Syringe for obtaining nano-sized materials for selective assays and related methods of use

• US 9,834,809 B2
• Filed: 02/28/2014
• Issued: 12/05/2017
• Est. Priority Date: 02/28/2014
• Status: Expired due to Fees

• Current Assignee: Lockheed Martin Corporation (Martin Marietta Corporation)
• Original Assignee: Lockheed Martin Corporation (Martin Marietta Corporation)
• Inventors: Mountcastle, Paul D., Foulke, Svetlana M., Stetson, Jr., John B.
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): FISHER, BRITTANY I
• Application Number:
  US14/193,007
• Publication Number:
  US 20150247178A1
• Time in Patent Office: 1,376 Days
• Field of Search: 422524, 422525, 422508, 422509, 422511, 422515
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150236 Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
• CPC Class Codes: A61B 5/150244 Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
• CPC Class Codes: A61B 5/150732 Needle holders, for instance for holding the needle by the hub, used for example with double-ended needle and pre-evacuated tube,
• CPC Class Codes: A61B 5/150755 Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61B 5/153 Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: C12Q 1/24 Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms

Abstract

A syringe for obtaining nano-sized components from a solution includes a barrel having an interior, a needle extending from one end of the barrel, and a plunger received in the interior at an end of the barrel opposite the needle. A filter cartridge is positioned between the needle and the barrel, wherein the filter cartridge maintains at least one membrane having apertures of two distinct size ranges, and wherein operation of the plunger to draw the solution into the barrel allows for retention of nano-sized components of a size between the two distinct size ranges.

Claims

1. A syringe for obtaining nano-sized components from a solution, comprising:

a barrel having a barrel interior;

a needle extending from one end of the barrel;

a plunger received in the barrel interior at an end of the barrel opposite the needle;

a filter cartridge maintained between the needle and the barrel, the filter cartridge having at least one membrane having apertures of a first distinct size range and apertures of a second distinct size range, and

wherein the apertures of the first distinct size range are positioned on one half of the at least one membrane and the apertures of the second distinct size range are positioned on an opposite half of the at least one membrane, and

wherein the apertures of the first distinct size range are larger than the apertures of the second distinct size range.

2. The syringe according to claim 1, wherein the at least one membrane is graphene and the apertures of the first distinct aperture size range are 10 to 1000 angstroms in diameter and the apertures of the second distinct aperture size range are 10 to 1000 angstroms in diameter.

3. The syringe according to claim 2, wherein the apertures of the first distinct size range and the apertures of the second distinct size range are sized to capture nano-sized components in a range up to 40 angstroms.

4. The syringe according to claim 1, wherein:

The syringe further comprises a hub connected to an end of the filter cartridge opposite a needle end of the barrel.

5. The syringe according to claim 4, wherein the at least one membrane is in the second position when the solution previously drawn into the barrel interior is pushed out of the barrel interior through the flow path by the plunger, the barrel retaining components that are sized between the first distinct size range and the second distinct size range.

6. The syringe according to claim 1, wherein the filter cartridge further comprises a knob shaft configured to move the at least one membrane between the first position and the second position.

7. A syringe for obtaining nano-sized components from a solution, comprising:

a barrel having a barrel interior;

a needle extending from one end of the barrel;

a plunger received in the barrel interior at an end of the barrel opposite the needle;

a filter cartridge maintained between the needle and the barrel, the filter cartridge comprising;

a chamber movable between a first position and a second position;

a first membrane having apertures of a first distinct size range, the first membrane being disposed on one side of the chamber; and

a second membrane having apertures of a second distinct size range, the second membrane being disposed on an opposite side of said chamber; and

a flow path across the chamber from the needle to the barrel interior,

wherein, in the first position, the first membrane is in the flow path, and

wherein, in the second position, the second membrane is in the flow path.

8. The syringe according to claim 7, wherein the first membrane is positioned closest to the needle and the first distinct size range is larger than the second distinct size range.

9. The syringe according to claim 8, wherein the chamber retains components sized between the first distinct size range and the second distinct size range.

10. The syringe according to claim 7, wherein the filter cartridge further comprises a geared knob configured to move the chamber between the first position and the second position.