Medical devices for renal nerve ablation

• US 9,833,283 B2
• Filed: 06/25/2014
• Issued: 12/05/2017
• Est. Priority Date: 07/01/2013
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Hanson, Cass A., Cao, Hong, Chen, John Jianhua, Sutermeister, Derek C., Quillin, Daniel T., Pederson, Jr., Gary J.
• Primary Examiner(s): Peffley, Michael
• Application Number:
  US14/314,848
• Publication Number:
  US 20150005764A1
• Time in Patent Office: 1,259 Days
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2018/0022 Balloons
• CPC Class Codes: A61B 2018/00404 Blood vessels other than those in or around the heart
• CPC Class Codes: A61B 2018/00434 Neural system
• CPC Class Codes: A61B 2018/00511 Kidney
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00797 measured by multiple temperature sensors
• CPC Class Codes: A61B 2018/124 switching the output to different electrodes, e.g. sequentially
• CPC Class Codes: A61B 2018/1467 using more than two electrodes on a single probe
• CPC Class Codes: A61B 2018/162 located on the probe body
• CPC Class Codes: A61B 2018/165 Multiple indifferent electrodes

Abstract

Medical devices and methods for making and using the same are disclosed. An example medical device may include a medical device for renal nerve ablation. The medical device may include an elongate shaft having a distal region. An expandable member may be coupled to the distal region. A plurality of electrodes may be coupled to the expandable member and a single conductive member may be coupled to each electrode. Where one of the plurality of electrodes is active, the remaining electrodes may be inactive and act as ground or return electrodes. The electrode of the plurality of electrodes that is active may change over time.

Claims

1. A medical device for performing ablation procedures, comprising:

an elongate shaft having a distal region;

an expandable member in the form of an expandable balloon having a cylindrical central portion coupled to the distal region;

a plurality of electrodes comprising at least four electrodes coupled to the expandable member;

a conductive member connected to each of the electrodes, where each of the connected conductive members is capable of supplying power to the electrode to which the conductive member is connected; and

a controller connected to each of the conductive members;

wherein the controller is configured to activate each of the plurality of electrodes by supplying power to each of the plurality of electrodes; and

wherein the controller is configured such that when the controller activates one of the plurality of electrodes by supplying power to one of the plurality of electrodes, the controller automatically maintains all of the remaining unpowered electrodes as inactive so as to act as ground electrodes.

2. The medical device of claim 1, further comprising:

one or more temperature sensors coupled to the expandable member; and

a single conductive member connected to each of the one or more temperature sensors.

3. The medical device of claim 1, wherein the conductive member is a conductive trace.

4. The medical device of claim 1, wherein the one of the plurality of electrodes that is activated changes over time.

5. The medical device of claim 1, wherein each of the plurality of electrodes is activated for an equal amount of time.

6. The medical device of claim 1, further comprising:

a coating of insulating material covering each of the conductive members.

7. The medical device of claim 6, wherein the coating comprises a thermoplastic polyurethane (TPU).

8. The medical device of claim 6, wherein the coating comprises a plurality of layers of material.

9. The medical device of claim 1, wherein the balloon is configured to be advanced through a blood vessel to a position within a renal artery and subsequently expanded in the renal artery.

10. The medical device of claim 1, wherein the plurality of electrodes comprises more than four electrodes.

15. A method for ablating renal nerves, the method comprising:

advancing the medical device of claim 1 through a blood vessel to a position within a renal artery;

expanding the expandable member;

activating one of the plurality of electrodes; and

automatically maintaining all of the remaining electrodes of the plurality of electrodes as inactive so as to function as ground electrodes,

thereby performing renal nerve ablation.

16. The method of claim 15, further comprising:

deactivating the one activated electrode of the plurality of electrodes; and

activating another of the plurality of electrodes.

17. The method of claim 15,

wherein the four electrodes correspond to a first electrode, a second electrode, a third electrode, and a fourth electrode;

wherein the first electrode is the one of the plurality of electrodes activated; and

the second electrode, the third electrode, and the fourth electrode are inactive electrodes and act as ground electrodes; and

wherein the method further comprises;

deactivating the first electrode after a first period of time;

activating the second electrode;

automatically maintaining the first electrode, the third electrode, and the fourth electrode as inactive to act as ground electrodes;

deactivating the second electrode after a second period of time;

activating the third electrode;

automatically maintaining the first electrode, second electrode, and the fourth electrode as inactive to act as ground electrodes; and

deactivating the third electrode after a third period of time;

activating the fourth electrode; and

automatically maintaining the first electrode, second electrode, and the third electrode as inactive to act as ground electrodes.

18. The method of claim 17, wherein the first period of time is substantially equal to one or more of the second period of time and the third period of time.

19. The method of claim 17, wherein each period of time is different than each other period of time.

11. A medical device for renal nerve ablation, comprising:

an elongate shaft having a distal region;

an expandable balloon having a cylindrical central portion coupled to the distal region, wherein the balloon is configured to be advanced through a blood vessel to a position within a renal artery and expanded in the renal artery;

a plurality of electrodes comprising four electrodes coupled to the balloon; and

a plurality of conductive traces coupled to the elongate shaft, where a single conductive trace of the plurality of conductive traces is connected to each of the electrodes such that each of the connected single conductive traces is capable of supplying power to the electrode to which the single conductive trace is connected; and

a controller connected to each of the conductive traces, wherein the controller is configured to activate each of the plurality of electrodes by supplying power to each of the plurality of electrodes;

wherein the controller is configured such that when the controller activates one of the plurality of electrodes by supplying power to one of the plurality of electrodes, the controller automatically maintains all of the remaining plurality of electrodes as inactive so as to act as a ground electrode.

12. The medical device of claim 11, further comprising:

a flex circuit disposed along the balloon; and

wherein at least one of the plurality of electrodes is disposed along the flex circuit.

13. The medical device of claim 11, further comprising:

a plurality of temperature sensors coupled to the balloon; and

a single conductive trace connected to each of the plurality of temperature sensors.

14. The medical device of claim 11, wherein the plurality of electrodes comprises more than four electrodes.

20. A method for ablating renal nerves, the method comprising:

advancing the medical device of claim 11 through a blood vessel to a position within a renal artery;

expanding the expandable balloon;

activating one of the plurality of electrodes; and

automatically maintaining the remaining electrodes of the plurality of electrodes as inactive so as to function as ground electrodes,

thereby performing renal nerve ablation.