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Analyte detection system

  • US 9,820,690 B1
  • Filed: 07/16/2014
  • Issued: 11/21/2017
  • Est. Priority Date: 07/16/2014
  • Status: Active Grant
First Claim
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1. A system comprising:

  • a wearable device for detecting an analyte response signal and an unbound functionalized particle signal from tissue through an external surface of a living body, the wearable device comprising a mount adapted for mounting the wearable device on the external surface of a living body and a detector,wherein the tissue contains a biologically active agent in an inactive state and functionalized particles, wherein the functionalized particles can interact with one or more target analytes, wherein the biologically active agent can be converted from the inactive state to an active state, wherein the concentration or abundance of the one or more target analytes is correlated with a biological state of the living body that is affected by the biologically active agent when in the active state, wherein the analyte response signal is related to interaction of the one or more target analytes with the functionalized particles, and wherein the unbound functionalized particle signal is related to functional particles that are not interacting with the one or more target analytes;

    a directed energy source;

    a modulation source;

    a processor; and

    a computer readable medium storing instructions executable by the processor to perform operations comprising;

    controlling the directed energy source to apply directed energy into the tissue through the external surface, wherein the directed energy is sufficient to convert the biologically active agent from the inactive state to the active state;

    controlling the detector to detect an analyte response signal transmitted from tissue through the external surface;

    controlling the modulation source to modulate the analyte response signal and the unbound functionalized particle signal, such that the analyte response signal is affected differently than the unbound functionalized particle signal; and

    controlling the processor to determine the concentration or abundance of the one or more target analytes by differentiating the analyte response signal from the unbound functionalized particle signal, based, at least in part, on the modulation.

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