Systems and methods for providing therapy using electrical stimulation to disrupt neuronal activity

• US 9,814,881 B2
• Filed: 09/22/2015
• Issued: 11/14/2017
• Est. Priority Date: 09/22/2014
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Moffitt, Michael A.
• Primary Examiner(s): MAHMOOD, NADIA AHMAD
• Application Number:
  US14/861,664
• Publication Number:
  US 20160082257A1
• Time in Patent Office: 784 Days
• Field of Search: 607 46, 607118
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36135 using physiological parameters
• CPC Class Codes: A61N 1/36139 with automatic adjustment

Abstract

An electrical stimulation system includes an implantable control module having a processor. The control module provides electrical stimulation signals to one or more leads coupled to the control module for stimulation of patient tissue to treat pain. A first electrode is disposed on the one or more leads in the patient'"'"'s spinal cord and communicates with the processor to generate a first effective electric field suitable for stimulating patient tissue using the electrical stimulation signals provided from the control module. A second electrode is disposed on the one or more leads and communicates with the processor to generate a second effective electric field suitable for stimulating patient tissue using the electrical stimulation signals provided from the control module. The second effective electric field is time-delayed from the first effective electric field such that the second effective electric field is out of phase with the first effective electric field.

Claims

1. An electrical stimulation system, comprising:

an implantable control module configured and arranged for implantation in a body of a patient and comprising a processor, wherein the control module is configured and arranged to provide electrical stimulation signals to a plurality of electrodes electrically-coupled to the control module and configured and arranged for electrical stimulation of patient tissue to treat patient pain;

a first electrode disposed on at least one electrical stimulation lead in a spinal cord of the patient, wherein the processor is configured and arranged to generate a first effective electric field suitable for stimulating patient tissue using the first electrode and the electrical stimulation signals provided from the control module;

a second electrode disposed on the at least one electrical stimulation lead in the spinal cord of the patient, wherein the processor is configured and arranged to generate a second effective electric field suitable for stimulating patient tissue using the second electrode and the electrical stimulation signals provided from the control module, wherein the processor is configured and arranged to generate the second effective electric field time-delayed from the first effective electric field such that the second effective electric field is out of phase with the first effective electric field; and

a sensor in communication with the processor, the sensor configured and arranged for monitoring patient theta-band activity and detecting frequency shifts, wherein the processor is configured and arranged to generate the first and second effective electric fields using the first and second electrodes in response to a shift in frequency of the theta-band activity detected by the sensor.

2. The electrical stimulation system of claim 1, wherein the processor is configured and arranged for determining the time delay between the first effective electric field and the second effective electric field based on the first detected shift in frequency of the theta-band activity.

3. The electrical stimulation system of claim 1, wherein the processor is configured and arranged to generate the first and second effective electric fields only when the shift in frequency of the theta-band activity is at least 0.5 Hz.

4. The electrical stimulation system of claim 1, wherein the processor is configured and arranged to adjust at least one of amplitude, frequency, impedance, voltage, or pulse width of the electrical stimulation signals provided to the first electrode and the second electrode in response to the sensor detecting another shift in frequency of the theta-band activity.

5. The electrical stimulation system of claim 1, wherein the processor is configured and arranged to terminate the electrical stimulation signals provided to the first electrode and the second electrode in response to the sensor detecting another in frequency of the theta-band activity.

6. The electrical stimulation system of claim 1, further comprising a computer model in communication with the processor, the computer model configured and arranged for coordinating with the processor to facilitate the positioning of the first electrode and the second electrode in the spinal cord of the patient.

7. The electrical stimulation system of claim 1, further comprising a computer model in communication with the processor, the computer model configured and arranged for coordinating with the processor to adjust at least one of amplitude, frequency, impedance, voltage, or pulse width of at least one of the first effective electric field or the second effective electric field.

8. The electrical stimulation system of claim 1, further comprising an actuator located external to the patient and in communication with the processor, the actuator configured and arranged for causing the control module to initiate providing the electrical stimulation signals to the at least one electrical stimulation lead.

9. The electrical stimulation system of claim 1, further comprising an actuator located external to the patient and in communication with the processor, the actuator configured and arranged for causing the control module to terminate providing the electrical stimulation signals to the at least one electrical stimulation lead.

10. An electrical stimulation system, comprising:

an implantable control module configured and arranged for implantation in a body of a patient and comprising a processor, wherein the control module is configured and arranged to provide electrical stimulation signals to at least one electrical stimulation lead coupled to the implantable control module for stimulation of patient tissue to treat patient pain;

a first electrode disposed on at least one electrical stimulation lead in a spinal cord of the patient, wherein the processor is configured and arranged to generate a first effective electric field suitable for stimulating patient tissue using the first electrode and the electrical stimulation signals provided from the control module;

a second electrode disposed on the at least one electrical stimulation lead in the spinal cord of the patient, wherein the processor is configured and arranged to generate a second effective electric field suitable for stimulating patient tissue using the second electrode and the electrical stimulation signals provided from the control module, wherein the processor is configured and arranged to generate the first and second effective electric fields using the first and second electrodes so that the second effective electric field has an overlap in volume of no more than 20% with the first effective electric field; and

a sensor in communication with the processor, the sensor configured and arranged for monitoring patient theta-band activity and detecting frequency shifts.

11. The electrical stimulation system of claim 10, wherein the processor is configured and arranged to generate the first and second effective electric fields using the first and second electrodes so that the second effective electric field does not overlap in volume with the first effective electric field.

12. The electrical stimulation system of claim 10, further comprising a computer model in communication with the processor, the computer model configured and arranged for coordinating with the processor to facilitate the positioning of the first electrode and the second electrode in the spinal cord of the patient such that the second effective electric field has an overlap in volume of no more than 20% with the first effective electric field.

13. The electrical stimulation system of claim 10, further comprising a computer model in communication with the processor, the computer model configured and arranged for coordinating with the processor to adjust at least one of amplitude, frequency, impedance, voltage, or pulse width of at least one of the first effective electric field or the second effective electric field such that the second effective electric field has an overlap in volume of no more than 20% with the first effective electric field.

14. An electrical stimulation system, comprising:

an implantable control module configured and arranged for implantation in a body of a patient and comprising a processor, wherein the control module is configured and arranged to provide electrical stimulation signals to at least one electrical stimulation lead coupled to the implantable control module for stimulation of patient tissue to treat patient pain;

a first electrode disposed on at least one electrical stimulation lead in a spinal cord of the patient, wherein the processor is configured and arranged to generate a first effective electric field suitable for stimulating a first set of target neurons within patient tissue using the first electrode and the electrical stimulation signals provided from the control module;

a second electrode disposed on the at least one electrical stimulation lead in the spinal cord of the patient, wherein the processor is configured and arranged to generate a second effective electric field suitable for stimulating a second set of target neurons that is different from the first set of target neurons within patient tissue using the second electrode and the electrical stimulation signals provided from the control module, wherein the processor is configured and arranged to generate the first and second effective electric fields using the first and second electrodes so that the second effective electric field has an overlap in volume of at least 50% with the first effective electric field; and

a sensor in communication with the processor, the sensor configured and arranged for monitoring patient theta-band activity and detecting frequency shifts.

15. The electrical stimulation system of claim 14, wherein the second set of target neurons is a subset of the first set of target neurons.

16. The electrical stimulation system of claim 14, wherein the second set of target neurons is mutually exclusive of the first set of target neurons.