Modulation of sirtuins by vagus nerve stimulation
First Claim
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1. A method of modulating sirtuin (SIRT) activity and/or level in a patient, the method comprising measuring a level of SIRT in the patient;
- identifying that the patient is in need of SIRT modulation based at least in part on the measured level of SIRT; and
modulating SIRT activity and/or level by applying stimulation to the patient'"'"'s vagus nerve from an implanted micro stimulator.
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Abstract
Systems, devices and methods for modulation of sirtuins by neurostimulation. In particular, sirtuins may be modulated by stimulation of the vagus nerve. Further described herein generally are methods, systems and devices, for specifically modulating sirtuins, including sub-sets (types or localized regions) of sirtuins by vagus nerve stimulation (VNS).
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Citations
24 Claims
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1. A method of modulating sirtuin (SIRT) activity and/or level in a patient, the method comprising measuring a level of SIRT in the patient;
- identifying that the patient is in need of SIRT modulation based at least in part on the measured level of SIRT; and
modulating SIRT activity and/or level by applying stimulation to the patient'"'"'s vagus nerve from an implanted micro stimulator. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- identifying that the patient is in need of SIRT modulation based at least in part on the measured level of SIRT; and
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10. A method of treating a disorder by modulating sirtuin (SIRT activity and/or level in a patient, the method comprising measuring a level of SIRT in the patient;
- identifying that the patient is in need of SIRT modulation based at least in part on the measured level of SIRT; and
modulating SIRT activity and/or level by applying stimulation from a stimulator to stimulate the vagus nerve. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
- identifying that the patient is in need of SIRT modulation based at least in part on the measured level of SIRT; and
Specification