Methods and devices for endovascular embolization

• US 9,848,883 B2
• Filed: 10/17/2014
• Issued: 12/26/2017
• Est. Priority Date: 07/31/2013
• Status: Active Grant

• Current Assignee: Embolic Acceleration, LLC
• Original Assignee: EMBA Medical Limited
• Inventors: Cragg, Andrew H., Logan, John, Naglreiter, Brett E., Arp, Scott R., Espinosa, Alejandro, Green, Nicholas A., Gamez, Victor M.
• Primary Examiner(s): Anderson, Gregory
• Assistant Examiner(s): LAUER, CHRISTINA C
• Application Number:
  US14/517,740
• Publication Number:
  US 20150039019A1
• Time in Patent Office: 1,166 Days
• CPC Class Codes: A61B 17/12031 complete occlusion
• CPC Class Codes: A61B 17/12036 partial occlusion
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12168 having a mesh structure A61B17/1214 takes precedence
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12177 comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/00778 Operations on blood vessels A61B2017/22097, A61B2017/320741 take precedence
• CPC Class Codes: A61B 2017/00995 having a thin film
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2017/12054 Details concerning the detachment of the occluding device from the introduction device
• CPC Class Codes: A61B 2017/22082 after introduction of a substance
• CPC Class Codes: A61F 2/01 Filters implantable into blood vessels
• CPC Class Codes: A61F 2002/018 made from tubes or sheets of material, e.g. by etching or laser-cutting

Abstract

The present disclosure describes an occlusion device and methods of delivering the occlusion device. The occlusion device can include an expandable structure configured to move between an unexpanded configuration and an expanded configuration. The expandable structure can be configured to have an expansion ratio of at least about 5:1. Further, the occlusion device can be configured to prevent substantially all fluid from flowing past the occlusion device when the occlusion device is in the expanded configuration in the vessel.

Claims

1. A method of occluding a vessel, comprising the steps of:

advancing an occlusion device over a guidewire, the occlusion device comprising a collapsible tube having a guidewire lumen;

deploying an anchoring lobe of the occlusion device in a vessel, without total vessel occlusion;

thereafter deploying an occlusion lobe of the device in the vessel to occlude blood flow;

wherein the anchoring lobe is separated from the occlusion lobe by a hub, the anchoring lobe being downstream of the occlusion lobe; and

retracting the guidewire to allow the collapsible tube to collapse in the occlusion lobe in response to blood pressure, the collapsed tube extending from the hub and into the occlusion lobe.

2. A method of occluding a vessel as in claim 1, additionally comprising evaluating the position of the occlusion device in the vessel prior to the deploying an occlusion lobe step.

3. A method of occluding a vessel as in claim 1, wherein the anchoring lobe comprises a concave configuration, concave in a direction facing away from the occlusion lobe.

4. A method of occluding a vessel as in claim 3, wherein the occlusion lobe comprises a plurality of side wall struts.

5. A method of occluding a vessel as in claim 4, wherein the side wall struts carry a membrane.

6. A method of occluding a vessel as in claim 1, wherein the anchoring lobe comprises a plurality of side wall struts.

7. A method of occluding a vessel as in claim 1, wherein following deployment in an artery with the occlusion lobe in an anatomically proximal orientation, blood pressure on a concave side of the occlusion lobe generates a radially outward force from the occlusion lobe against the artery wall.

8. A method of occluding a vessel as in claim 7, wherein blood pressure on the concave side of the occlusion lobe generates an axially distal force on the occlusion device.

9. A method of occluding a vessel as in claim 1, wherein the occlusion device has an expansion ratio of at least about 6:

1.

10. A method of occluding a vessel as in claim 9, wherein the occlusion device has an expansion ratio of at least about 7:

1.

11. A method of occluding a vessel as in claim 1, wherein the deploying an occlusion lobe step comprises deploying an occlusion lobe having an unconstrained expanded diameter of at least about 6.0 mm, from a lumen having a 1 mm or smaller inside diameter lumen.

12. A method of occluding a vessel as in claim 1, wherein the device is configured to occlude at least about 90 percent of flow through a vessel following the deploying an occlusion lobe step.

13. A method of occluding a vessel as in claim 12, wherein the device is configured to achieve a reduction in blood flow of at least about 80% within 2 minutes following the deploying an occlusion lobe step.

14. A method of occluding a vessel as in claim 13, wherein the device is configured to achieve a reduction in blood flow of at least about 80% within 1 minute following the deploying an occlusion lobe step.

15. A method of occluding a vessel as in claim 1, wherein the device configured to achieve total occlusion within 5 minutes following the deploying an occlusion lobe step.

16. A method of occluding a vessel as in claim 15, wherein the device is configured to achieve total occlusion within 1 minute following the deploying an occlusion lobe step.