Methods of detecting parameters of a lumen

• US 9,833,190 B2
• Filed: 01/21/2016
• Issued: 12/05/2017
• Est. Priority Date: 10/07/2008
• Status: Active Grant

• Current Assignee: Medidata Solutions Incorporated (Dassault Systemes SA)
• Original Assignee: MC10, Inc.
• Inventors: Ghaffari, Roozbeh, Callsen, Gilman, Arora, William J., Schlatka, Benjamin
• Primary Examiner(s): Price, Nathan R
• Assistant Examiner(s): LEE, WENG WAH
• Application Number:
  US15/003,644
• Publication Number:
  US 20160135740A1
• Time in Patent Office: 684 Days
• CPC Class Codes: A61B 1/00082 Balloons
• CPC Class Codes: A61B 1/3137 for examination of the interior of blood vessels
• CPC Class Codes: A61B 5/0036 including treatment, e.g., using an implantable medical device, ablating, ventilating
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/015 By temperature mapping of body part
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/02014 Determining aneurysm
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/6853 with a balloon
• CPC Class Codes: A61B 5/7271 Specific aspects of physiological measurement analysis A61B5/316, A61B5/349 and A61B5/374 take precedence
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61M 2025/1086 having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

A system, device and method are presented for utilizing stretchable active integrated circuits with inflatable bodies. The invention allows for such operative features to come into direct contact with body structures, such as the inner wall of a lumen. Such direct contact increases accuracy of measurement and delivery of therapy.

Claims

1. A method to detect parameters inside of a lumen comprising:

inserting an inflatable body into said lumen, said inflatable body having a stretchable surface and a stretchable electronic circuit affixed thereto, said stretchable surface having soft or elastic properties enabling the stretchable surface to be made longer or wider without tearing or breaking, said stretchable electronic circuit being embedded in or affixed to the stretchable surface, the stretchable electronic circuit comprising;

a plurality of discrete operative devices arranged as device islands on the stretchable surface, the plurality of discrete operative devices including at least one discrete operative device and at least one other discrete operative device; and

a plurality of stretchable interconnects embedded in or affixed to the stretchable surface to electrically interconnect at least some of the plurality of discrete operative devices, wherein at least one stretchable interconnect of the plurality of stretchable interconnects is directly attached to the at least one discrete operative device and to the at least one other discrete operative device to directly electrically interconnect the at least one discrete operative device to the at least one other discrete operative device;

inflating the inserted inflatable body to contact the at least one discrete operative device, the at least one other discrete operative device, or a combination thereof to said lumen; and

measuring a parameter of said lumen in response to the contact.

2. The method of claim 1, further comprising providing a therapy to the lumen based on said measured parameter.

3. The method of claim 1, further comprising generating a graphical output based on said measured parameter.

4. The method of claim 3, wherein the graphical output is a map of the lumen.

5. The method of claim 1, wherein the at least one discrete operative device and the at least one other discrete operative device detect data related to the lumen.

6. The method of claim 5, wherein said data is related to electrical conductivity of plaque inside of the lumen.

7. The method of claim 5, wherein said data is related to pH.

8. The method of claim 5, wherein said data is related to enzymatic activity.

9. The method of claim 5, wherein said data is related to chemical activity.

10. The method of claim 5, further comprising continuously generating said data from the at least one discrete operative device and the at least one other discrete operative device.

11. The method of claim 10, further comprising continuously recording said data generated by the at least one discrete operative device and the at least one other discrete operative device.

12. The method of claim 1, wherein each stretchable interconnect of the plurality of stretchable interconnects is directly attached to respective discrete operative devices of the plurality of discrete operative devices to directly electrically interconnect the plurality of discrete operative devices.

13. The method of claim 2, wherein at least one discrete operative device of the plurality of discrete operative devices comprises a drug delivery polymer comprising a drug.

14. The method of claim 13, further comprising activating the at least one discrete operative device comprising the drug delivery polymer to deliver the drug and provide the therapy to the lumen.

15. The method of claim 14, wherein the drug is an anti-inflammatory drug.

16. The method of claim 1, wherein the measured parameter is temperature data.

17. The method of claim 16, further comprising:

receiving, at a processor, the temperature data; and

generating, by the processor, a spatial temperature map of the lumen based on the temperature data.

18. The method of claim 17, further comprising:

causing, by the processor, an outputting of the temperature map to a display associated with the inflatable body.

19. The method of claim 1, wherein the plurality of discrete operative devices includes an amplifier, a semiconductor structure, a transducer, a photodetector, an ultrasound emitter, a light emitting device, a capacitance sensor, a piezo-electric sensor, a temperature sensor, or a combination thereof.

20. The method of claim 1, wherein the inflatable body is expandable.

21. The method of claim 1, wherein the plurality of discrete operative devices include a plurality of temperature sensors, the method further comprising:

taking a plurality of temperature measurements via the plurality of temperature sensors at multiple contact points on the lumen; and

processing the plurality of temperature measurements to produce a spatial temperature map of the lumen, the spatial temperature map indicating plaque on the lumen.

22. The method of claim 21, further comprising:

determining a plaque type, a location of the plaque, or a combination thereof based on the spatial temperature map.

23. The method of claim 22, further comprising:

activating one or more drug-delivery devices of the plurality of discrete operative devices to release one or more chemical agents in response to the determined plaque type, the location of the plaque, or a combination thereof.

24. The method of claim 23, wherein a subset of the one or more drug-delivery devices are activated, the subset corresponding to the location of the plaque.

25. The method of claim 23, wherein the one or more chemical agents include one or more anti-inflammatory drugs, one or more drug delivery polymers, or a combination thereof.

26. The method of claim 25, wherein the plurality of discrete operative devices include a plurality of light emitting devices, the method further comprising:

emitting light from the plurality of light emitting devices to activate the one or more released drug delivery polymers.

27. The method of claim 1, further comprising:

generating a graphical tactile image map of surface contours of the lumen based on the measured parameter to detect plaque within the lumen.

28. The method of claim 27, wherein the at least one discrete operative device and the at least one other discrete operative device are a pressure sensors, and the measured parameter is a pressure measurement.

29. The method of claim 6, further comprising determining whether the plaque inside the lumen is vulnerable based on the data.