Localization of magnetic particles by means of swift-MRI

• US 9,841,480 B2
• Filed: 04/01/2010
• Issued: 12/12/2017
• Est. Priority Date: 04/02/2009
• Status: Active Grant

• Current Assignee: Regents of The University of Minnesota (University of Minnesota)
• Original Assignee: Regents of The University of Minnesota (University of Minnesota)
• Inventors: Corum, Curtis A., Idiyatullin, Djaudat S., Moeller, Steen, Garwood, Michael G.
• Primary Examiner(s): Koval, Melissa
• Assistant Examiner(s): PATEL, RISHI R
• Application Number:
  US13/262,397
• Publication Number:
  US 20120092010A1
• Time in Patent Office: 2,812 Days
• Field of Search: 324300-322, 600407-422
• CPC Class Codes: G01R 33/4816 NMR imaging of samples with ultrashort relaxation times such as solid samples, e.g. MRI using ultrashort TE [UTE], single point imaging, constant time imaging
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Abstract

Positive contrast localization of magnetic (e.g. superparamagnetic) particles in vivo or in vitro by means of SWIFT-MRI using the imaginary component of MR image data in combination with an anatomic reference image derived from the real or magnitude component.

Claims

1. A system comprising:

a magnetic resonance scanner; and

a processor coupled to the scanner and configured to generate magnetic resonance (MR) image data, the MR image data including complex data having a first component and a second component for a subject, the processor configured to generate a first image using the first component and generate a second image using the second component, the MR image data acquired in a time-share mode and substantially simultaneous with excitation, the excitation including a short T₂ sensitive sequence provided by the scanner, and wherein the first image corresponds to anatomy of the subject and the second image corresponds to a magnetic material within the subject, the first image different from the second image, and the processor configured to identify a position of the magnetic material within the subject based on the second image.

2. The system of claim 1 wherein the processor is configured to iteratively correct for an off-resonance frequency artifact.

3. The system of claim 1 wherein the processor is configured to register the first component and the second component.

4. The system of claim 3 wherein the first component includes at least one of a magnitude component or a real component.

5. A method comprising:

labeling cells of a specimen with a magnetic particle;

generating magnetic resonance (MR) image data for the specimen using swept frequency excitation and substantially simultaneous signal acquisition in a time-shared mode, the MR image data including a first component and a second component;

generating a first image using the first component and generating a second image using the second component, the first image corresponding to an anatomical image of the specimen, the first image different from the second image; and

detecting the labeled cells using the second image and using the first image.

6. The method of claim 5 wherein detecting the labeled cells using the second image includes using at least one of a phase component or an imaginary component.

7. The method of claim 6 wherein generating the first image includes using at least one of a magnitude component or a real component of the MR image data.

8. The method of claim 5 further including using a local frequency shift to correct for an off-resonance artifact during signal acquisition.

9. The method of claim 5 wherein generating MR image data includes performing at least one of SWIFT, SWIFT-LiTE, or UTE.

10. The method of claim 5 wherein detecting the labeled cells includes identifying a position of the labeled cells.

11. A method comprising:

labeling a tissue of a specimen of interest with a magnetic contrast agent;

generating magnetic resonance (MR) image data for the specimen of interest utilizing a short T₂ sensitive MR imaging sequence, the sequence including swept frequency excitation and the image date acquired substantially simultaneous with excitation, the data including a first component and a complementary component, wherein the first component corresponds to an anatomical image of the specimen;

using the data to form a second image corresponding to the complementary component and corresponding to the magnetic contrast agent; and

detecting the labeled tissue using the second image.

12. The method of claim 11 wherein the tissue includes an exogenously labeled cell.

13. The method of claim 11 wherein the contrast agent includes at least one of a molecule or a particle.

14. The method of claim 11 wherein labeling the tissue includes injecting the tissue with a paramagnetic material.

15. The method of claim 14 wherein the paramagnetic material includes a superparamagnetic material.

16. The method of claim 11 wherein the tissue includes intrinsic iron content.

17. The method of claim 16 wherein the intrinsic iron content includes at least one of ferretin, hemoglobin, or a cytochrome.

18. The method of claim 11 wherein detecting the labeled tissue includes identifying a position of labeled cells.

19. The method of claim 11 wherein the complementary component includes at least one of a phase component or an imaginary component.