Thermochemical ablation of bodily tissue

• US 9,848,934 B2
• Filed: 01/05/2015
• Issued: 12/26/2017
• Est. Priority Date: 02/27/2007
• Status: Active Grant

• Current Assignee: Regents of The University of Minnesota (University of Minnesota)
• Original Assignee: Regents of The University of Minnesota (University of Minnesota)
• Inventors: Cressman, Erik N.K.
• Primary Examiner(s): Stigell, Theodore
• Application Number:
  US14/589,211
• Publication Number:
  US 20150173821A1
• Time in Patent Office: 1,086 Days
• CPC Class Codes: A61B 18/06 caused by chemical reaction , e.g. moxaburners
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/068 none of the reactants being oxygen

Abstract

Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.

Claims

1. A thermochemical ablation system, comprising:

a percutaneous fluid delivery cannula comprising first and second lumens extending from a proximal portion to a distal portion, the distal portion comprising a first exterior port along a distal exterior portion of the percutaneous fluid delivery cannula and a second exterior port along the distal exterior portion of the percutaneous fluid delivery cannula, the first exterior port being in fluid communication with the first lumen, and the second exterior port in fluid communication with the second lumen;

first means for containing a first thermochemical ablation liquid and communicating the first thermochemical ablation liquid through the first lumen to the first exterior port along the distal exterior portion of the percutaneous fluid delivery cannula; and

second means for containing a second thermochemical ablation liquid and communicating the second thermochemical ablation liquid through the second lumen to the second exterior port along the distal exterior portion of the percutaneous fluid delivery cannula so that the second thermochemical ablation liquid is isolated from the first thermochemical ablation liquid before exiting from the second exterior port of the percutaneous fluid delivery cannula, the second thermochemical ablation liquid being reactive with the first thermochemical ablation liquid,

means for simultaneously delivering the first and second thermochemical ablation liquids out of the respective first and second exterior ports along the distal exterior portion of the percutaneous fluid delivery cannula to provide simultaneous dispersion and mixing of the first and second thermochemical ablation liquids proximate to the distal exterior portion, the second thermochemical ablation liquid being reactive with the first thermochemical ablation liquid to generate tissue ablation heat via an exothermic chemical reaction.

2. The system of claim 1, wherein the means for simultaneous delivery comprises:

a first actuator to deliver liquid from the first means for containing, and a second actuator to deliver liquid from the second means for containing, the first and second actuators being coupled to one another so as to provide simultaneous actuation.

3. The system of claim 1, wherein the first thermochemical ablation liquid comprises an acid contained in the first means for containing.

4. The system of claim 3, wherein the first thermochemical ablation liquid comprises an acid selected from the group consisting of acetic acid, peracetic acid, hydrochloric acid, hydrobromic acid, hydriodic acid, sulfuric acid, nitric acid, nitrous acid, perchloric acid, phosphoric acid, oxalic acid, pyruvic acid, malonic acid, and amino acids.

5. The system of claim 3, wherein the second thermochemical ablation liquid comprises a base contained in the first means for containing.

6. The system of claim 5, wherein the second thermochemical ablation liquid comprises base selected from the group consisting of KOH, NaOH, NH₄OH, Ca(OH)₂, NaHCO₃, K₂CO₂, BuLi, NaOEt or NaSEt, NaH, KH, and amines.

7. The system of claim 1, wherein the first thermochemical ablation liquid comprises an electrophile selected from the group consisting of acetic anhydride, acetyl chloride, and acetyl bromide, and the second thermochemical ablation liquid comprises a nucleophile.

8. The system of claim 1, wherein the percutaneous fluid delivery cannula comprises a generally rigid injection needle.

9. The system of claim 8, wherein the injection needle comprises an outside diameter of about 0.134 inches or less.

10. The system of claim 1, wherein the percutaneous fluid delivery cannula comprises a flexible catheter.