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Pluripotent stem cell that induces repair and regeneration after myocardial infarction

  • US 9,844,570 B2
  • Filed: 08/15/2013
  • Issued: 12/19/2017
  • Est. Priority Date: 08/17/2012
  • Status: Active Grant
First Claim
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1. A method for treating a myocardial infarction in a subject in need thereof, the method comprising:

  • administering to said subject a cell preparation containing a cell fraction comprising a population of pluripotent stem cells positive for SSEA-3, wherein the population of pluripotent stem cells is isolated from mesenchymal tissue or cultured mesenchymal cells by selecting for SSEA-3 positive cells, wherein the population of pluripotent stem cell is concentrated, wherein the pluripotent stem cells have a plurality of properties comprising;

    (i) CD105-positivity;

    (ii) low or absent telomerase activity;

    (iii) ability to differentiate into embryonic endoderm, ectoderm, and mesoderm germ layers;

    (iv) absence of neoplastic proliferation; and

    (v) ability to self-renew, and wherein the size of the myocardial infarction in the subject is reduced in comparison to a control subject that did not receive said cell preparation, thereby treating a myocardial infarction in a subject in need thereof.

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