Intra-lumen polyp detection

• US 9,844,354 B2
• Filed: 02/06/2008
• Issued: 12/19/2017
• Est. Priority Date: 02/06/2007
• Status: Active Grant

• Current Assignee: Check-Cap Ltd.
• Original Assignee: Check-Cap Ltd.
• Inventors: Kimchy, Yoav, Klein, Yitzak, Baum, Gideon, Sommer, Rafi
• Primary Examiner(s): NGUYEN, HIEN NGOC
• Application Number:
  US12/525,672
• Publication Number:
  US 20100174184A1
• Time in Patent Office: 3,604 Days
• Field of Search: 600436
• CPC Class Codes: A61B 6/4057 by using radiation sources located in the interior of the body A61B6/037 takes precedence
• CPC Class Codes: A61B 6/425 using detectors specially adapted to be used in the interior of the body
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 6/485 involving fluorescence X-ray imaging

Abstract

An apparatus and a method for detecting clinically-relevant features of the gastrointestinal (GI) tract of a subject are disclosed. The apparatus includes a capsule to be swallowed by a subject and passing through the GI tract of the subject, a capsule housing, a radiation source emitting radiation, a rotatable collimator configured to rotate with respect to the housing and to collimate the radiation emitted by the radiation source, and a radiation detector configured to detect particles, such as photons, gamma radiation, beta radiation and electrons photons generated responsive to the emitted radiation. The apparatus also includes a control unit configured to analyze data regarding the photons. Movement of the capsule in the GI tract can be detected from a comparison between at least two images acquired with the apparatus. The radiation source, radiation detector and control unit may advantageously be integrated inside a single housing.

Claims

1. An apparatus, comprising:

a capsule configured to be swallowed by a subject and to pass through a gastrointestinal (GI) tract of the subject, the capsule comprising;

a capsule housing;

at least one radiation source configured to emit radiation from the capsule;

a rotatable collimator configured to rotate with respect to the housing and to collimate the radiation emitted by the at least one radiation source;

at least one radiation detector positioned next to the collimator and coupled with the collimator to rotate together, the radiation detector being configured to detect radiation comprising particles generated responsive to the radiation emitted from the capsule, wherein the generated particles that are detected are directed back toward the radiation detector and collimator in an opposite direction of the radiation emitted from the capsule;

electronic circuitry programed to serve as a control unit to analyze data regarding the detected particles; and

a shield for covering and uncovering the radiation source, the shield is configured to rotate with the collimator and detector and comprises wings that cover openings on the shield, the wings are configured to rotate open and expose the radiation source;

wherein the wings are disposed on the shield, within the capsule housing to avoid contact with walls of the gastrointestinal tract; and

wherein the wings are held closed by a spring when the shield is not rotating.

2. The apparatus according to claim 1, wherein the at least one radiation source is configured to emit one or more particles selected from a group consisting of:

photons, gamma radiation, beta radiation and electrons.

3. The apparatus according to claim 1, wherein the at least one radiation detector is configured to detect one or more particles selected from a group consisting of:

photons, Compton backscattering photons, x-ray fluorescence (XRF) photons, and electrons.

4. The apparatus according to claim 1, wherein the control unit analyzes data regarding the detected particles in order to generate information useful for identifying a clinically-relevant feature of the GI tract of the subject.

5. The apparatus according to claim 1, wherein the control unit is configured to detect that the capsule has reached a predetermined area within the GI tract, and to initiate rotation of the collimator in response to detecting that the capsule has reached the predetermined area.

6. The apparatus according to claim 1, wherein the predetermined area is an area of clinical interest.

7. The apparatus according to claim 1, wherein the at least one radiation detector is configured to rotate with respect to the housing and to detect particles generated responsively to the emitted radiation.

8. The apparatus according to claim 1, wherein the control unit is configured to determine tissue density from the analyzed data.

9. The apparatus according to claim 8, wherein the control unit is configured to distinguish between polyps based on the determined tissue density.

10. The apparatus according to claim 1, wherein the control unit is part of the capsule.

11. The apparatus according to claim 1, wherein the at least one radiation detector detects in response to the emitted radiation a first signal and a second signal inside the GI tract of the subject, and wherein the control unit processes the first signal to generate a first image of the GI tract of a region where the first signal was detected, and wherein the control unit processes the second signal to generate a second image of the GI tract of a region where the second signal was detected;

and detects movement of the capsule relative to the GI tract by comparing the first and second generated images.

20. The apparatus according to claim 1, wherein the radiation shield includes a first portion and a second portion, the second portion configured to move relative to the first portion to uncover the radiation source due to centrifugal force induced by rotation of the shield.

12. A method comprising:

orally administering a capsule in a housing to a subject to analyze a gastrointestinal (GI) tract, said capsule comprising a radiation source collimated by a collimator and at least one radiation detector positioned next to the collimator and coupled thereto to rotate together directing the radiation around an inner circumference of a portion of the GI tract;

covering the radiation source, collimator and detector with a shield, the shield having openings covered by wings that can be rotated open to expose the radiation source;

rotating the shield, collimator and detector, causing the wings to rotate open and uncover the openings of the shield exposing the radiation source;

wherein the wings are disposed on the shield, within the capsule housing to avoid contact with walls of the gastrointestinal tract; and

wherein the wings are held closed by a spring when the shield is not rotating;

detecting with the at least one radiation detector radiation generated in response to the radiation emitted from the capsule, wherein generated particles that are detected are directed back toward the radiation detector and collimator in an opposite direction of the radiation emitted from the capsule; and

generating information useful for identifying a clinically-relevant feature of the GI tract of the subject by analyzing data regarding the detected radiation.

13. The method according to claim 12, wherein the emitted radiation comprises particles selected from a group consisting of:

photons, gamma radiation, beta radiation and electrons.

14. The method according to claim 12, wherein the detected radiation comprises particles selected from a group consisting of:

photons, beta radiation, Compton backscattering photons, x-ray fluorescence (XRF) photons, and electrons.

15. The method according to claim 12, wherein the useful information provides an indication of tissue density.

16. The method according to claim 15, and further quantifying the indicated tissue density to distinguish between polyps.

17. The method according to claim 12, further comprising detecting when the collimator has reached a predetermined area, and initiating rotation of the collimator in response to detecting that the collimator has reached the predetermined area.

18. The method of claim 12, wherein said detecting step includes detecting in response to the emitted radiation a first signal and a second signal inside the subject'"'"'s GI tract, the method further comprising:

processing the first signal to generate a first image of the GI tract in a region where the first signal was detected;

processing the second signal to generate a second image of the GI tract in a region where the second signal was detected; and

determining movement of the capsule in the GI tract by comparing the first and second images.

19. The method according to claim 12, wherein the step of rotating the shield includes moving a first portion of the radiation shield relative to a second portion of the radiation shield to uncover the radiation source due to centrifugal force induced by rotation of the shield.