Antimicrobial gas impregnating devices and methods

• US 9,814,623 B2
• Filed: 06/29/2010
• Issued: 11/14/2017
• Est. Priority Date: 09/21/2007
• Status: Active Grant

• Current Assignee: Enox (Israel) LTD
• Original Assignee: Enox (Israel) LTD
• Inventors: Av-Gay, Yossef, Greenberg, David
• Primary Examiner(s): GILBERT, ANDREW M
• Application Number:
  US12/825,373
• Publication Number:
  US 20100268149A1
• Time in Patent Office: 2,695 Days
• CPC Class Codes: A61F 11/202 Surgical middle-ear ventilation or drainage, e.g. permanent; Implants therefor
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61L 2300/114 Nitric oxide, i.e. NO
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/45 Mixtures of two or more drugs, e.g. synergistic mixtures
• CPC Class Codes: A61L 2430/14 for ear reconstruction or ear implants, e.g. implantable hearing aids
• CPC Class Codes: A61L 31/04 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 27/002 Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/06 for tuberculosis

Abstract

A nitric oxide gas-releasing conduit configured for surgical implantation through a patient'"'"'s tympanic membrane. The nitric oxide gas-releasing conduit comprises a gas-permeable cured resin material configured for releasably sequestering therein gas. The gas-permeable cured resin material is charged with nitric oxide gas. The nitric oxide gas-releasing conduit may be optionally coated with an antimicrobial gas-releasing composition. The gas-releasing coating composition may be configured to release nitric oxide.

Claims

1. An antimicrobial gas-releasing conduit comprising an elongate hollow tube that is sufficiently flexible to be implantable within a patient, which tube comprises a gas-permeable cured resin material having a porous microstructure, wherein the porous microstructure of said gas-permeable cured resin material is saturated throughout with antimicrobial gaseous nitric oxide and is devoid of an antimicrobial gas-releasing composition, the conduit being configured such that the gaseous nitric oxide is releasably sequestered in said porous microstructure and thus is released, after implantation of the conduit within a patient, so as to diffuse about the tube and provide antimicrobial gas to the surrounding tissue.

2. The antimicrobial gas-releasing conduit of claim 1, wherein said gas-permeable cured resin material is selected from the group consisting of curable silicones, polyvinyl acetates, acrylonitrile-butadiene-styrene copolymer rubber and polyurethanes.

3. The antimicrobial gas-releasing conduit of claim 1, wherein said elongate hollow tube, that is sufficiently flexible to be implantable within a patient, is an ear-draining tube.

4. The antimicrobial gas-releasing conduit of claim 1, wherein said elongate hollow tube, that is sufficiently flexible to be implantable within a patient, is a tympanostomy tube.

5. The antimicrobial gas-releasing conduit of claim 1, wherein said elongate hollow tube, that is sufficiently flexible to be implantable within a patient, is a myringotomy tube.

6. A method for treating otitis media in a patient comprising implanting the antimicrobial gas-releasing conduit of claim 1 in a patient'"'"'s tympanic membrane.

7. The method of claim 6, wherein said antimicrobial gas-releasing conduit is a tympanostomy tube.

8. The method of claim 6, wherein said antimicrobial gas-releasing conduit is a myringotomy tube.