Systems and methods which remove material from blood vessel walls

• US 9,826,996 B2
• Filed: 01/31/2012
• Issued: 11/28/2017
• Est. Priority Date: 01/31/2011
• Status: Active Grant

• Current Assignee: Advanced Magnet Lab Incorporated
• Original Assignee: Advanced Magnet Lab Incorporated
• Inventors: Meinke, Rainer, Ishmael, Sasha
• Primary Examiner(s): Carey, Michael
• Assistant Examiner(s): Patel, Natasha
• Application Number:
  US13/982,784
• Publication Number:
  US 20130310626A1
• Time in Patent Office: 2,128 Days
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 17/22012 in direct contact with, or very close to, the obstruction or concrement for removing obstructions in blood vessels by laser A61B18/245
• CPC Class Codes: A61B 2017/22002 preventing restenosis
• CPC Class Codes: A61B 2017/22081 Treatment of vulnerable plaque
• CPC Class Codes: A61B 2018/00386 Coronary vessels
• CPC Class Codes: A61B 2018/00404 Blood vessels other than those in or around the heart
• CPC Class Codes: A61B 34/73 Manipulators for magnetic surgery
• CPC Class Codes: A61N 1/32 alternating or intermittent currents applying electric fields by inductive or capacitive coupling A61N1/40; microwave apparatus A61N5/02
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals
• CPC Class Codes: A61N 2/004 specially adapted for a specific therapy
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence

Abstract

Systems and methods for removing plaque from blood vessels by applying constant or time varying magnetic or electrical fields. In one embodiment a system includes winding configurations positioned about a central axis along which a body region may be placed. Each winding configuration generates a magnetic field in a direction which passes through the body region. A first winding configuration generates a first magnetic field component perpendicular to a second magnetic field component generated by a second winding configuration. In a related method for removing a deposit of plaque from a position along a wall of a blood vessel a magnetic field is applied which has a net direction predominantly orthogonal to the direction of the flow of blood through the vessel.

Claims

1. A method for removing molecules in a layer of plaque from a position along a wall of a blood vessel through which blood flows in a direction, comprising:

applying an electric field to at least a portion of a person'"'"'s body, wherein the electric field is produced by at least one external component to the body, the electric field having a net direction predominantly orthogonal to the direction of the flow of blood through the vessel, the field produced by the at least one external component being 0.01 Tesla to 5 Tesla of sufficient strength, without the need for an energy focusing device placed within the person'"'"'s body, to dissociate a first molecule in the layer of plaque from another molecule in the layer, or from a molecule which forms the blood vessel wall, by severing a bond which otherwise stabilizes the position of the first molecule within the layer of plaque.

2. The method of claim 1 wherein the electric field is applied by generating a voltage between two plates.

3. The method of claim 1 wherein the electric field is a pulsed field.

4. A method for removing molecules in a layer of plaque positioned along a wall of a blood vessel through which blood flows in a direction, comprising:

applying a magnetic field to at least a portion of a person'"'"'s body, wherein the magnetic field is produced by at least one external component to the body, the magnetic field including a component having a direction predominantly orthogonal to the direction of the flow of blood through the vessel, the field produced by the at least one external component being 0.01 Tesla to 5 Tesla of sufficient strength, without the need for an energy focusing device placed within the person'"'"'s body, to cause charge separation of conductive carriers in the blood resulting in an electric field;

wherein said electric field alters association of non-polar molecules or slightly polar molecules which have accumulated along the wall of the blood vessel by providing energy greater than the energy which binds the molecules together thereby contributing to dissociation of the molecules and allowing the molecules to travel with the blood in the vessel.

5. The method of claim 4 wherein the applied magnetic field is a pulsed field.

6. The method of claim 5 wherein the electric field is applied in the absence of magnetic field.