Expansion moulding of shape memory polymers

• US 9,815,240 B2
• Filed: 04/16/2008
• Issued: 11/14/2017
• Est. Priority Date: 04/18/2007
• Status: Expired due to Fees

• Current Assignee: Smith & Nephew Incorporated (Smith & Nephew PLC)
• Original Assignee: Smith & Nephew Incorporated (Smith & Nephew PLC)
• Inventors: Montes de Oca Balderas, Horacio, Brown, Malcolm
• Primary Examiner(s): Listvoyb, Gregory
• Application Number:
  US12/596,525
• Publication Number:
  US 20100136648A1
• Time in Patent Office: 3,499 Days
• Field of Search: 435180, 523105, 528272, 528310, 528300, 528354
• CPC Class Codes: A61L 2400/16 Materials with shape-memory or superelastic properties
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: B29C 61/006 the force created by the liberation of the internal stresses being used for compression moulding or for pressing preformed material
• CPC Class Codes: B29C 61/04 Thermal expansion
• CPC Class Codes: B29C 61/06 Making preforms having internal stresses, e.g. plastic memory
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

The present invention relates to shape memory materials and to a method for controlling shape change in shape memory materials. In particular, the invention relates to a method and a system for forming complex shapes from shape memory materials and to shape memory materials having complex shapes.

Claims

1. A pre-relaxed three-dimensional shape memory polymer material having a molded configuration made by the method comprising:

consolidating a material including an amorphous shape memory polymer material to form an isotropic cylinder in a first configuration;

orientating the amorphous shape memory polymer material in the isotropic cylinder having the first configuration thereby forming an orientated shape memory polymer material having a second configuration;

forming a mold about the orientated shape memory polymer material having the second configuration, such that the mold constrains the first portion of the oriented shape memory polymer material and the mold does not constrain a second portion of the oriented shape memory polymer material;

applying a source of energy to, and/or exposing to at least one plastizer the orientated shape memory polymer material having the second configuration while the first portion is within the mold, thereby at least partially relaxing the orientated shape memory polymer material into a third configuration in which only the first portion conforms to the configuration of the mold and in which the first portion retains more shape memory potential than the second portion;

ceasing the application of the source of energy to the shape memory polymer material when the shape memory polymer material is formed into the third configuration; and

removing the mold when the shape memory polymer material is formed into the third configuration and the application of the source of energy, and/or exposure to at least one plastizer has ceased, wherein the shape memory polymer material having the third configuration retains its configuration unless a source of energy is applied to, and/or at least one plastizer is exposed to the shape memory polymer material in the third configuration, the retention of the shape memory polymer material in the third configuration after ceasing the application of the source of energy to, and/or the exposure to at least one plasticer, and the removal of the mold being greater than the retention of a configuration formed of the same shape memory polymer material treated by the same method except for not being in a mold when at least partially relaxed, and wherein the first, second, and third configurations are different to each other, and molecular motion of the third pre-relaxed configuration is stimulated to trigger further relaxation, wherein the shape memory polymer comprises an amorphous polymer.

2. The material of claim 1, wherein the source of energy is selected from the group consisting of a magnetic field, an electric current, ultrasound, electromagnetic radiation, heat by convection, heat by conduction, radiation or any combination thereof.

3. The shape memory polymer material of claim 1, wherein the shape memory polymer is a copolymer.

4. The shape memory polymer material of claim 3, wherein the copolymer comprises a component selected from a group consisting of glycolide, lactide, ethylene glycol, or ε

-caprolactone.

5. The shape memory polymer material of claim 3, wherein the copolymer includes the amorphous polymer and at least one mobile and/or rigid polymer.

6. The shape memory polymer material of claim 3, wherein the copolymer includes a semi-crystalline polymer and at least one mobile polymer and/or one rigid polymer.

7. The shape memory polymer material of claim 5, wherein the mobile polymer includes polyethylene glycol, or ε

-caprolactone, or glycolide, or D,L lactide and the rigid polymer includes D-lactide or L-lactide.

8. The shape memory polymer material of claim 1, wherein the shape memory polymer includes particles such as mineral particles, or ceramic particles, or magnetic particles, or photosensitive particles, or any combination thereof.

9. The shape memory polymer material of claim 1, wherein the shape memory polymer includes one or more releasable bioactive agents.

10. The shape memory polymer material as claimed in claim 9, wherein the one or more releasable bioactive agents include bone morphogenic proteins, antibiotics, anti-inflammatories, angiogenic factors, osteogenic factors, monobutyrin, thrombin, modified proteins, platelet rich plasma/solution, platelet poor plasma/solution, bone marrow aspirate, cells sourced from plants or animals.

11. The shape memory polymer material of claim 1, wherein the shape memory polymer includes a cell growth promoter.

12. The shape memory polymer material of claim 1, the method further comprising applying a source of energy to, and/or exposing to at least one plastizer the third configuration after removal of the mold thereby fully relaxing the third configuration into a fourth configuration that is substantially the same configuration as the first, configuration.

13. The shape memory polymer material of claim 12, wherein the source of energy is selected from the group consisting of a magnetic field, an electric current, ultrasound, electromagnetic radiation, heat by convection, heat by conduction, radiation or any combination thereof.

14. The shape memory polymer material of claim 1, wherein the orientating of the unorientated shape memory polymer material having a first configuration thereby forming an orientated shape memory polymer material having a second configuration comprises orientating by zone drawing, hydrostatic extrusion, die drawing, rolling, roll drawing, compression moulding, or any combination thereof.