×

SIRP polypeptide compositions and methods of use

  • US 9,845,345 B2
  • Filed: 05/17/2016
  • Issued: 12/19/2017
  • Est. Priority Date: 05/18/2015
  • Status: Active Grant
First Claim
Patent Images

1. A polypeptide comprising a SIRP-gamma polypeptide consisting of the sequence EEELQX1IQPEKLLLVTVGKTATLHCTX2TSX3X4PX5GPX6X7WFRGX8GPGRX9LIYNX10X11X12GX13FPRVTTVSDX14X15KRNNMDFSIRISSITPADVGTYYCX16KFRKGX17PEX18VEFK SGPGTEMALGAKPS (SEQ ID NO:

  • 2), wherein X1 is M, I, L or F;

    X2 is F, I, or L;

    X3 is L, I, V, H, N or D;

    X4 is F, I, L or V;

    X5 is V, I, L, P, T or A;

    X6 is V or I;

    X7 is L or Q;

    X8 is V or A;

    X9 is E or V;

    X10 is Q, P, L, V, A or E;

    X11 is K or R;

    X12 is E, D, K, N, Q or H;

    X13 is H, P or R;

    X14 is L, I, V, P, T, A, R, S or G;

    X15 is T, I, N, F, S, Y, V, A or D;

    X16 is V or I;

    X17 is S, R, N, K, T, I or M; and

    X18 is N, K, D, E, H or Q, and wherein the SIRP-gamma polypeptide binds CD47.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×