Noise suppression in an optoacoustic system

• US 9,814,394 B2
• Filed: 03/15/2013
• Issued: 11/14/2017
• Est. Priority Date: 11/02/2011
• Status: Active Grant

• Current Assignee: Seno Medical Instruments, Inc.
• Original Assignee: Seno Medical Instruments, Inc.
• Inventors: Schmid, Gregory
• Primary Examiner(s): SIRIPURAPU, RAJEEV P
• Application Number:
  US13/842,323
• Publication Number:
  US 20130281819A1
• Time in Patent Office: 1,705 Days
• Field of Search: 600407, 600424
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/72 Signal processing specially adapted for physiological signals or for diagnostic purposes character recognition, recognising digital ink, document-oriented image-based pattern recognition G06V30/00; recognition or understanding of postal images G06V30/424
• CPC Class Codes: A61B 8/4281 characterised by sound-transmitting media or devices for coupling the transducer to the tissue

Abstract

An optoacoustic imaging system includes an ultrasound transducer array, first and second light sources and a switching power supply that generates power for the light sources. The switching power supply includes an input for impeding its switching operation. A data acquisition unit samples the ultrasound transducer array for a first predetermined period of time after a pulse of light from the first light source and for a second predetermined period of time after a pulse of light from the second light source and stores the sampled data. A master processor utilizes the input to impede operation of the switching operation of the switching power supply during the first predetermined period of time after a pulse of light from the first light source, and during the second predetermined period of time after a pulse of light from the second light source.

Claims

1. An optoacoustic imaging system comprising:

a handheld probe having a distal end and a proximal end, the handheld probe comprising an ultrasound transducer array having an active end located at the distal end of the handheld probe, the ultrasound transducer array capable of receiving an optoacoustic return signal during an acquisition period and generating data signals corresponding to the optoacoustic return signal, the handheld probe further comprising an optical window located at the distal end of the handheld probe;

one or more light sources having a common output, the one or more light sources configured to generate pulses of light to produce first light events at a first predominant wavelength and to produce second light events at a second predominant wavelength;

one or more sync detectors configured to generate a first sync signal upon detection of a pulse of light at the first predominant wavelength and to generate a second sync signal upon detection of a pulse of light at the second predominant wavelength;

a switching power supply generating power for the one or more light sources, the switching power supply configured to impede power to the one or more light sources upon receipt of a blanking input;

a light path configured to direct light from the common output to the optical window of the handheld probe;

a data acquisition unit configured to sample the data signals during a first data acquisition period and to store the sampled data signals, wherein the first data acquisition period is less than about one percent (1%) of the first light event period; and

a master processor configured to provide the blanking input to the switching power input to impede power to the one or more light sources during a data acquisition period upon receipt of the first sync signal or the second sync signal to cause the optoacoustic imaging system to produce a plurality of light event sequences, each of the light event sequences comprising (i) a first light event at the first predominant wavelength, (ii) a first light event period comprising a first data acquisition period following the first light event, and (iii) a second light event at the second predominant wavelength.

2. The optoacoustic imaging system of claim 1,

wherein the data acquisition unit is further configured to sample the data signals during a second data acquisition period and to store the sampled data signals, wherein the second data acquisition period is less than about one percent (1%) of a second light event period, and

wherein the master processor is further configured to provide the blanking input to the switching power supply to impede power to a first light source and a second light source during the second data acquisition period so as to produce a light event sequence further comprising a second light event period comprising the second data acquisition period following the second light event.

3. The optoacoustic imaging system of claim 2, wherein the first and second data acquisition periods are equal periods of time.

4. The optoacoustic imaging system of claim 2, wherein the first and second data acquisition periods are not equal periods of time.

5. The optoacoustic imaging system of claim 1, wherein the master processor is further configured to control the optoacoustic imaging system, such that the light event sequence includes a set of operations comprising:

pulsing a first light source during the first light event,

initiating sampling by the data acquisition unit during the first data acquisition period,

providing the blanking input to the switching power supply to impede power to the first light source and a second light source during the first data acquisition period, and

pulsing the second light source during the second light event.

6. The optoacoustic imaging system of claim 3, wherein the first and second data acquisition periods are less than about 100 μ

s.

7. The optoacoustic imaging system of claim 3, wherein the first and second data acquisition periods are less than about 65 μ

s.

8. The optoacoustic imaging system of claim 4, wherein the first data acquisition period is less than about 65 μ

s and the second data acquisition period is less than about 63 μ

s.

9. The optoacoustic imaging system of claim 1, wherein the first light event period is about 100 ms and the first data acquisition period is less than about 100 μ

s.

10. The optoacoustic imaging system of claim 1, wherein the first light event period is about 100 ms and the first data acquisition period is less than about 65 μ

s.

11. The optoacoustic imaging system of claim 1, wherein the first light event period is about 50 ms and the first data acquisition period is less than about 100 μ

s.

12. The optoacoustic imaging system of claim 1, wherein the first light event period is about 50 ms and the first data acquisition period is less than about 65 μ

s.

13. The optoacoustic imaging system of claim 1, wherein the first data acquisition period is delayed for a predetermined time period after the first light event.

14. The optoacoustic imaging system of claim 1, wherein the predetermined time period is less than or equal to about 10 μ

s.

15. The optoacoustic imaging system of claim 1, wherein the first light event period is about 50 ms and the first data acquisition period is delayed for a predetermined time period of about 5 μ

s after the first light event.

16. The optoacoustic imaging system of claim 1, wherein the first light event period is about 50 ms and the first data acquisition period is delayed for a predetermined time period of about 7 μ

s after the first light event.

17. The optoacoustic imaging system of claim 1, wherein the first light event has a pulse width greater than about 7 ns.

18. The optoacoustic imaging system of claim 17, wherein the first light event has a pulse width less than about 25 ns.

19. The optoacoustic imaging system of claim 17, wherein the second light event has a pulse width less than about 60 ns.