Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same
First Claim
1. A treatment system for cooling subcutaneous lipid-rich cells in a subject, comprising:
- an applicator configured to be in thermal communication with skin of the subject;
a control unit having a cooling state and a heating state, the control unit includingan applicator circulation circuit including a supply end in fluid communication with the applicator and a return end in fluid communication with the applicator, the applicator circulation circuit defining a flow path extending between the supply end and the return end and along which coolant flows to deliver coolant to the applicator,a chiller apparatus configured to chill coolant from the applicator circulation circuit, the chiller apparatus is configured to deliver chilled coolant to the applicator circulation circuit to reduce a temperature of coolant in the applicator circulation circuit from room temperature to a temperature less than 0°
C. while chilled coolant in the chiller apparatus is maintained at a temperature less than 0°
C. when the control unit is in the cooling state, anda heater apparatus configured to deliver heated coolant to the applicator circulation circuit to raise the temperature of the coolant in the applicator circulation circuit when the control unit is in the heating state;
a controller having instructions that, when executed, causes the chiller apparatus to deliver chilled coolant to the applicator circulation circuit such that the coolant cools the applicator enough to keep the subcutaneous lipid-rich cells at or below 0°
C. for a sufficient length of time to disrupt target subcutaneous lipid-rich cells; and
a mixing reservoir along the flow path and configured to hold a sufficient volume of the coolant for cooling the applicator such that the applicator cools target subcutaneous lipid-rich cells to a temperature lower than 0°
C.,wherein the chiller apparatus includes a chilled reservoir configured to hold a sufficient volume of pre-chilled coolant for mixing with and cooling the coolant held in the mixing reservoir to a temperature lower than 0°
C.
3 Assignments
0 Petitions
Accused Products
Abstract
A treatment system for cooling subcutaneous lipid-rich cells in a human subject includes an applicator and a control unit. The treatment system has a cooling mode for cooling tissue and a heating mode for warming tissue. The control unit includes a circulation circuit in fluid communication with the applicator, a chiller apparatus configured to chill fluid from the applicator circulation circuit, and a heater apparatus to warmed fluid from the applicator circulation circuit. The control unit mixes the chilled fluid and/or the warmed with fluid in the applicator circulation circuit control the temperature of the fluid circulated in the applicator.
696 Citations
29 Claims
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1. A treatment system for cooling subcutaneous lipid-rich cells in a subject, comprising:
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an applicator configured to be in thermal communication with skin of the subject; a control unit having a cooling state and a heating state, the control unit including an applicator circulation circuit including a supply end in fluid communication with the applicator and a return end in fluid communication with the applicator, the applicator circulation circuit defining a flow path extending between the supply end and the return end and along which coolant flows to deliver coolant to the applicator, a chiller apparatus configured to chill coolant from the applicator circulation circuit, the chiller apparatus is configured to deliver chilled coolant to the applicator circulation circuit to reduce a temperature of coolant in the applicator circulation circuit from room temperature to a temperature less than 0°
C. while chilled coolant in the chiller apparatus is maintained at a temperature less than 0°
C. when the control unit is in the cooling state, anda heater apparatus configured to deliver heated coolant to the applicator circulation circuit to raise the temperature of the coolant in the applicator circulation circuit when the control unit is in the heating state; a controller having instructions that, when executed, causes the chiller apparatus to deliver chilled coolant to the applicator circulation circuit such that the coolant cools the applicator enough to keep the subcutaneous lipid-rich cells at or below 0°
C. for a sufficient length of time to disrupt target subcutaneous lipid-rich cells; anda mixing reservoir along the flow path and configured to hold a sufficient volume of the coolant for cooling the applicator such that the applicator cools target subcutaneous lipid-rich cells to a temperature lower than 0°
C.,wherein the chiller apparatus includes a chilled reservoir configured to hold a sufficient volume of pre-chilled coolant for mixing with and cooling the coolant held in the mixing reservoir to a temperature lower than 0°
C. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A treatment system for cooling subcutaneous lipid-rich cells in a subject, the treatment system comprising:
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an applicator configured to be in thermal communication the subject'"'"'s skin; a control unit having a cooling state and a heating state, the control unit including an applicator circulation circuit including a supply end in fluid communication with the applicator, a return end in fluid communication with the applicator, and a mixing reservoir positioned along a flow path of the applicator circulation circuit, the flow path extending between the supply end and the return end, a chiller apparatus fluidically coupled to the applicator circulation circuit, the chiller apparatus including a chilled reservoir configured to hold a volume of pre-chilled coolant at a standby temperature that is lower than 0°
C.;a controller in communication with the control unit and the chiller apparatus, the controller containing instructions that, when executed, causes the controller to; command the chiller apparatus to deliver chilled coolant from the chilled reservoir to the mixing reservoir to lower a temperature of coolant contained in the mixing reservoir to a temperature lower than 0°
C., andcommand the applicator circulation circuit to deliver the coolant cooled to a temperature lower than 0°
C. from the mixing reservoir to the applicator such that the applicator cools target subcutaneous lipid-rich cells of the subject to a temperature lower than 0°
C.; andcommand the chiller apparatus to deliver chilled coolant to the applicator circulation circuit to cool the coolant in the applicator circulation circuit to keep the target subcutaneous lipid-rich cells at or below 0°
C. for a sufficient length of time to disrupt the target subcutaneous lipid-rich cells. - View Dependent Claims (23, 24, 25, 26, 27)
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28. A treatment system for cooling subcutaneous lipid-rich cells in a subject, the treatment system comprising:
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an applicator configured to be in thermal communication the subject'"'"'s skin and including at least one temperature sensor, a control unit having a cooling state and a heating state, the control unit including an applicator circulation circuit including a supply end in fluid communication with the applicator, a return end in fluid communication with the applicator, and a mixing reservoir positioned along a flow path of the applicator circulation circuit, the flow path extending between the supply end and the return end, a chiller apparatus fluidically coupled to the applicator circulation circuit, the chiller apparatus including a chilled reservoir configured to hold a volume of pre-chilled coolant at a standby temperature that is lower than 0°
C.;a controller in communication with the at least one temperature sensor and the chiller apparatus, the controller having instructions that, when executed, causes the controller to command the chiller apparatus to deliver chilled coolant from the chilled reservoir to the mixing reservoir to lower a temperature of coolant contained in the mixing reservoir to a temperature lower than 0°
C., andcommand the control unit based on a temperature measurement from the at least one temperature sensor to deliver the coolant, which is at a temperature lower than 0°
C., to the applicator such that the applicator cools target subcutaneous lipid-rich cells of the subject to a temperature lower than 0°
C. for a sufficient length of time to disrupt the target subcutaneous lipid-rich cells. - View Dependent Claims (29)
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Specification