Liquid drug transfer devices

• US 9,839,580 B2
• Filed: 08/20/2013
• Issued: 12/12/2017
• Est. Priority Date: 08/26/2012
• Status: Active Grant

• Current Assignee: West Pharma. Services IL, Ltd. (West Pharmaceutical Services Incorporated)
• Original Assignee: Medimop Medical Projects Ltd. (West Pharmaceutical Services Incorporated)
• Inventors: Lev, Nimrod, Ben Shalom, Niv
• Primary Examiner(s): Wiest, Philip R
• Application Number:
  US14/423,595
• Publication Number:
  US 20150209230A1
• Time in Patent Office: 1,575 Days
• Field of Search: 604403-416
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61J 1/1406 Septums, pierceable membranes
• CPC Class Codes: A61J 1/20 Arrangements for transferring or mixing fluids, e.g. from vial to syringe
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2013 having two piercing ends
• CPC Class Codes: A61J 1/2048 Connecting means
• CPC Class Codes: A61J 1/2051 having tap means, e.g. tap means activated by sliding
• CPC Class Codes: A61J 1/2055 having gripping means
• CPC Class Codes: A61J 1/2089 Containers or vials which are to be joined to each other in order to mix their contents combinations of vial and syringe for mixing their contents A61J1/2096
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents

Abstract

Liquid drug transfer devices with universal drug vial adapters for use with a drug vial of a small drug vial and a large drug vial. Some universal drug vial adapters employ the same generally opposite upright flex members for clamping a small drug vial and a large drug vial. Other universal drug vial adapters include a set of minor flex members for clamping a small drug vial and a set of major flex members encircling the set of minor flex members for clamping a large drug vial whereupon the large drug vial underlies the set of minor flex members. Liquid drug transfer devices with a universal injection port connector for attachment on an injection port of an infusion bag.

Claims

1. A liquid drug transfer device for use with a drug vial of a small drug vial and a large drug vial, the drug vial including a drug vial bottle, a drug vial interior, a drug vial stopper, an uppermost drug vial surface, and a drug vial closure,

the small drug vial having a drug vial closure with an external diameter D1 and the large drug vial having a drug vial closure with an external diameter D2 where D2>

D1 and the difference D2−

D1 is in the range of between 4 mm and 7 mm,

the liquid drug transfer device comprising an universal drug vial adapter having a longitudinal drug vial adapter axis and a skirt for telescopically clamping on the drug vial closure,

said skirt including a top wall transverse to said longitudinal drug vial adapter axis, a first pair of axial directed, spaced apart flex member supports and a second pair of axial directed, spaced apart flex member supports opposite said first pair of axial directed flex member supports for defining a drug vial cavity for snugly telescopically receiving at least a top part of a large drug vial therein,

each flex member support having a proximate end adjacent said top wall and a distal end remote from said top wall,

said first pair of flex member supports including a first crosspiece extending between their corresponding distal ends, said first crosspiece integrally formed with an axial directed first flex member resiliently flexibly mounted thereon with respect to said longitudinal drug vial adapter axis, said first flex member having a first flex member free end remote from said first crosspiece and being axially directed and extending generally parallel to said longitudinal drug vial adapter axis from said first crosspiece to said first flex member free end, said first flex member further having an inward radial directed first drug vial grip,

said second pair of flex member supports including a second crosspiece extending between their corresponding distal ends, said second crosspiece integrally formed with an axial directed second flex member resiliently flexibly mounted thereon with respect to said longitudinal drug vial adapter axis, said second flex member having a second flex member free end remote from said crosspiece and being axially directed and extending generally parallel to said longitudinal drug vial adapter axis from said second crosspiece to said second flex member free end, said second flex member further having an inward radial directed second drug vial grip,

said first flex member and said second flex member being opposite such that said first drug vial grip and said second drug vial grip define a separation S therebetween where S<

D1 whereupon said first drug vial grip and said second drug vial grip underlie a drug vial closure on telescopically clamping said universal drug vial adapter on the drug vial,

said first flex member and said second flex member being outwardly resiliently flexed correspondingly at said first crosspiece and said second crosspiece with respect to said longitudinal drug vial adapter axis to a greater extent on telescopically clamping said universal drug vial adapter on the large drug vial compared to telescopically clamping said universal drug vial adapter on the small drug vial.

