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Methods for determining LDL cholesterol treatment

  • US 9,817,001 B2
  • Filed: 07/18/2013
  • Issued: 11/14/2017
  • Est. Priority Date: 05/27/2008
  • Status: Active Grant
First Claim
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1. A method for determining a cardiovascular disease (CVD) diagnosis and a personalized treatment for a patient, the method comprisingobtaining one or more samples from a patient;

  • measuring the one or more samples for levels of a plurality of HDL subfractions selected from the group consisting of α

    -1, α

    -2, α

    -3, α

    -4, and preβ

    -1 to create an HDL fingerprint, and when the HDL fingerprint indicates that the patient should be treated, then measuring the one or more samples for levels of;

    at least one marker of cholesterol absorption and at least one marker of cholesterol production, wherein the marker of cholesterol absorption is selected from the group consisting of beta-sitosterol and campesterol, and the marker of cholesterol production is lathosterol;

    comparing the levels of the marker of cholesterol absorption and the marker of cholesterol production to corresponding reference levels;

    classifying based on the comparison if the patient is a hypo-absorber, a hyper-absorber, an over-producer, a normal-producer of cholesterol or a combination thereof, wherein a level of lathosterol greater than the reference level indicates that the patient is an over-producer and a level of beta-sitosterol or campesterol higher than a corresponding reference level indicates that the patient is a hyper-absorber;

    determining a CVD diagnosis and a personalized therapy in response to the patient'"'"'s classification when the patient'"'"'s HDL fingerprint indicates that the patient should be treated.

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