Deployment of polysaccharide markers for treating a site within a patent

• US 9,820,824 B2
• Filed: 09/29/2015
• Issued: 11/21/2017
• Est. Priority Date: 02/02/1999
• Status: Expired due to Term

• Current Assignee: Senorx Incorporated (Becton, Dickinson & Co)
• Original Assignee: Senorx Incorporated (Becton, Dickinson & Co)
• Inventors: Jones, Michael L., Lubock, Paul
• Primary Examiner(s): YOUNG, MICAH PAUL
• Application Number:
  US14/868,663
• Publication Number:
  US 20160015475A1
• Time in Patent Office: 784 Days
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61B 2017/00893 pharmaceutically effective
• CPC Class Codes: A61B 2017/00942 hydrophilic
• CPC Class Codes: A61B 2090/3908 Soft tissue, e.g. breast tissue
• CPC Class Codes: A61B 2090/3925 ultrasonic
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61B 2090/3987 Applicators for implanting markers
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers

Abstract

A method for treating a site within a patient from which tissue has been removed includes providing at least one press-formed marker body formed of polysaccharide and a suitable binder; and placing the at least one of the press-formed marker body within the site where tissue has been removed so as to provide hemostasis therein.

Claims

1. A system for delivery of at least one tissue marker to a site within a patient, comprising:

a marker delivery device having a delivery tube with an inner lumen and a discharge port, and a plunger slidably disposed within the inner lumen of the delivery tube, the plunger having a proximal end and a distal end, the proximal end having a head configured to allow an operator to move the plunger within the inner lumen; and

a press-formed marker body disposed in the inner lumen distal to the distal end of the plunger, wherein the press-formed marker body is formed of a mixture of 65% (by wt.) powder of corn starch or potato starch and 35% (by wt.) methylcellulose binder, and wherein moving the plunger in a distal direction pushes the press-formed marker body out of the discharge port and into the site within the patient.

2. The system of claim 1, further comprising a releasable plug positioned in the discharge port distal to the press-formed marker body.

3. The system of claim 1, wherein the mixture is placed in a pellet die and subjected to pressure, the press-formed marker body having a pair of opposed flat surfaces and a pair of opposed convex surfaces, the pair of opposed convex surfaces being orthogonal to the pair of opposed flat surfaces.

4. A system for delivery of tissue markers to a site within a patient, comprising:

a marker delivery device having a delivery tube with an inner lumen and a discharge port, and a plunger slidably disposed within the inner lumen of the delivery tube, the plunger having a proximal end and a distal end, the proximal end having a head configured to allow an operator to move the plunger within the inner lumen; and

a plurality of marker members positioned in the delivery tube distal to the plunger, each marker member of the plurality of marker members comprising a press-formed marker body formed of bioabsorbable polysaccharide and a binder, the bioabsorbable polysaccharide being in sufficient amounts to exhibit hemostatic properties, wherein at least one of the plurality of marker members is formed of a mixture of 65% (by wt.) powder of corn starch or potato starch and 35% (by wt.) methylcellulose binder.

5. The system of claim 4, wherein each of the plurality of marker elements is urged out the discharge port by a distal movement of the plunger.

6. The system of claim 4, wherein another at least one marker element of the plurality of marker elements is about 10 to about 90% (by wt.) bioabsorbable polysaccharide.

7. The system of claim 4, wherein another at least one marker element of the plurality of marker elements is a bioabsorbable polysaccharide selected from the group consisting of starch, glycogen, cellulose, chitin, chitosan, dextran, pectins, glucans, agar, alginate and carrageen.

8. The system of claim 4, wherein the mixture is placed in a pellet die and subjected to pressure to form a unitary marker pellet, the unitary marker pellet having a pair of opposed flat surfaces and a pair of opposed convex surfaces, the pair of opposed convex surfaces being orthogonal to the pair of opposed flat surfaces.