System and method for mapping arbitrary electric fields to pre-existing lead electrodes

• US 9,839,780 B2
• Filed: 10/05/2015
• Issued: 12/12/2017
• Est. Priority Date: 11/03/2009
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Moffitt, Michael A., Kothandaraman, Sridhar, Rao, Prakash
• Primary Examiner(s): KAHELIN, MICHAEL WILLIAM
• Application Number:
  US14/874,824
• Publication Number:
  US 20160059017A1
• Time in Patent Office: 799 Days
• CPC Class Codes: A61B 34/10 Computer-aided planning, simulation or modelling of surgical operations
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0553 Paddle shaped electrodes, e.g. for laminotomy
• CPC Class Codes: A61N 1/3616 Voltage density or current density
• CPC Class Codes: A61N 1/36182 Direction of the electrical field, e.g. with sleeve around stimulating electrode
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/37235 Aspects of the external programmer
• CPC Class Codes: A61N 1/37241 providing test stimulations
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means
• CPC Class Codes: A61N 1/37252 Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data
• CPC Class Codes: G16H 20/30 relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• CPC Class Codes: G16H 40/67 for remote operation
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

A system for a neurostimulator coupled to electrodes, and a method of providing therapy to a patient using the electrodes implanted within the patient. A target multipole relative to the electrodes is defined. The target multipole is emulated by defining an initial electrical current distribution for the electrodes, such that a first set of active electrodes respectively has electrical current values of a first polarity. Each of the electrical current values of the first polarity is compared to a first threshold value, and at least one of the electrodes in the first active electrode set is zeroed-out based on the comparison. The electrical current value of each of the zeroed-out electrode(s) is redistributed to remaining ones of the electrodes to define a new electrical current distribution for the electrodes. Electrical current is conveyed to the electrodes in accordance with the new electrical current distribution, thereby providing the therapy.

Claims

1. A neurostimulation system for use with an electrical neurostimulator coupled to a plurality of electrodes, the system comprising:

an external control device configured to;

define an initial electrical current distribution for the plurality of electrodes to emulate a target field such that each electrode in the plurality of electrodes has its own fractionalized electrical current value that is a portion of a total current value;

identify, based on the initial electrical current distribution, a subset of the plurality of electrodes to be used for a new electrical current distribution, wherein the plurality of electrodes includes an omitted electrode that is not within the subset;

modify the initial electrical current distribution for the plurality of electrodes into a new electrical current distribution for the subset, including redistribute an electrical current value of the omitted electrode to one or more electrodes within the subset; and

generate instructions for the electrical neurostimulator to convey electrical current to the plurality of electrodes in accordance with the new electrical current distribution,

wherein to identify the subset of the plurality of electrodes, the external control device is configured to identify a group of at least one electrode that has a lower current contribution to the total current value than the remainder of the plurality of electrodes, and wherein to identify the group, the external control device is configured to compare fractionalized electrical current values to a threshold value.

2. The system of claim 1, wherein the initial electrical current distribution provides electrical current values of a first polarity for some of the plurality of electrodes, and provides electrical current values of a second polarity for others of the plurality of electrodes, the external control device further configured to compare the fractionalized electrical current values for the first polarity to a first threshold for the first polarity and compare the fractionalized electrical current values for the second polarity to a second threshold for the second polarity.

3. The system of claim 2, wherein the first threshold for the first polarity has a first magnitude and the second threshold for the second polarity has a second magnitude equal to the first magnitude.

4. The system of claim 2, wherein the first threshold for the first polarity has a first magnitude and the second threshold for the second polarity has a second magnitude different from the first magnitude.

5. The system of claim 1, wherein the external control device is configured to determine the threshold value as a function of the fractionalized electrical current values.

6. The system of claim 1, wherein the external control device is configured to determine the threshold value using a statistical measure of variance of the fractionalized electrical current values.

7. The system of claim 6, wherein the external control device is configured to determine a first threshold value as a function of a standard deviation less than the highest fractionalized electrical current value of a first polarity.

