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Treatment of interferon regulatory factor 8 (IRF8) related diseases by inhibition of natural antisense transcript to IRF8

  • US 9,834,767 B2
  • Filed: 12/24/2014
  • Issued: 12/05/2017
  • Est. Priority Date: 01/04/2010
  • Status: Expired due to Fees
First Claim
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1. A synthetic, modified oligonucleotide of 12-30 nucleotides in length comprising at least one optional modification wherein the at least one modification is selected from:

  • at least one modified sugar moiety;

    at least one modified internucleotide linkage;

    at least one modified nucleotide, and combinations thereof;

    wherein said oligonucleotide is an antisense compound which specifically hybridizes to a complementary region of a natural antisense polynucleotide of the Interferon Regulatory Factor 8 (IRF8) polynucleotide selected from SEQ ID NO;

    2 and upregulates the function and/or expression of a Interferon Regulatory Factor 8 (IRF8) gene in vivo or in vitro as compared to a normal control.

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