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Methods and systems for extending dynamic range in assays for the detection of molecules or particles

  • US 9,846,155 B2
  • Filed: 08/17/2015
  • Issued: 12/19/2017
  • Est. Priority Date: 03/01/2010
  • Status: Active Grant
First Claim
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1. A method for determining a measure of the concentration of analyte molecules or particles in a fluid sample, comprising:

  • providing a plurality of a first type of capture objects that each are associated with either at least one analyte molecule or particle or are free of any analyte molecules or particles;

    providing a plurality of a second type of capture objects that are free of any analyte molecules or particles, wherein the second type of capture objects are distinguishable from the first type of capture objects;

    addressing at least a portion of the first type of capture objects and determining the percentage associated with at least one analyte molecule or particle;

    addressing at least a portion of the second type of capture objects and determining at least one signal; and

    based upon the percentage, either determining a measure of the concentration of analyte molecules or particles in the fluid sample based at least in part on the percentage or particle or determining a measure of the concentration of analyte molecules or particles in the fluid sample based at least in part on the at least one signal and a measured intensity of a signal that is indicative of the presence of a plurality of analyte molecules or particles.

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