2. The device according to claim 1, wherein said skirt includes a single continuous annular support including said first crosspiece, said second crosspiece, a third crosspiece extending between said first crosspiece and said second crosspiece, and a fourth crosspiece extending between said first crosspiece and said second crosspiece and opposite said third crosspiece,

said third crosspiece integrally formed with a third flex member resiliently flexibly mounted thereon with respect to said longitudinal drug vial adapter axis, said third flex member having a third flex member free end remote from said third crosspiece and being axially directed and extending generally parallel to said longitudinal drug vial adapter axis between said third crosspiece and said third flex member free end, said third flex member further having an inward radial directed third drug vial grip, and

said fourth crosspiece integrally formed with a fourth flex member resiliently flexibly mounted thereon with respect to said longitudinal drug vial adapter axis, said fourth flex member having a fourth flex member free end remote from said fourth crosspiece and being axially directed and extending generally parallel to said longitudinal drug vial adapter axis between said fourth crosspiece and said fourth flex member free end, said fourth flex member further having an inward radial directed fourth drug vial grip,

said third flex member and said fourth flex member being opposite such that said third drug vial grip and said fourth drug vial grip define said separation S therebetween whereupon said third drug vial grip and said fourth drug vial grip underlie the drug vial closure on telescopically clamping said universal drug vial adapter on the drug vial.

3. The device according to claim 1, wherein said top wall is constituted by an annular centerpiece and a radial strut from said annular centerpiece to each said flex member support.

4. The device according to claim 1, wherein said flex members are arranged to be generally parallel to said longitudinal drug vial adapter axis prior to telescopically clamping said universal drug vial adapter on a drug vial such that said first flex member and said second flex member are generally parallel to said longitudinal drug vial adapter axis on telescopically clamping said universal drug vial adapter on a small drug vial and are outwardly flexed with respect to said longitudinal drug vial adapter axis on telescopically mounting said universal drug vial adapter on a large drug vial.

5. The device according to claim 1, wherein said top wall includes an integral access port and an integral puncturing member in flow communication with said integral access port for puncturing a drug vial stopper on telescopic clamping said universal drug vial adapter on the drug vial for enabling flow communication with the drug vial interior.

6. The device according to claim 1, wherein said universal drug vial adapter is capable of being telescopically clamped on a pre-attached initially intact drug vial, said top wall including an axial directed tubular stem overlying the uppermost drug vial surface of the pre-attached initially intact drug vial,

the liquid drug transfer device further comprising a discrete liquid transfer member with a puncturing tip disposed in said stem for puncturing the drug vial stopper on downward urging said liquid transfer member towards the drug vial for enabling flow communication with the drug vial interior.

7. The device according to claim 6, wherein said pre-attached intact drug vial is removable intact from said universal drug vial adapter on employing a drug vial release tool for outwardly flexing said flex members relative to said longitudinal drug vial adapter axis.

8. The device according to claim 1, wherein D1 is between 13 mm and 14 mm and D2 is between 20 mm and 21 mm.

9. A liquid drug transfer device for use with a drug vial of a small drug vial and a large drug vial, the drug vial including a drug vial bottle, a drug vial interior, a drug vial stopper, an uppermost drug vial surface, and a drug vial closure,

the small drug vial having a drug vial closure with an external diameter D1 and the large drug vial having a drug vial closure with an external diameter D2 where D2>

D1,

the liquid drug transfer device comprising an universal drug vial adapter having a longitudinal drug vial adapter axis and a skirt for telescopically clamping on the drug vial closure,

said skirt including a top wall transverse to said longitudinal drug vial adapter axis, a first pair of axial directed, spaced apart flex member supports and a second pair of axial directed, spaced apart flex member supports opposite said first pair of axial directed flex member supports for defining a drug vial cavity for snugly telescopically receiving at least a top part of a large drug vial therein,

each flex member support having a proximate end adjacent said top wall and a distal end remote from said top wall,

