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Magnetically induced microspinning for super-detection and super-characterization of biomarkers and live cells

  • US 9,816,993 B2
  • Filed: 04/11/2012
  • Issued: 11/14/2017
  • Est. Priority Date: 04/11/2011
  • Status: Active Grant
First Claim
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1. A method of detecting a target, the method comprising:

  • (a) contacting the target which is immobilized on a non-magnetic substrate particle with a plurality of magnetic particles under conditions in which the magnetic particles are capable of associating or complexing with the target, wherein the diameter of the one or more magnetic particles is smaller relative to the diameter of the non-magnetic substrate particle;

    (b) applying a rotating magnetic field to the immobilized target which is associated or complexed with the magnetic particles; and

    (c) detecting rotation in the magnetic field arising from association or complex formation of one or more of the magnetic particles associated or complexed with the immobilized target, wherein detection of rotation and/or rate of rotation of the target indicates presence of the target.

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