Stimulation electrode selection
First Claim
1. A method comprising:
- sensing a plurality of bioelectrical signals in a brain of a patient with respective sense electrode combinations that each comprise at least one electrode;
selecting one of the sense electrode combinations based on a signal characteristic of each of the sensed bioelectrical signals, the signal characteristic indicating a location of the at least one electrode of the respective sense electrode combination relative to a target tissue site;
accessing a physiological model that indicates one or more characteristics of tissue proximate the at least one electrode within the brain of the patient; and
selecting, based on the signal characteristic of the bioelectrical signal sensed with the selected sense electrode combination and the physiological model, a stimulation electrode combination for delivering electrical stimulation to the brain of the patient.
1 Assignment
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Accused Products
Abstract
One or more stimulation electrodes may be selected based on a bioelectrical signal sensed in a brain of a patient with a sense electrode combination that comprises at least one electrode and a physiological model that indicates one or more anatomical structures of the brain of the patient that are proximate the implanted at least one electrode. In some examples, the bioelectrical brain signal indicates which electrodes are located closest to a target tissue site. The physiological model can be generated based on a location of implanted at least one electrode within a patient and patient anatomy data, which can, for example, indicate one or more characteristics of patient tissue proximate to the implanted at least one electrode. In some example, the physiological model includes a therapy field model that represents a region of the tissue of the patient to which therapy is delivered via a selected set of electrodes.
104 Citations
34 Claims
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1. A method comprising:
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sensing a plurality of bioelectrical signals in a brain of a patient with respective sense electrode combinations that each comprise at least one electrode; selecting one of the sense electrode combinations based on a signal characteristic of each of the sensed bioelectrical signals, the signal characteristic indicating a location of the at least one electrode of the respective sense electrode combination relative to a target tissue site; accessing a physiological model that indicates one or more characteristics of tissue proximate the at least one electrode within the brain of the patient; and selecting, based on the signal characteristic of the bioelectrical signal sensed with the selected sense electrode combination and the physiological model, a stimulation electrode combination for delivering electrical stimulation to the brain of the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method comprising:
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sensing a bioelectrical signal in a brain of a patient with a sense electrode combination that comprises at least one electrode; accessing a physiological model that indicates one or more characteristics of tissue proximate the at least one electrode within the brain of the patient; selecting, based on a signal characteristic of the bioelectrical signal, a stimulation electrode combination for delivering electrical stimulation to the brain of the patient, the signal characteristic indicating a location of the at least one electrode relative to a target tissue site; and confirming the stimulation electrode combination based on the physiological model. - View Dependent Claims (13, 14)
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15. A method comprising:
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sensing a plurality of bioelectrical signals in a brain of a patient with respective sense electrode combinations that each comprise at least one electrode; selecting one of the sense electrode combinations based on a signal characteristic of each of the sensed bioelectrical signals, the signal characteristic indicating a location of the at least one electrode of the respective sense electrode combination relative to a target tissue site; accessing a physiological model that indicates one or more characteristics of tissue proximate the at least one electrode within the brain of the patient; selecting, based on the physiological model, a stimulation electrode combination for delivering electrical stimulation to the brain of the patient; and confirming the selected stimulation electrode combination based on the signal characteristic of the bioelectrical signal sensed with the selected sense electrode combination. - View Dependent Claims (16)
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17. A system comprising:
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a sensing module configured to sense a plurality of bioelectrical signals in a brain of a patient with respective sense electrode combinations that each comprise at least one electrode; and a processor configured to select one of the sense electrode combinations based on a signal characteristic of each of the sensed bioelectrical signals, the signal characteristic indicating a location of the at least one electrode of the respective sense electrode combination relative to a target tissue site, access a physiological model that indicates one or more characteristics of tissue proximate the at least one electrode within the brain of the patient, and select, based on the signal characteristic of the bioelectrical signal sensed with the selected sense electrode combination and the physiological model, a stimulation electrode combination for delivering electrical stimulation to the brain of the patient. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A system comprising:
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a sensing module configured to sense a bioelectrical signal in a brain of a patient with a sense electrode combination that comprises at least one electrode; and a processor configured to access a physiological model that indicates one or more characteristics of tissue proximate the at least one electrode within the brain of the patient, select, based on a signal characteristic of the bioelectrical signal, a stimulation electrode combination for delivering electrical stimulation to the brain of the patient, the signal characteristic indicating a location of the at least one electrode relative to a target tissue site, and confirm the stimulation electrode combination based on the physiological model. - View Dependent Claims (28)
