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Methods and apparatus for intravascularly-induced neuromodulation

  • US 9,827,040 B2
  • Filed: 07/18/2014
  • Issued: 11/28/2017
  • Est. Priority Date: 04/08/2002
  • Status: Expired due to Term
First Claim
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1. An apparatus for intravascularly-induced neuromodulation of a human patient, the apparatus comprising:

  • a pulsed electric field generator adapted to be placed external to the patient;

    an intravascular catheter configured for transluminal delivery to a renal blood vessel of the patient, the catheter comprising a shaft, a balloon carrying monitoring electrodes, and a pair of bipolar electrodes positioned on the shaft on opposite ends of and external to the balloon,wherein the bipolar electrodes are electrically coupled to the pulsed electric field generator,wherein the monitoring electrodes are electrically coupled to a monitoring component of the pulsed electric field generator, and wherein the monitoring component is configured to monitor neural signaling across renal neural fibers, andwherein the catheter is further configured to improve renal function in the patient by directing a pulsed electric field from the pulsed electric field generator across the bipolar electrodes to block neural signaling across target renal neural fibers along the renal blood vessel.

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