Long-term implantable monitoring system and methods of use
First Claim
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1. A method of measuring a level of analyte in body fluid, comprising:
- implanting a monitoring system into a body of a patient, the implanted monitoring system having a first multi-layer porous membrane, a second multi-layer porous membrane, and a sensor, the monitoring system further comprising a catheter, the first multi-layer porous membrane forming a wall of the catheter;
creating an ultra-filtrate from a body fluid by imparting a pressure differential to filter a portion of the body fluid through the first multi-layer porous membrane of the implanted monitoring system, the first multi-layer porous membrane having an outer layer and an inner layer, the outer layer having larger pores than the inner layer;
measuring an amount of analyte in the ultra-filtrate with the sensor of the implanted monitoring system; and
returning the ultra-filtrate to the body fluid through the second multi-layer porous membrane.
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Abstract
Methods and systems include a long-term implantable ultra-filtrate monitoring system that uses micro-porous membranes to produce an ultra-filtrate of tissue interstitial fluid or blood plasma. The ultra-filtrate is transported through a sensor to detect a level of analyte in the ultra-filtrate. The long-term implantable fluid monitoring system thus includes a first porous catheter, a second porous catheter, a sensor configured to measure an amount of analyte in fluid, and a pump configured to move fluid through the first porous catheter to the sensor and from the sensor through the second porous catheter.
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Citations
18 Claims
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1. A method of measuring a level of analyte in body fluid, comprising:
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implanting a monitoring system into a body of a patient, the implanted monitoring system having a first multi-layer porous membrane, a second multi-layer porous membrane, and a sensor, the monitoring system further comprising a catheter, the first multi-layer porous membrane forming a wall of the catheter; creating an ultra-filtrate from a body fluid by imparting a pressure differential to filter a portion of the body fluid through the first multi-layer porous membrane of the implanted monitoring system, the first multi-layer porous membrane having an outer layer and an inner layer, the outer layer having larger pores than the inner layer; measuring an amount of analyte in the ultra-filtrate with the sensor of the implanted monitoring system; and returning the ultra-filtrate to the body fluid through the second multi-layer porous membrane. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification