhibits an ability to entrap water of up to 90% w/w.

13. The method according to claim 1 wherein said fluid comprises a target species, said patient being in need of having said target species removed from said fluid and said target species being retained in said absorbent matrix.

14. The method according to claim 13 wherein said target species is selected from the group consisting of water, a uraemic toxin, a metabolic product, a salt and an ion.

15. The method according to claim 13 wherein said target species is selected from the group consisting of Retinol Binding Protein, beta-2-Microglobulin, Parathyroid hormone, Adrenomedullin, Atrial Natriuretic Peptide, Asymmetric dimethylarginine, Indole-3-Acetic acid, Uric acid, Homocysteine, Creatine, Creatinine, P-Cresol, Oxalate, Urea and Phosphate.

16. The method according to claim 1 wherein the method is used for treatment of uraemia;

and wherein said patient suffers from uraemia; and

wherein said fluid that flows from said body to said absorbent matrix via said microneedles contains one or more uraemic toxin.

17. A method for transdermal dialysis employing a device comprising an array of microneedles for contacting fluid in a body of a patient in need of dialysis and an absorbent matrix in fluid communication with said array of microneedles, the method comprising:

contacting said fluid with said array of microneedles such that fluid flows from said body to said absorbent matrix via said microneedles, and

removing fluid from the body of the patient at a rate of at least 10 ml/day and up to 1000 ml/day.

18. A method for renal replacement therapy comprising transdermal dialysis employing a device comprising an array of microneedles for contacting fluid in a body of a patient in need of renal replacement therapy and an absorbent matrix in fluid communication with said array of microneedles, the method comprising:

contacting said fluid with said array of microneedles such that fluid flows from said body to said absorbent matrix via said microneedles, and

removing fluid from the body of the patient at a rate of at least 10 ml/day and up to 1000 ml/day.