Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
First Claim
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1. A pharmaceutical formulation consisting of:
- (a) 3.5 mg/mL insulin aspart;
(b) 31.62 mg/mL sorbitol;
(c) 1.72 mg/mL metacresol;
(d) 1.50 mg/mL phenol;
(e) 0.0196 mg/mL Zn(II);
(f) 0.58 mg/mL sodium chloride;
(g) 1.88 mg/mL Na2HPO4×
7 H2O;
(h) sodium hydroxide and/or hydrochloric acid to adjust the pH to 7.4; and
(i) water.
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Abstract
Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives are disclosed.
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Citations
14 Claims
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1. A pharmaceutical formulation consisting of:
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(a) 3.5 mg/mL insulin aspart; (b) 31.62 mg/mL sorbitol; (c) 1.72 mg/mL metacresol; (d) 1.50 mg/mL phenol; (e) 0.0196 mg/mL Zn(II); (f) 0.58 mg/mL sodium chloride; (g) 1.88 mg/mL Na2HPO4×
7 H2O;(h) sodium hydroxide and/or hydrochloric acid to adjust the pH to 7.4; and (i) water. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification