Treatment of heart disease
First Claim
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1. A method of treating cardiac stem cells to be administered to a subject in need thereof, comprising:
- a. contacting a population of cardiac stem cells with an effective amount of IGF-2or a variant thereof;
b. administering the population of cardiac stem cells from step (a) to the subject in need thereof;
wherein the effective amount of IGF-2 or a variant thereof is sufficient to increase expression of at least one marker for myocyte differentiation by at least about 10%, as compared to cardiac stem cells in the absence of IGF-2 or a variant thereof.
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Abstract
Disclosed herein are methods, compositions and kits for treating cardiac stem cells to be administered to a subject in need thereof, e.g., with a damaged myocardium. The methods, composition and kits of the invention can be used to treat cardiovascular diseases such as heart failure, myocardial infarction and an age-related cardiomyopathy.
38 Citations
16 Claims
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1. A method of treating cardiac stem cells to be administered to a subject in need thereof, comprising:
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a. contacting a population of cardiac stem cells with an effective amount of IGF-2or a variant thereof; b. administering the population of cardiac stem cells from step (a) to the subject in need thereof; wherein the effective amount of IGF-2 or a variant thereof is sufficient to increase expression of at least one marker for myocyte differentiation by at least about 10%, as compared to cardiac stem cells in the absence of IGF-2 or a variant thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification