Nanoparticle-sized magnetic absorption enhancers having three-dimensional geometries adapted for improved diagnostics and hyperthermic treatment
First Claim
1. A method for inducing transient hyperthermia in a pathogen target, said method comprising the following steps:
- a) generating a magnetic field;
b) producing a nanoparticle-sized magnetic absorption enhancer exhibiting a controlled response to said magnetic field by;
i) providing a magnetic material having an inductive thermal response to said magnetic field;
ii) embedding said magnetic material in a coating that conforms to a predetermined shape complementary to the shape of at least one other magnetic absorption enhancer, thereby enabling a controlled mechanical response of said magnetic absorption enhancer to said magnetic field; and
iii) providing a targeting moiety for specific binding of said magnetic absorption enhancer to a pathogen target;
c) delivering said magnetic absorption enhancer to a region comprising said pathogen target for specific binding to said pathogen target;
wherein said controlled response comprises said inductive thermal response for applying a high temperature transient to said pathogen target and said controlled mechanical response comprises an interaction between said magnetic absorption enhancer and said at least one other magnetic absorption enhancer for limiting collateral damage to healthy tissue.
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Abstract
Nanoparticle-sized magnetic absorption enhancers (MAEs) exhibiting a controlled response to a magnetic field, including a controlled mechanical response and an inductive thermal response. The MAEs have a magnetic material that exhibits inductive thermal response to the magnetic field and is embedded in a coating, such that the MAE conforms to a particular shape, e.g., hemisphere, dome or shell, chosen to produce the controlled mechanical response. A targeting moiety for specifically binding the MAE to a pathogen target is also provided. The MAEs can be bound by a flexible linker to promote the desired mechanical response, which includes interactions between MAEs that are not bound to any pathogen target for the purpose of forming spheres, spherical shells, or generally spherical dimers to contain the thermal energy produced and to thus reduce collateral healthy tissue damage during hyperthermic treatment.
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Citations
18 Claims
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1. A method for inducing transient hyperthermia in a pathogen target, said method comprising the following steps:
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a) generating a magnetic field; b) producing a nanoparticle-sized magnetic absorption enhancer exhibiting a controlled response to said magnetic field by; i) providing a magnetic material having an inductive thermal response to said magnetic field; ii) embedding said magnetic material in a coating that conforms to a predetermined shape complementary to the shape of at least one other magnetic absorption enhancer, thereby enabling a controlled mechanical response of said magnetic absorption enhancer to said magnetic field; and iii) providing a targeting moiety for specific binding of said magnetic absorption enhancer to a pathogen target; c) delivering said magnetic absorption enhancer to a region comprising said pathogen target for specific binding to said pathogen target; wherein said controlled response comprises said inductive thermal response for applying a high temperature transient to said pathogen target and said controlled mechanical response comprises an interaction between said magnetic absorption enhancer and said at least one other magnetic absorption enhancer for limiting collateral damage to healthy tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification