Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants

• US 9,844,461 B2
• Filed: 01/25/2011
• Issued: 12/19/2017
• Est. Priority Date: 01/25/2010
• Status: Active Grant

• Current Assignee: ZELTIQ Aesthetics, Inc. (Abbvie Incorporated)
• Original Assignee: ZELTIQ Aesthetics, Inc. (Abbvie Incorporated)
• Inventors: Levinson, Mitchell E., Allison, John W., Coakley, Joseph, Weber, Bryan
• Primary Examiner(s): Smith, Kaitlyn
• Assistant Examiner(s): Antiskay, Brian M
• Application Number:
  US13/013,603
• Publication Number:
  US 20110238051A1
• Time in Patent Office: 2,520 Days
• Field of Search: 607 96, 607104, 165 46
• CPC Class Codes: A61F 2007/0056 for cooling
• CPC Class Codes: A61F 2007/0096 with a thermometer
• CPC Class Codes: A61F 2007/029 Fat cell removal or destruction by non-ablative heat treatment
• CPC Class Codes: A61F 2007/0292 using latent heat produced or absorbed during phase change of materials, e.g. of super-cooled solutions
• CPC Class Codes: A61F 7/02 Compresses or poultices for effecting heating or cooling

Abstract

Home-use applicators for non-invasively removing heat from subcutaneous, lipid-rich cells via phase change coolants, and associated devices, systems and methods. A device in accordance with a particular embodiment includes an applicator releasably positionable in thermal communication with human skin, and a coolant vessel having a coolant. The device further includes a heat transfer conduit operatively coupled to the applicator and housing a heat transfer fluid that is isolated from fluid contact with the coolant. A heat exchanger is operatively coupled between the coolant vessel and the heat transfer conduit to transfer heat between the heat transfer fluid and the coolant, and a fluid driver is operatively coupled to the heat transfer conduit to direct the heat transfer fluid between the applicator and the heat exchanger.

Claims

1. A cooling device for cooling subcutaneous lipid-rich cells in a human, comprising:

an applicator releasably positionable against human skin, the applicator including;

a flexible, fluid-tight envelope having an entry port, an exit port, a fluid chamber, and first and second oppositely-facing internal surfaces positioned on opposite sides of the fluid chamber; and

a porous internal structure positioned within the envelope between the entry port and the exit port, positioned directly between the first and second internal surfaces of the envelope, and positioned throughout substantially the entire fluid chamber, the internal structure including multiple layers of fibrous material positioned face-to-face such that the layers of fibrous material slidably contact one another along substantially an entire length of the porous internal structure when the flexible, fluid-tight envelope is completely filled with a pressurized fluid, the internal structure;

(a) having a buckling strength sufficient to prevent the envelope from collapsing on itself when the outlet port is exposed to a pressure below a pressure external to the envelope, and

(b) being attached to an inner surface of the envelope to at least restrict the envelope from bulging when a pressurized fluid is applied to an entry port.

2. The device of claim 1 wherein the internal structure has a buckling strength sufficient to prevent the envelope from collapsing on itself when the outlet port is exposed to a pressure of up to 2 psi below a pressure external to the envelope.

3. The device of claim 1 wherein the internal structure has a buckling strength sufficient to prevent the envelope from collapsing on itself when the outlet port is exposed to a pressure of up to 5 psi below a pressure external to the envelope.

6. The device of claim 1 wherein the applicator further comprises attachment elements extending from the first internal surface to the second internal surface.

7. The device of claim 1, further comprising:

a heat exchanger operably coupled to the applicator; and

a pump having an inlet coupled to the exit port of the applicator to draw fluid from the applicator, and an outlet upstream of the heat exchanger.

8. The device of claim 1, further comprising:

a heat exchanger operably coupled to the applicator; and

a pump having an outlet coupled to the entry port of the applicator to pump fluid into the applicator, and an inlet downstream of the heat exchanger.

9. The device of claim 1 wherein the envelope includes:

a first portion comprising a flexible first material positioned to be placed against the skin and having a first elasticity; and

a second portion sealably connected to the first portion, the second portion comprising a flexible second material facing away from the first portion and having a second elasticity less that the first elasticity, at least one of the first and second portions being movable relative to the other to accommodate the pressurized fluid therebetween.

10. The device of claim 1 wherein a portion of the envelope that is positionable against human skin has a pre-formed concave shape.

11. The cooling device of claim 1, further comprising:

a fluid driver fluidically coupled to the entry port, the exit port, and a heat exchanger, wherein the fluid driver is configured to cause fluid that has been cooled by the heat exchanger to flow through the porous internal structure to remove heat from the subcutaneous lipid-rich cells via the applicator in an amount sufficient to selectively reduce the subcutaneous lipid-rich cells.

12. The cooling device of claim 1 wherein the fluid flows through the porous internal structure to diffuse through the fluid chamber of the envelope.

13. The cooling device of claim 1 wherein the porous internal structure is physically coupled to the first internal surface and is physically coupled to the second internal surface.

14. The cooling device of claim 1 wherein the porous internal structure has a porosity of 50% or higher.

21. The cooling device of claim 1 wherein the internal structure is positioned throughout most of the fluid chamber of the envelope such that the internal structure distributes fluid flowing through the fluid chamber to promote uniform cooling of tissue adjacent the applicator.

22. The cooling device of claim 1 wherein the internal structure is positioned throughout most of the fluid chamber of the envelope when the envelope is filled with fluid.

4. A cooling device for cooling subcutaneous lipid-rich cells in a human, comprising:

an applicator releasably positionable against human skin, the applicator including;

a flexible, fluid-tight envelope having an entry port, an exit port, a fluid chamber, and first and second oppositely-facing internal surfaces positioned on opposite sides of the fluid chamber; and

a porous internal structure positioned within the envelope between the entry port and the exit port, positioned directly between the first and second internal surfaces of the envelope, and positioned throughout substantially the entire fluid chamber, the internal structure including layers of fibrous material in a face-to-face arrangement such that the layers of fibrous material slidably contact one another over substantially an entire length of the porous internal structure when the flexible, fluid-tight envelope is filled with a pressurized fluid, the porous internal structure;

(a) having a buckling strength sufficient to prevent the envelope from collapsing on itself when the outlet port is exposed to a pressure below a pressure external to the envelope, wherein the internal structure has a buckling strength sufficient to prevent the envelope from collapsing on itself when the outlet port is exposed to a pressure of up to 10 psi below a pressure external to the envelope, and

(b) being attached to an inner surface of the envelope to at least restrict the envelope from bulging when a pressurized fluid is applied to an entry port.

5. A cooling device for cooling subcutaneous lipid-rich cells in a human, comprising:

an applicator releasably positionable against human skin, the applicator including;

a flexible, fluid-tight envelope having an entry port, an exit port, and a fluid holding chamber; and

a porous internal structure positioned within the fluid holding chamber and located between the entry port and the exit port, wherein the internal structure includes multiple layers of fibrous material positioned face-to-face such that the layers of fibrous material slidably contact one another along substantially an entire length of the porous internal structure when the envelope is completely filled with a pressurized fluid, the internal structure;

(a) having a buckling strength sufficient to prevent the envelope from collapsing on itself when the outlet port is exposed to a pressure below a pressure external to the envelope, and

(b) being attached to an inner surface of the envelope to at least restrict the envelope from bulging when the pressurized fluid is applied to an entry port.

15. A cooling device for cooling subcutaneous lipid-rich cells in a human, comprising:

an applicator configured to be positioned against human skin, the applicator including;

a flexible, fluid-tight envelope having an entry port, an exit port, and first and second oppositely-facing internal surfaces; and

an internal structure contained within the envelope and positioned directly between the first and second internal surfaces, the internal structure occupying a majority of a volume of a chamber in the envelope and configured to diffuse fluid through the chamber of the envelope, the internal structure including layers of fibrous material positioned face-to-face such that the layers of fibrous material slidably contact one another along substantially an entire length of the porous internal structure when the envelope is completely filled with a pressurized fluid, the internal structure;

(a) having a sufficient buckling strength and being positioned to prevent contact between opposing inner surfaces of the envelope when the outlet port is exposed to a pressure below a pressure external to the envelope and fluid flows through the internal structure, and

(b) being attached to an inner surface of the envelope to at least restrict the envelope from bulging when fluid applied to an entry port is pressurized.

17. The cooling device of claim 15 wherein the internal structure is physically connected to the first internal surface and physically coupled to the second internal surface.

18. The cooling device of claim 15 wherein the internal structure has a porosity of 50% or higher.

19. The cooling device of claim 15 wherein the internal structure is located throughout most of a chamber of the envelope when the envelope is filled with fluid.

20. The cooling device of claim 15 wherein the internal structure extends across most of a distance between the entry port and the exit port when the envelope is filled with fluid.

16. A cooling device for cooling subcutaneous lipid-rich cells in a human, comprising:

an applicator configured to be positioned against human skin, the applicator including;

a flexible, fluid-tight envelope having an entry port, an exit port, and first and second oppositely-facing internal surfaces; and

an internal structure contained within the envelope and positioned directly between the first and second internal surfaces, the internal structure occupying a majority of a volume of a chamber in the envelope and configured to diffuse fluid through the chamber of the envelope, the internal structure;

(a) having a sufficient buckling strength and being positioned to prevent contact between opposing inner surfaces of the envelope when the outlet port is exposed to a pressure below a pressure external to the envelope and fluid flows through the internal structure, and

(b) being attached to an inner surface of the envelope to at least restrict the envelope from bulging when fluid applied to an entry port is pressurized,

a heat exchanger; and

a fluid driver fluidically coupled to the entry port, the exit port, and the heat exchanger, wherein the internal structure is porous, and wherein the fluid driver is configured to cause fluid that has been cooled by the heat exchanger to travel through the porous internal structure and to remove heat from subcutaneous lipid-rich tissue in a human via the applicator in an amount sufficient to selectively reduce the subcutaneous lipid-rich cells.

23. A cooling device for cooling subcutaneous lipid-rich cells in a human, comprising:

an applicator releasably positionable against human skin, the applicator including;

a flexible, fluid-tight envelope having an entry port, an exit port, a first surface, and a second surface; and

a porous internal structure positioned within the envelope between the entry port and the exit port and directly between the first and second surfaces, wherein the internal structure includes multiple layers of fibrous material positioned face-to-face such that the layers of fibrous material slidably contact each other along substantially an entire length of the porous internal structure when the envelope is filled with fluid, and wherein at least one of the multiple layers is slidable relative to the envelope when the envelope is filled with the fluid, the internal structure having a buckling strength sufficient to prevent the envelope from collapsing on itself when the outlet port is exposed to a pressure below a pressure external to the envelope.