Treatment of interferon regulatory factor 8 (IRF8) related diseases by inhibition of natural antisense transcript to IRF8
First Claim
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1. A synthetic, modified oligonucleotide of 12-30 nucleotides in length comprising at least one optional modification wherein the at least one modification is selected from:
- at least one modified sugar moiety;
at least one modified internucleotide linkage;
at least one modified nucleotide, and combinations thereof;
wherein said oligonucleotide is an antisense compound which specifically hybridizes to a complementary region of a natural antisense polynucleotide of the Interferon Regulatory Factor 8 (IRF8) polynucleotide selected from SEQ ID NO;
2 and upregulates the function and/or expression of a Interferon Regulatory Factor 8 (IRF8) gene in vivo or in vitro as compared to a normal control.
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Abstract
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Interferon Regulatory Factor 8 (IRF8), in particular, by targeting natural antisense polynucleotides of Interferon Regulatory Factor 8 (IRF8). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IRF8.
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15 Claims
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1. A synthetic, modified oligonucleotide of 12-30 nucleotides in length comprising at least one optional modification wherein the at least one modification is selected from:
- at least one modified sugar moiety;
at least one modified internucleotide linkage;
at least one modified nucleotide, and combinations thereof;
wherein said oligonucleotide is an antisense compound which specifically hybridizes to a complementary region of a natural antisense polynucleotide of the Interferon Regulatory Factor 8 (IRF8) polynucleotide selected from SEQ ID NO;
2 and upregulates the function and/or expression of a Interferon Regulatory Factor 8 (IRF8) gene in vivo or in vitro as compared to a normal control. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
- at least one modified sugar moiety;
Specification