8. The system of claim 1, wherein the external control device is configured to use a target bipole or a target tripole to emulate the target field.

9. A method, comprising:

defining an initial electrical current distribution for the plurality of electrodes to emulate a target field such that each electrode in the plurality of electrodes has its own fractionalized electrical current value that is a portion of a total current value;

identifying, based on the initial electrical current distribution, a subset of the plurality of electrodes to be used for a new electrical current distribution, wherein the plurality of electrodes includes an omitted electrode that is not within the subset;

modifying the initial electrical current distribution for the plurality of electrodes into a new electrical current distribution for the subset, including redistributing an electrical current value of the omitted electrode to one or more electrodes within the subset; and

generating instructions for the electrical neurostimulator to convey electrical current in accordance with the new electrical current distribution,

wherein identifying the subset of the plurality of electrodes includes identifying a group of at least one electrode that has a lower current contribution to the total current value than the remainder of the plurality of electrodes, and wherein identifying the group of at least one electrode includes comparing fractionalized electrical current values to a threshold value.

10. The method of claim 9, wherein the initial electrical current distribution provides electrical current values of a first polarity for some of the plurality of electrodes, and provides electrical current values of a second polarity for others of the plurality of electrodes, the method includes comparing the fractionalized electrical current values to a threshold value includes comparing the electrical current values for the first polarity to a first threshold for the first polarity and comparing the electrical current values for the second polarity to a second threshold for the second polarity.

11. The method of claim 10, wherein the first threshold for the first polarity has a first magnitude and the second threshold for the second polarity has a second magnitude equal to the first magnitude.

12. The method of claim 10, wherein the first threshold for the first polarity has a first magnitude and the second threshold for the second polarity has a second magnitude different from the first magnitude.

13. The method of claim 9, further comprising determining the threshold as a function of the fractionalized electrical current values.

14. The method of claim 9, further comprising determining the threshold using a statistical measure of variance of the fractionalized electrical current values.

15. The method of claim 14, wherein determining the threshold includes determining a first threshold value as a function of a standard deviation less than the highest fractionalized electrical current value of a first polarity.

16. A non-transitory machine-readable medium including instructions, which when executed by a machine, cause the machine to instruct a neuromodulation device to:

define an initial electrical current distribution for the plurality of electrodes to emulate a target field such that each electrode in the plurality of electrodes has its own fractionalized electrical current value that is a portion of a total current value;

identify, based on the initial electrical current distribution, a subset of the plurality of electrodes to be used for a new electrical current distribution, wherein the plurality of electrodes includes an omitted electrode that is not within the subset;

modify the initial electrical current distribution for the plurality of electrodes into a new electrical current distribution for the subset, including redistribute an electrical current value of the omitted electrode to one or more electrodes within the subset; and

generate instructions for the electrical neurostimulator to convey electrical current in accordance with the new electrical current distribution,

wherein identify the subset of the plurality of electrodes includes identify a group of at least one electrode that has a lower current contribution to the total current value than the remainder of the plurality of electrodes, and wherein identify the group of at least one electrode includes compare fractionalized electrical current values to a threshold value.

17. The non-transitory machine-readable medium of claim 16, wherein the initial electrical current distribution provides electrical current values of a first polarity for some of the plurality of electrodes, and provides electrical current values of a second polarity for others of the plurality of electrodes, the external control device further configured to compare the fractionalized electrical current values for the first polarity to a first threshold for the first polarity and compare the fractionalized electrical current values for the second polarity to a second threshold for the second polarity.

18. The non-transitory machine-readable medium of claim 16, wherein the instructions include instructions, which when executed by the machine, cause the machine to determine the threshold value as a function of the fractionalized electrical current values.

19. The non-transitory machine-readable medium of claim 16, wherein the instructions include instructions, which when executed by the machine, cause the machine to determine the threshold value using a statistical measure of variance of the fractionalized electrical current values.

20. The non-transitory machine-readable medium of claim 16, wherein the instructions include instructions, which when executed by the machine, cause the machine to use a target bipole or a target tripole to emulate the target field.