Neuroplasticity games for addiction

• US 9,824,602 B2
• Filed: 02/08/2016
• Issued: 11/21/2017
• Est. Priority Date: 03/07/2013
• Status: Active Grant

• Current Assignee: Posit Science Corp.
• Original Assignee: Posit Science Corp.
• Inventors: Merzenich, Michael M., Luk, Chung-Hay, Nahum, Mor, Ramanathan, Jyoti Mishra, Van Vleet, Thomas Matthew
• Primary Examiner(s): Rowland, Steve
• Application Number:
  US15/017,760
• Publication Number:
  US 20160155353A1
• Time in Patent Office: 652 Days
• CPC Class Codes: A63F 13/47 involving branching, e.g. choosing one of several possible scenarios at a given point in time
• CPC Class Codes: A63F 13/537 using indicators, e.g. showing the condition of a game character on screen
• CPC Class Codes: A63F 13/67 adaptively or by learning from player actions, e.g. skill level adjustment or by storing successful combat sequences for re-use
• CPC Class Codes: A63F 13/80 Special adaptations for executing a specific game genre or game mode
• CPC Class Codes: G09B 19/00 Teaching not covered by other main groups of this subclass teaching or practice apparatus for gun-aiming or gun-laying F41G3/26
• CPC Class Codes: G09B 5/00 Electrically-operated educational appliances working with questions and answers G09B7/00; simulators G09B9/00; advertising or displaying in general G09F
• CPC Class Codes: G09B 5/02 with visual presentation of the material to be studied, e.g. using film strip
• CPC Class Codes: G09B 5/06 with both visual and audible presentation of the material to be studied
• CPC Class Codes: G09B 5/065 Combinations of audio and video presentations, e.g. videotapes, videodiscs, television systems
• CPC Class Codes: G16H 20/70 relating to mental therapies, e.g. psychological therapy or autogenous training
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

A training program is configured to systematically drive neurological changes to treat an addiction, wherein a plurality of addiction-related stimuli stimulate craving for the object of the addiction. The training program comprises at least one computerized reverse conditioning game configured to present a plurality of target and distractor stimuli, wherein the distractor stimuli are addiction-related stimuli, and prompts a game participant to respond to the target stimuli and ignore the distractor stimuli.

Claims

1. A computerized reverse conditioning game program for the treatment of a substance addiction, wherein a plurality of addiction-related stimuli that represent one or more substances to which the addiction is directed or settings in which one or more substances to which the addiction is directed are enjoyed are presented to stimulate craving for the substance to which the addiction is directed, the game program comprising:

a plurality of target stimuli that are not addiction-related;

a plurality of addiction-related distractor stimuli; and

a game manager configured to administer a delay discounting game and exercise by challenging a game participant to selectively respond, through manipulation of a game piece, to the target stimuli, while also challenging the game participant to selectively withhold providing the same response to the distractor stimuli; and

the game manager being further configured to receive the game participant'"'"'s input through the game piece and indicate whether the game participant'"'"'s inputs are appropriate;

wherein the indications encourage the participant to withhold providing a response to the distractor stimuli, thereby reducing the participant'"'"'s craving for the substances to which the participant'"'"'s craving is directed;

the game manager being further configured to assess the game participant'"'"'s level of craving and willingness to delay gratification.

2. The computerized reverse conditioning game program of claim 1, wherein the game manager is configured to:

display a set of spatially distributed images for a brief interval of time, wherein one image of the set has a positive valence, and another image of the set illustrates a substance to which the addiction is directed or a setting in which the substance of the addiction is enjoyed;

stop displaying the set of images; and

subsequently display an image in a position where the image with a positive valence was located.

3. The computerized reverse conditioning game program of claim 1, wherein the game manager is configured to:

disclose a target category to the game participant, wherein the target stimuli to be presented belong to the target category;

prompt the game participant to remember at least one freeze stimulus, wherein the at least one freeze stimulus belongs to the target category;

prompt the game participant to indicate, through the game piece, whether the stimuli, when presented, belong to the target category; and

present a plurality of stimuli over a plurality of trials, wherein some of the stimuli are distractor stimuli that do not belong to the target category, some of the stimuli are target stimuli belonging to the target category, and at least one stimulus is the at least one freeze stimulus;

wherein the game manager challenges the game participant to selectively respond to stimuli, through the game piece, that fall within the target category while withholding the same response, through the game piece, to either the at least one freeze stimulus or to any other stimuli that do not belong to the target category.

4. The computerized reverse conditioning game program of claim 1, wherein the game manager challenges the game participant to match a challenge stimulus to a target stimulus in a context that includes a plurality of stimuli selected to stimulate craving for the substance to which the addiction is directed.

5. The computerized reverse conditioning game program of claim 1, wherein the game is a time tracking game and the game manager challenges the game participant to keep track of time.

6. The computerized reverse conditioning game program of claim 1, wherein the game manager challenges the game participant to indicate whether a target stimulus was present in a plurality of stimuli, one or more of which was selected to stimulate craving for the object of the addiction, wherein the target stimulus is not related to the substance to which the addiction is directed.

7. The computerized reverse conditioning game program of claim 1, wherein the game manager challenges the game participant to identify colors of words, some of which have semantic content selected to stimulate craving for the substance to which the addiction is directed, while ignoring the semantic content of the words.

8. The computerized reverse conditioning game program of claim 7, wherein the substance addiction is alcoholism, and the distractor stimuli comprise images of alcoholic beverages and social scenes of people enjoying alcoholic beverages.

9. A method of treating a substance addiction, wherein a plurality of addiction-related stimuli that represent one or more substances to which the addiction is directed or settings in which one or more substances to which the addiction is directed are enjoyed are presented to stimulate craving for the substance to which the addiction is directed, the method comprising:

administering a game to a game participant;

presenting a plurality of target and distractor stimuli, wherein the target stimuli are not addiction-related and the distractor stimuli are addiction-related;

challenging the game participant to selectively respond, through manipulation of a game piece, to the target stimuli, while also challenging the game participant to selectively withhold providing the same response to the distractor stimuli; and

receiving the game participant'"'"'s input through the game piece and indicating whether the game participant'"'"'s inputs are appropriate;

wherein the indications encourage the participant to withhold providing a response to the distractor stimuli, thereby reducing the participant'"'"'s craving for the substances to which the participant'"'"'s craving is directed; and

assessing the game participant'"'"'s level of craving and willingness to delay gratification.

10. The method of claim 9, further comprising:

displaying a set of spatially distributed images for a brief interval of time, wherein one image of the set has a positive valence, and another image of the set illustrates a substance to which the addiction is directed or a setting in which the substance of the addiction is enjoyed;

stop displaying the set of images; and

subsequently displaying an image in a position where the image with a positive valence was located.

11. The method of claim 9, further comprising:

disclosing a target category to the game participant, wherein the target stimuli to be presented belong to the target category;

prompting the game participant to remember at least one freeze stimulus, wherein the at least one freeze stimulus belongs to the target category;

prompting the game participant to indicate, through the game piece, whether the stimuli, when presented, belong to the target category; and

presenting a plurality of stimuli over a plurality of trials, wherein some of the stimuli are distractor stimuli that do not belong to the target category, some of the stimuli are target stimuli belonging to the target category, and at least one stimulus is the at least one freeze stimulus;

wherein the game manager challenges the game participant to selectively respond to stimuli, through the game piece, that fall within the target category while withholding the same response, through the game piece, to either the at least one freeze stimulus or to any other stimuli that do not belong to the target category.

12. The method of claim 9, further comprising challenging the game participant to match a challenge stimulus to a target stimulus in a context that includes a plurality of stimuli selected to stimulate craving for the substance to which the addiction is directed.

15. The method of claim 9, wherein the substance addiction is alcoholism, and the distractor stimuli comprise images of alcoholic beverages and social scenes of people enjoying alcoholic beverages.

16. The method of claim 9, further comprising challenging the game participant to identify colors of words, some of which have semantic content selected to stimulate craving for the substance to which the addiction is directed, while ignoring the semantic content of the words.

13. A method of treating a substance addiction, wherein a plurality of addiction-related stimuli that represent one or more substances to which the addiction is directed or settings in which one or more substances to which the addiction is directed are enjoyed are presented to stimulate craving for the substance to which the addiction is directed, the method comprising:

administering a time tracking game to a game participant;

presenting a plurality of target and distractor stimuli, wherein the target stimuli are not addiction-related and the distractor stimuli are addiction-related;

challenging the game participant to keep track of time and to selectively respond, through manipulation of a game piece, to the target stimuli, while also challenging the game participant to selectively withhold providing the same response to the distractor stimuli; and

receiving the game participant'"'"'s input through the game piece and indicating whether the game participant'"'"'s inputs are appropriate;

wherein the indications encourage the participant to withhold providing a response to the distractor stimuli, thereby reducing the participant'"'"'s craving for the substances to which the participant'"'"'s craving is directed.

14. A method of treating a substance addiction, wherein a plurality of addiction-related stimuli that represent one or more substances to which the addiction is directed or settings in which one or more substances to which the addiction is directed are enjoyed are presented to stimulate craving for the substance to which the addiction is directed, the method comprising:

administering a game to a game participant;

presenting a plurality of target and distractor stimuli, wherein the target stimuli are not addiction-related and the distractor stimuli are addiction-related;

challenging the game participant to selectively respond, through manipulation of a game piece, to the target stimuli, while also challenging the game participant to selectively withhold providing the same response to the distractor stimuli, and to indicate whether a target stimulus was present in a plurality of stimuli, one or more of which was selected to stimulate craving for the object of the addiction, wherein the target stimulus is not related to the substance to which the addiction is directed;

receiving the game participant'"'"'s input through the game piece and indicating whether the game participant'"'"'s inputs are appropriate;

wherein the indications encourage the participant to withhold providing a response to the distractor stimuli, thereby reducing the participant'"'"'s craving for the substances to which the participant'"'"'s craving is directed.