said first pair of flex member supports including a first crosspiece extending between their corresponding distal ends, said first crosspiece integrally formed with an axial directed first flex member resiliently flexibly mounted thereon with respect to said longitudinal drug vial adapter axis, said first flex member having a first flex member free end remote from said first crosspiece and being axially directed and extending generally parallel to said longitudinal drug vial adapter axis from said first crosspiece to said first flex member free end, said first flex member further having an inward radial directed first drug vial grip,

said second pair of flex member supports including a second crosspiece extending between their corresponding distal ends, said second crosspiece integrally formed with an axial directed second flex member resiliently flexibly mounted thereon with respect to said longitudinal drug vial adapter axis, said second flex member having a second flex member free end remote from said crosspiece and being axially directed and extending generally parallel to said longitudinal drug vial adapter axis from said second crosspiece to said second flex member free end, said second flex member further having an inward radial directed second drug vial grip,

said first flex member and said second flex member being opposite such that said first drug vial grip and said second drug vial grip define a separation S therebetween where S<

D1 whereupon said first drug vial grip and said second drug vial grip underlie a drug vial closure on telescopically clamping said universal drug vial adapter on the drug vial,

said first flex member and said second flex member being outwardly resiliently flexed correspondingly at said first crosspiece and said second crosspiece with respect to said longitudinal drug vial adapter axis to a greater extent on telescopically clamping said universal drug vial adapter on the large drug vial compared to telescopically clamping said universal drug vial adapter on the small drug vial.

10. The device according to claim 9, wherein said skirt includes a single continuous annular support including said first crosspiece, said second crosspiece, a third crosspiece extending between said first crosspiece and said second crosspiece, and a fourth crosspiece extending between said first crosspiece and said second crosspiece and opposite said third crosspiece,

said third crosspiece integrally formed with a third flex member resiliently flexibly mounted thereon with respect to said longitudinal drug vial adapter axis, said third flex member having a third flex member free end remote from said third crosspiece and being axially directed and extending generally parallel to said longitudinal drug vial adapter axis between said third crosspiece and said third flex member free end, said third flex member further having an inward radial directed third drug vial grip, and

said fourth crosspiece integrally formed with a fourth flex member resiliently flexibly mounted thereon with respect to said longitudinal drug vial adapter axis, said fourth flex member having a fourth flex member free end remote from said fourth crosspiece and being axially directed and extending generally parallel to said longitudinal drug vial adapter axis between said fourth crosspiece and said fourth flex member free end, said fourth flex member further having an inward radial directed fourth drug vial grip,

said third flex member and said fourth flex member being opposite such that said third drug vial grip and said fourth drug vial grip define said separation S therebetween whereupon said third drug vial grip and said fourth drug vial grip underlie the drug vial closure on telescopically clamping said universal drug vial adapter on the drug vial.

11. The device according to claim 9, wherein said top wall is constituted by an annular centerpiece and a radial strut from said annular centerpiece to each said flex member support.

12. The device according to claim 9, wherein said flex members are arranged to be generally parallel to said longitudinal drug vial adapter axis prior to telescopically clamping said universal drug vial adapter on a drug vial such that said first flex member and said second flex member are generally parallel to said longitudinal drug vial adapter axis on telescopically clamping said universal drug vial adapter on a small drug vial and are outwardly flexed with respect to said longitudinal drug vial adapter axis on telescopically mounting said universal drug vial adapter on a large drug vial.

13. The device according to claim 9, wherein said top wall includes an integral access port and an integral puncturing member in flow communication with said integral access port for puncturing a drug vial stopper on telescopic clamping said universal drug vial adapter on the drug vial for enabling flow communication with the drug vial interior.

14. The device according to claim 9, wherein said universal drug vial adapter is capable of being telescopically clamped on a pre-attached initially intact drug vial, said top wall including an axial directed tubular stem overlying the uppermost drug vial surface of the pre-attached initially intact drug vial,

the liquid drug transfer device further comprising a discrete liquid transfer member with a puncturing tip disposed in said stem for puncturing the drug vial stopper on downward urging said liquid transfer member towards the drug vial for enabling flow communication with the drug vial interior.

15. The device according to claim 14, wherein said pre-attached intact drug vial is removable intact from said universal drug vial adapter on employing a drug vial release tool for outwardly flexing said flex members relative to said longitudinal drug vial adapter axis.