Beta and alpha emission tomography for three-dimensional autoradiography

• US 9,823,364 B2
• Filed: 02/03/2015
• Issued: 11/21/2017
• Est. Priority Date: 02/03/2014
• Status: Active Grant

• Current Assignee: InviCRO LLC (Konica Minolta Inc.), Arizona Board of Regents (University of Arizona)
• Original Assignee: InviCRO LLC (Konica Minolta Inc.), Arizona Board of Regents (University of Arizona)
• Inventors: Barrett, Harrison H., Miller, Brian, Ding, Yijun, Chen, Liying, Hoppin, John William, Caucci, Luca
• Primary Examiner(s): Gaworecki, Mark R
• Application Number:
  US15/116,173
• Publication Number:
  US 20170010369A1
• Time in Patent Office: 1,022 Days
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 6/5205 involving processing of raw data to produce diagnostic data
• CPC Class Codes: G01T 1/161 Applications in the field of nuclear medicine, e.g. in vivo counting apparatus for radiation diagnosis A61B6/00
• CPC Class Codes: G01T 1/2942 using autoradiographic methods
• CPC Class Codes: G01T 1/2985 In depth localisation, e.g. using positron emitters; Tomographic imaging (longitudinal and transverse section imaging; apparatus for radiation diagnosis sequentially in different planes, steroscopic radiation diagnosis); using external radiation sources A61B6/02
• CPC Class Codes: G01T 5/08 Scintillation chambers discharge tubes H01J40/00, H01J47/00; semiconductor devices H01L

Abstract

The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.

Claims

1. A device for imaging a source of particles comprising:

a particle track detector for recording images of detectable signals generated along particle tracks in an active material, wherein said detectable signals are generated by an interaction of a particle from said source with said active material, wherein said particle comprises a beta particle, alpha particle, a positron or a conversion electron; and

a processor positioned in data communication with said particle track detector, wherein said processor is configured for;

analyzing a plurality of images of detectable signals generated along particle tracks of a plurality of particles in an active material to determine attributes of said plurality particle tracks; and

reconstructing a 3D image of said source of particles using attributes corresponding to all of said plurality of particles,

wherein said attributes comprise one or more of a position of a start of a particle track, a direction of travel of a particle at a start of a particle track, and a total energy deposited by a particle along particle track.

2. The device of claim 1, wherein said active material comprises a scintillator, a microchannel plate, a depletion region of a deep-depletion CCD device or deep-depletion CMOS.

3. The device of claim 1, wherein said position sensitive detector comprises a two-dimensional optical detector, a two-dimensional electronic detector, a CCD detector, a deep-depletion CCD detector, a CMOS detector or an active pixel sensor.

4. The device of claim 1 further comprising a camera for obtaining a white-light image of a surface of a tissue.

5. The device of claim 1 further comprising a tomographic imaging system.

6. A device for imaging a source of particles comprising:

a particle track detector for recording images of detectable signals generated along particle tracks in an active material, wherein said detectable signals are generated by an interaction of a particle from said source with said active material, wherein said particle comprises a beta particle, alpha particle, a positron or a conversion electron;

a camera for obtaining a white-light image of a surface of a tissue; and

a processor positioned in data communication with said particle track detector, wherein said processor is configured for;

analyzing a plurality of images of detectable signals generated along particle tracks of a plurality of particles in an active material to determine attributes of said plurality particle tracks; and

reconstructing a 3D image of said source of particles using attributes corresponding to all of said plurality of particles.

7. The device of claim 6, wherein said active material comprises a scintillator, a microchannel plate, a depletion region of a deep-depletion CCD device or deep-depletion CMOS.

8. The device of claim 6, wherein said position sensitive detector comprises a two-dimensional optical detector, a two-dimensional electronic detector, a CCD detector, a deep-depletion CCD detector, a CMOS detector or an active pixel sensor.

9. The device of claim 6 further comprising a tomographic imaging system.