Occlusion detection in delivery of fluids

• US 9,833,561 B2
• Filed: 12/19/2013
• Issued: 12/05/2017
• Est. Priority Date: 12/31/2012
• Status: Active Grant

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: Gambro Lundia AB (Baxter International Inc.)
• Inventors: Chambers, Joshua, O'Mahony, John
• Primary Examiner(s): Walsh, Ryan
• Application Number:
  US14/655,182
• Publication Number:
  US 20150374902A1
• Time in Patent Office: 1,447 Days
• CPC Class Codes: A61M 1/3672 Means preventing coagulation
• CPC Class Codes: A61M 1/3673 Anticoagulant coating, e.g. Heparin coating
• CPC Class Codes: A61M 2005/16863 Occlusion detection
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/332 Force measuring means
• CPC Class Codes: A61M 2209/02 Equipment for testing the apparatus
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/16854 by monitoring line pressure
• CPC Class Codes: A61M 5/16859 Evaluation of pressure response, e.g. to an applied pulse
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: F04B 51/00 Testing machines, pumps, or pumping installations

Abstract

A system, method or apparatus to detect abnormalities in delivery of a fluid may include an infusion apparatus that is controllable to cause one or more perturbations in a fluid flow (e.g., each of the one or more perturbations in the fluid flow may result in a measurable perturbed force response). A force signal representative of the perturbed force response may be used to determine an integrated perturbed force response value (e.g., using integration of the force signal over a perturbation time period; the integrated perturbed force response value being representative of an additional force caused by the at least one perturbation over an equilibrium force). A ratio between the integrated perturbed force response value and a normalizing value (e.g., based at least on a maximum perturbation force of the perturbed force response) may be used to determine if fluid flow is occluded.

Claims

1. A system to detect abnormalities in delivery of a fluid comprising:

an infusion apparatus controllable to provide a fluid flow at an infusion flow rate, wherein the infusion apparatus is further controllable to intermittently deliver a defined volume of fluid resulting in one or more perturbations in the fluid flow;

a force transducer configured to measure a perturbed force response over time resulting from each of the one or more perturbations; and

a controller configured to;

control the infusion apparatus to provide a fluid flow at an infusion flow rate and to cause one or more perturbations in the fluid flow, wherein each of the one or more perturbations in the fluid flow result in a measurable perturbed force response;

receive a force signal representative of a perturbed force response comprising at least a maximum perturbation force resulting from at least one perturbation caused in the fluid flow;

determine an integrated perturbed force response value using integration of the force signal over a perturbation time period, the integrated perturbed force response value being representative of an additional force caused by the at least one perturbation over an equilibrium force;

provide a unitless ratio corresponding to the at least one perturbation between the integrated perturbed force response value and a normalizing value, wherein the normalizing value is based at least on the maximum perturbation force; and

determine fluid flow occlusion based on the unitless ratio corresponding to the at least one perturbation.

2. The system of claim 1, wherein to determine fluid flow occlusion based on the unitless ratio corresponding to the at least one perturbation comprises comparing the ratio to a predetermined ratio indicative of an occlusion.

3. The system of claim 2, wherein a unitless ratio between an integrated perturbed force response value and a normalizing value is provided for each of a plurality of perturbations caused in the fluid flow, and further wherein determining fluid flow occlusion comprises determining whether fluid flow is occluded based on whether a predetermined number of unitless ratios corresponding to multiple adjacent sequential perturbations, when compared to the predetermined ratio, indicate an occlusion.

4. The system of claim 1, wherein the integrated perturbed force response value is representative of an integration, taken over the perturbation time period, of the force signal representative of the perturbed force response taking into consideration the equilibrium force, the integration initiated at the maximum perturbation force.

5. The system of claim 4, wherein the normalizing value is representative of an integration, taken over the perturbation time period, of the maximum perturbation force relative to equilibrium force, the integration initiated at the maximum perturbation force.