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29. A system comprising:
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a sensing module configured to sense a plurality of bioelectrical signals in a brain of a patient with respective sense electrode combinations that each comprise at least one electrode; and a processor configured to select one of the sense electrode combinations based on a signal characteristic of each of the sensed bioelectrical signals, the signal characteristic indicating a location of the at least one electrode of the respective sense electrode combination relative to a target tissue site, access a physiological model that indicates one or more characteristics of tissue proximate the at least one electrode within the brain of the patient, select, based on the physiological model, a stimulation electrode combination for delivering electrical stimulation to the brain of the patient, and confirm the selected stimulation electrode combination based on the signal characteristic of the bioelectrical signal sensed with the selected sense electrode combination. - View Dependent Claims (30)
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31. A system comprising:
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means for sensing a plurality of bioelectrical signals in a brain of a patient with respective sense electrode combinations that each comprise at least one electrode; means for selecting one of the sense electrode combinations based on a signal characteristic of each of the sensed bioelectrical signals, the signal characteristic indicating a location of the at least one electrode of the respective sense electrode combination relative to a target tissue site; and means for selecting, based on the signal characteristic of the bioelectrical signal sensed with the selected sense electrode combination and a physiological model that indicates one or more characteristics of tissue proximate the at least one electrode within the brain of the patient, a stimulation electrode combination for delivering electrical stimulation to the brain of the patient.
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32. A system comprising:
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means for sensing a plurality of bioelectrical signals in a brain of a patient with respective sense electrode combinations that each comprise at least one electrode; means for selecting one of the sense electrode combinations based on a signal characteristic of each of the sensed bioelectrical signals, the signal characteristic indicating a location of the at least one electrode of the respective sense electrode combination relative to a target tissue site; means for selecting, based on the signal characteristic of the bioelectrical signal sensed with the selected sense electrode combination, a stimulation electrode combination for delivering electrical stimulation to the brain of the patient, the signal characteristic indicating a location of the at least one electrode relative to a target tissue site; and means for confirming the stimulation electrode combination selection based on a physiological model that indicates one or more characteristics of tissue proximate the at least one electrode within the brain of the patient, wherein the physiological model comprises a therapy field model that indicates where stimulation will propagate from electrodes of the stimulation electrode combination, and wherein the means for confirming confirms the sitmulation electrode combination by at least determining whether the therapy field at least partially overlaps with a target anatomical structure of the brain of the patient or one or more anatomical structures of the brain associated with stimulation-induced side effects.
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33. A system comprising:
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means for sensing a plurality of bioelectrical signals in a brain of a patient with respective sense electrode combinations that each comprise at least one electrode; means for selecting one of the sense electrode combinations based on a signal characteristic of each of the sensed bioelectrical signals, the signal characteristic indicating a location of the at least one electrode of the respective sense electrode combination relative to a target tissue site; means for selecting, based on a physiological model that indicates one or more characteristics of tissue proximate the at least one electrode within the brain of the patient, a electrode combination for delivering electrical stimulation to the brain of the patient; and means for confirming the selected stimulation electrode combination based on the signal characteristic of the bioelectrical signal sensed with the selected sense electrode combination.
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34. A non-transitory computer-readable medium comprising instructions that cause a programmable processor to:
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receive, from a sensing module, a plurality of bioelectrical signals in a brain of a patient with respective sense electrode combinations that each comprise at least one electrode; select one of the sense electrode combinations based on a signal characteristic of each of the sensed bioelectrical signals, the signal characteristic indicating a location of the at least one electrode of the respective sense electrode combination relative to a target tissue site; access a physiological model that indicates one or more characteristics of tissue proximate the at least one electrode within the brain of the patient; and select, based on the signal characteristic of the bioelectrical signal sensed with the selected sense electrode combination and the physiological model, a stimulation electrode combination for delivering electrical stimulation to the brain of the patient.
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Specification