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Induced hepatocytes and uses thereof

  • US 9,808,490 B2
  • Filed: 11/25/2015
  • Issued: 11/07/2017
  • Est. Priority Date: 11/26/2014
  • Status: Active Grant
First Claim
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1. A method of inducing a trophoblast stem (TS) cell to differentiate into an induced hepatocyte in vitro, comprising:

  • contacting the trophoblast stem cell with a fibroblast growth factor (FGF) that binds to FGFR1 to induce formation of a definitive endoderm (DE) cell, andcontacting the DE cell with a medium to induce differentiation into an induced hepatocyte,wherein the medium comprises a FGF that binds to FGFR1, a glucocorticoid steroid, and an interleukin 6 group cytokine.

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