Devices for continual monitoring and introduction of gastrointestinal microbes

• US 9,848,760 B2
• Filed: 06/29/2009
• Issued: 12/26/2017
• Est. Priority Date: 06/29/2009
• Status: Expired due to Fees

• Current Assignee: Persephone Biome, Inc.
• Original Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Inventors: Bangera, Mahalaxmi Gita, Boyden, Edward S., Hyde, Roderick A., Kare, Jordin T., Leuthardt, Eric C., Rivet, Dennis J., Wood, Jr., Lowell L.
• Primary Examiner(s): NEGIN, RUSSELL SCOTT
• Application Number:
  US12/459,388
• Publication Number:
  US 20100331641A1
• Time in Patent Office: 3,102 Days
• Field of Search: None
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/42 Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence
• CPC Class Codes: G16B 20/00 ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• CPC Class Codes: G16B 20/20 Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• CPC Class Codes: G16B 5/00 ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
• CPC Class Codes: G16H 10/40 for data related to laboratory analysis, e.g. patient specimen analysis
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Systems and methods described herein include those for the continual modification of intestinal microbes. Described herein are systems including sampling devices, analysis devices, computational devices and user interface devices as well as methods for the use of such devices in combination.

Claims

1. A system for continual modification of intestinal microbes comprising:

at least one ingestible sampling device including one or more electronic detectors, the at least one ingestible sampling device including one or more physical sample collectors and an internal storage region;

at least one analysis device including a cell culture of the at least one sample;

at least one computational device operably connected to the at least one analysis device, and including in memory a standard profile for gastrointestinal microbes;

at least one user interface device operably connected to the at least one computational device, the user interface device including a monitor; and

at least one material dispensing device connected to the at least one computational device.

2. The system of claim 1, wherein the at least one sampling device comprises:

one or more chemical sensors.

3. The system of claim 1, wherein the at least one sampling device comprises:

one or more containers.

4. The system of claim 1, wherein the at least one sampling device comprises:

one or more absorbent pads.

5. The system of claim 1, wherein the at least one sampling device comprises:

at least one additional ingestible sampling device.

6. The system of claim 1, wherein the at least one analysis device comprises:

at least one nucleic acid analysis device.

7. The system of claim 1, wherein the at least one analysis device comprises:

at least one protein analysis device.

8. The system of claim 1, wherein the at least one analysis device comprises:

at least one chemical analysis device.

9. The system of claim 1, wherein the at least one analysis device comprises:

at least one electronic detectors.

10. The system of claim 1, wherein the at least one computational device and the at least one user interface device are an integrated unit.

11. The system of claim 1, comprising:

at least one additional sampling device.

12. The system of claim 1, comprising:

at least one dietary sampling device.

13. The system of claim 12, wherein the at least one dietary sampling device is operably connected to the at least one computational device.

14. A system for monitoring and introducing gastrointestinal microbes into a mammalian gastrointestinal tract over time, comprising:

at least one gastrointestinal microbe analysis device;

at least one computational device connected to the at least one gastrointestinal microbe analysis device, the at least one computational device including logic with protocols to integrate information relating to an individual with information from the at least one gastrointestinal microbe analysis device;

at least one user interface connected to the at least one computational device; and

at least one material dispensing device connected to the at least one computational device, the at least one material dispensing device including control circuitry for the at least one material dispensing device and at least one data storage unit including dispensation protocols.

15. The system of claim 14, wherein the at least one gastrointestinal microbe analysis device is configured to be reusable.

16. The system of claim 14, wherein the at least one gastrointestinal microbe analysis device comprises:

at least one nucleic acid analysis device.

17. The system of claim 14, wherein the at least one gastrointestinal microbe analysis device comprises:

at least one protein analysis device.

18. The system of claim 14, wherein the at least one gastrointestinal microbe analysis device comprises:

at least one chemical analysis device.

19. The system of claim 14, wherein the at least one gastrointestinal microbe analysis device includes an electronic detector.

20. The system of claim 14, wherein the at least one computational device is connected to the at least one gastrointestinal microbe analysis device.

21. The system of claim 14, wherein the at least one material dispensing device is configured to dispense at least one microbe, antibiotic, antifungal, prebiotic, or probiotic agent.

22. The system of claim 14, comprising:

at least one additional gastrointestinal microbe analysis device.

23. The system of claim 14, comprising:

at least one dietary sampling device.

24. The system of claim 23, wherein the at least one dietary sampling device is operably connected to the at least one computational device.