Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo or a diffusion algorithm
First Claim
1. A system for determining biomarker concentrations in a tissue mass, the system comprising:
- an instrument for inserting into the tissue mass;
a fiber optic probe for interfacing the tissue mass upon being inserted into the instrument and measuring turbid spectral data of the tissue mass, wherein measuring the turbid spectral data includes conducting fluorescence spectral measurements and diffuse reflectance measurements of the tissue mass simultaneously, wherein the fiber optic probe is a forward firing fiber optic probe that includes a probe tip comprising a plurality of centrally grouped illumination fibers that are concentrically surrounded by a plurality of collection fiber rings, wherein each of the collection fiber rings consists of a plurality of ring-specific collection fibers or a plurality of ring-specific collection fibers and a plurality of dead fibers; and
a processing unit for converting the turbid spectral data to absorption, scattering, and intrinsic fluorescence spectral data via a Monte Carlo algorithm or a diffusion algorithm and quantifying biomarker concentrations in the tissue mass using the absorption, scattering, and intrinsic fluorescence spectral data, wherein the intrinsic fluorescence spectral data is corrected to account for the absorption and scattering data.
1 Assignment
0 Petitions
Accused Products
Abstract
Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo algorithm or a diffusion algorithm are provided. According to one method, an instrument is inserted into a tissue mass. A fiber optic probe is applied via the instrument into the tissue mass. Turbid spectral data of the tissue mass is measured using the fiber probe. The turbid spectral data is converted to absorption, scattering, and/or intrinsic fluorescence spectral data via a Monte Carlo algorithm or diffusion algorithm. Biomarker concentrations in the tissue mass are quantified using the absorption, scattering, and/or intrinsic fluorescence spectral data.
-
Citations
23 Claims
-
1. A system for determining biomarker concentrations in a tissue mass, the system comprising:
-
an instrument for inserting into the tissue mass; a fiber optic probe for interfacing the tissue mass upon being inserted into the instrument and measuring turbid spectral data of the tissue mass, wherein measuring the turbid spectral data includes conducting fluorescence spectral measurements and diffuse reflectance measurements of the tissue mass simultaneously, wherein the fiber optic probe is a forward firing fiber optic probe that includes a probe tip comprising a plurality of centrally grouped illumination fibers that are concentrically surrounded by a plurality of collection fiber rings, wherein each of the collection fiber rings consists of a plurality of ring-specific collection fibers or a plurality of ring-specific collection fibers and a plurality of dead fibers; and a processing unit for converting the turbid spectral data to absorption, scattering, and intrinsic fluorescence spectral data via a Monte Carlo algorithm or a diffusion algorithm and quantifying biomarker concentrations in the tissue mass using the absorption, scattering, and intrinsic fluorescence spectral data, wherein the intrinsic fluorescence spectral data is corrected to account for the absorption and scattering data. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
-
11. A method for determining biomarker concentrations in a tissue mass, the method comprising:
-
inserting an instrument into the tissue mass; applying a fiber optic probe upon being inserted into the instrument into the tissue mass, wherein the fiber optic probe is a forward firing fiber optic probe that includes a probe tip comprising a plurality of centrally grouped illumination fibers that are concentrically surrounded by a plurality of collection fiber rings, wherein each of the collection fiber rings consists of a plurality of ring-specific collection fibers or a plurality of ring-specific collection fibers and a plurality of dead fibers; measuring turbid spectral data of the tissue mass using the fiber optic probe, wherein measuring the turbid spectral data includes conducting fluorescence spectral measurements and diffuse reflectance measurements of the tissue mass simultaneously; converting the turbid spectral data to absorption, scattering, and intrinsic fluorescence spectral data via a Monte Carlo algorithm or a diffusion algorithm; and quantifying biomarker concentrations in the tissue mass using the at least one of absorption, scattering, and intrinsic fluorescence spectral data, wherein the intrinsic fluorescence spectral data is corrected to account for the absorption and scattering data. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
-
Specification