6. The system of claim 4, wherein the normalizing value is representative of an integration, over the perturbation time period, of the force signal representative of the perturbed force response relative to the maximum force signal, the integration initiated at the maximum perturbation force.

7. The system of claim 1, wherein the integrated perturbed force response value is representative of an integration, over the perturbation time period, of the force signal representative of the perturbed force response relative to the maximum force signal, the integration initiated at the maximum perturbation force.

8. The system of claim 7, wherein the normalizing value is representative of an integration, taken over the perturbation time period, of the maximum perturbation force relative to equilibrium force, the integration initiated at the maximum perturbation force.

9. The system of claim 1, wherein the normalizing value is determined based on the perturbed force response of the fluid flow as if a substantially total occlusion were present.

10. The system of claim 1, wherein an alarm is configured to be activated upon determination of an occluded fluid flow.

11. The system of claim 1, wherein infusion apparatus comprises a syringe pump.

12. The system of claim 11, wherein the infusion apparatus is configured to infuse an anticoagulant into an extracorporeal blood circuit.

13. An apparatus for extracorporeal blood treatment comprising the system of claim 1.

14. A method to detect abnormalities in delivery of a fluid from an infusion apparatus, wherein the method comprises:

providing a fluid flow at an infusion flow rate;

intermittently delivering a defined volume of fluid causing at least one perturbation in the fluid flow, wherein the at least one perturbation in the fluid flow results in a perturbed force response over time;

measuring the perturbed force response comprising at least a maximum perturbation force resulting from the at least one perturbation caused in the fluid flow and generating a force signal representative thereof;

determining an integrated perturbed force response value using integration of the force signal over a perturbation time period, the integrated perturbed force response value being representative of an additional force caused by the at least one perturbation over an equilibrium force;

providing a unitless ratio corresponding to the at least one perturbation between the integrated perturbed force response value and a normalizing value, wherein the normalizing value is based at least on the maximum perturbation force; and

determining fluid flow occlusion based on the unitless ratio corresponding to the at least one perturbation.

15. The method of claim 14, wherein determining fluid flow occlusion based on the unitless ratio corresponding to the at least one perturbation comprises comparing the unitless ratio to a predetermined ratio indicative of an occlusion.

16. The method of claim 14, wherein the integrated perturbed force response value is representative of an integration, taken over the perturbation time period, of the force signal representative of the perturbed force response taking into consideration the equilibrium force, the integration initiated at the maximum perturbation force.

17. The method of claim 14, wherein the normalizing value is determined based on the perturbed force response of the fluid flow as if a substantially total occlusion were present.

18. An apparatus for extracorporeal blood treatment configured to perform the method of claim 14.

19. An extracorporeal blood treatment apparatus comprising:

an extracorporeal blood circuit;

a syringe pump controllable to provide a fluid flow into the extracorporeal blood circuit at an infusion flow rate, wherein the fluid flow comprises an anticoagulant, and further wherein the syringe pump further controllable to intermittently deliver a defined volume of fluid resulting in one or more perturbations in the fluid flow;

a force transducer configured to measure a perturbed force response over time resulting from each of the one or more perturbations; and

a controller configured to;

control the syringe pump to provide a fluid flow at an infusion flow rate and to cause one or more perturbations in the fluid flow, wherein each of the one or more perturbations in the fluid flow result in a measurable perturbed force response;

receive a force signal representative of a perturbed force response comprising at least a maximum perturbation force resulting from at least one perturbation caused in the fluid flow;

determine an integrated perturbed force response value using integration of the force signal over a perturbation time period, the integrated perturbed force response value being representative of an additional force caused by the at least one perturbation over an equilibrium force;

provide a unitless ratio corresponding to the at least one perturbation between the integrated perturbed force response value and a normalizing value, wherein the normalizing value is based at least on the maximum perturbation force; and

determine fluid flow occlusion based on the unitless ratio corresponding to the at least one perturbation.

20. The apparatus of claim 19, wherein the normalizing value is determined based on the perturbed force response of the fluid flow as if a substantially total occlusion were present.