×

Compositions and methods to affect skin irritation

  • US 9,833,469 B2
  • Filed: 12/21/2016
  • Issued: 12/05/2017
  • Est. Priority Date: 12/28/2015
  • Status: Active Grant
First Claim
Patent Images

1. A composition comprising:

  • (a) at least one topical irritating agent comprising a retinoid, a retinoid derivative, or a retinoid precursor, wherein the retinoid, retinoid derivative and the retinoid precursor are selected from the group consisting of retinol, retinal, retinyl esters, tretinoin, retinoic acid, Vitamin A, ester of Vitamin A, isotretinoin, alitretinoin, etretinate, acitretin, adapalene, bexarotene, and tazarotene, and combinations thereof, and(b) at least one chitosan covalently modified with octane sulfonic acid via sulfonamide linkage, andwherein the composition provides a reduction in skin irritation and/or a reduction in skin inflammation and/or a reduction in irritant-induced IL-1α

    secretion after contact with the composition compared with a control composition comprising the topical irritating agent but not the chitosan.

View all claims
  • 2 Assignments
Timeline View
Assignment View
    ×
    ×