Multispot monitoring for use in optical coherence tomography
First Claim
1. A method for performing optical coherence tomography measurements to determine an analyte level in tissue, comprising:
- aligning an optical coherence tomography system to a tissue region of a subject through an optical coupler, wherein the tissue region includes at least a first tissue site and a second tissue site, and wherein the first and second tissue sites comprise spatially distinct two-dimensional regions of a skin surface of the subject;
scanning, by a scanner of the optical coherence tomography system, a beam over the first tissue site using the optical coupler to collect a first set of optical coherence tomography measurements;
scanning, by the scanner of the optical coherence tomography system, the beam over the second tissue site using the optical coupler to collect a second set of optical coherence tomography measurements;
determining, by a processor of the optical coherence tomography system, based on the first set of optical coherence tomography measurements, that the first tissue site is an analyte correlating region, wherein an analyte correlating region comprises a tissue site that is valid for measuring an analyte level;
determining, by the processor of the optical coherence tomography system, based on the second set of optical coherence tomography measurements, that the second tissue site is not an analyte correlating region and not valid for measuring an analyte level; and
monitoring, by the processor of the optical coherence tomography system, the analyte level by at least;
causing the scanner to monitor the first tissue site and processing optical coherence tomography measurements associated with the first tissue site to measure the analyte level; and
causing the scanner to not monitor and not processing optical coherence tomography measurements associated with the second tissue site.
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Accused Products
Abstract
Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis.
927 Citations
25 Claims
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1. A method for performing optical coherence tomography measurements to determine an analyte level in tissue, comprising:
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aligning an optical coherence tomography system to a tissue region of a subject through an optical coupler, wherein the tissue region includes at least a first tissue site and a second tissue site, and wherein the first and second tissue sites comprise spatially distinct two-dimensional regions of a skin surface of the subject; scanning, by a scanner of the optical coherence tomography system, a beam over the first tissue site using the optical coupler to collect a first set of optical coherence tomography measurements; scanning, by the scanner of the optical coherence tomography system, the beam over the second tissue site using the optical coupler to collect a second set of optical coherence tomography measurements; determining, by a processor of the optical coherence tomography system, based on the first set of optical coherence tomography measurements, that the first tissue site is an analyte correlating region, wherein an analyte correlating region comprises a tissue site that is valid for measuring an analyte level; determining, by the processor of the optical coherence tomography system, based on the second set of optical coherence tomography measurements, that the second tissue site is not an analyte correlating region and not valid for measuring an analyte level; and monitoring, by the processor of the optical coherence tomography system, the analyte level by at least; causing the scanner to monitor the first tissue site and processing optical coherence tomography measurements associated with the first tissue site to measure the analyte level; and causing the scanner to not monitor and not processing optical coherence tomography measurements associated with the second tissue site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method comprising:
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directing, by a processor and/or controller of an optical coherency tomography system, a beam of radiation suitable for optical coherence tomography measurements from a beam scanner to a plurality of different tissue sites on a two-dimensional region of a skin surface of a subject to scan the plurality of different tissue sites, wherein the each of the plurality of different tissue sites is spatially distinct from one another on the two-dimensional region of the skin surface; determining, by the processor and/or controller of the optical coherency tomography system, from the plurality of different tissue sites, a first subset of tissue sites that each include an analyte correlating region, wherein an analyte correlating region comprises a tissue site that is valid for measuring an analyte level; determining, by the processor and/or controller of the optical coherency tomography system, from the plurality of different tissue sites, a second subset of tissue sites that each do not include an analyte correlating region; and monitoring, by the processor and/or controller of the optical coherency tomography system, the analyte level by at least; causing the beam scanner to monitor each of the first subset of tissue sites determined to include analyte correlating regions; and causing the beam scanner to not monitor the second subset of tissue sites. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification