Methods and compositions for treating bacterial infection

• US 9,814,719 B2
• Filed: 10/26/2016
• Issued: 11/14/2017
• Est. Priority Date: 05/02/2012
• Status: Active Grant

• Current Assignee: Nanova Inc., Curators of the University of Missouri (University of Missouri)
• Original Assignee: Curators of the University of Missouri (University of Missouri)
• Inventors: Sun, Hongmin, Anderson, David W., Li, Lianhai
• Primary Examiner(s): Leeser, Erich A
• Application Number:
  US15/335,156
• Publication Number:
  US 20170056405A1
• Time in Patent Office: 384 Days
• CPC Class Codes: A61K 31/517 ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/527 spiro-condensed
• CPC Class Codes: A61K 31/5377 not condensed and containing further heterocyclic rings, e.g. timolol
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

The present disclosure relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present disclosure provides compounds as therapeutic agents against bacterial infections (e.g., biofilms). The present disclosure also provides compounds as therapeutic agents in methods for treating pneumonia, methods for reducing bacterial virulence, methods for treating a bacterial wound infection, and methods for treating a urinary tract infection. The present disclosure also provides methods for treating a bacterial infection, wherein the bacterial infection has or is suspected of having an antibiotic-resistant bacteria. The present disclosure also provides surfaces coated with the chemical compounds disclosed herein.

Claims

1. A composition comprising:

a compound having the structure of Formula V

2. The composition of claim 1, wherein the compound is selected from the group consisting of:

3. A method for treating pneumonia in a subject in need thereof, the method comprising:

administering a composition comprising a compound of Formula V

4. The method of claim 3, wherein the compound is selected from the group consisting of

5. The method of claim 3, further comprising administering an antibiotic.

6. A method for reducing bacterial virulence in a subject in need thereof, the method comprising:

administering a composition comprising a compound of Formula V

7. The method of claim 6, wherein the compound is selected from the group consisting of

8. The method of claim 6, further comprising administering an antibiotic.

9. A method for treating a bacterial wound infection in a subject in need thereof, the method comprising:

administering a composition comprising a compound of Formula V

10. The method of claim 9, wherein the compound is selected from the group consisting of

11. The method of claim 9, further comprising administering an antibiotic.

12. A method for treating a urinary tract infection in a subject in need thereof, the method comprising:

administering a composition comprising a compound of Formula V

13. The method of claim 12, wherein the compound is selected from the group consisting of

14. The method of claim 12, further comprising administering an antibiotic.

15. A method for treating a bacterial infection, wherein the bacterial infection has or is suspected of having an antibiotic-resistant bacteria, the method comprising:

administering a composition comprising a compound of Formula V

16. The method of claim 15, wherein the compound is selected from the group consisting of

17. A surface coated with a composition comprising a compound of Formula V

18. The surface of claim 17, wherein the compound is selected from the group consisting of

19. The surface of claim 17, wherein the surface is a surface of a medical device.