Implant and method for manufacturing same

• US 9,849,005 B2
• Filed: 04/08/2013
• Issued: 12/26/2017
• Est. Priority Date: 04/16/2012
• Status: Active Grant

• Current Assignee: Biotronik AG (Biotronik SE & Company KG)
• Original Assignee: Biotronik AG (Biotronik SE & Company KG)
• Inventors: Schmiedl, Robert, Gratz, Matthias, Schaldach, Max, Lang, Volker
• Primary Examiner(s): Woznicki, Jacqueline
• Application Number:
  US13/858,696
• Publication Number:
  US 20130274869A1
• Time in Patent Office: 1,723 Days
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body

Abstract

A method for manufacturing an implant and an implant, in particular an intraluminal endoprosthesis, including a body having a coating on at least a portion of the surface thereof, and the degradation of which can be influenced from the outside in a targeted manner, the method having the following steps:

• a) providing an implant body, and
• b) applying a coating to the surface of the implant body, wherein the coating comprises unfilled cavities, preferably in the form of microbubbles (2).

Claims

1. A method for manufacturing a biodegradable implant comprising the following steps:

a) providing an implant body;

b) applying a pharmaceutical layer to the implant body, wherein the pharmaceutical layer comprises a pharmaceutically active substance; and

c) applying a coating comprising rupturable, unfilled microbubbles over the pharmaceutical layer, wherein the microbubbles are configured to rupture by way of ultrasonic excitation.

2. The method according to claim 1, wherein the microbubbles are formed of polylactic acid (PLA) and the pharmaceutically active substance is hyaluronic acid.

3. A biodegradable implant comprising a body at least partially coated with a pharmaceutical layer and over the pharmaceutical layer is a coating of microbubbles filled with inert gas and configured to rupture by way of ultrasonic excitation.

4. The implant according to claim 3, characterized in that the implant body comprises struts, wherein a luminal side of the struts comprises recesses coated with the microbubbles.

6. The implant according to claim 3, wherein the gas comprises molecules sized to prevent diffusion of the molecules through shells of the microbubbles.

7. The implant according to claim 3, wherein the gas comprises perfluorocarbons or sulphur tetrafluoride.

5. A biodegradable implant comprising a body at least partially coated with a pharmaceutical layer coated with microbubbles filled with inert gas and configured to rupture by way of ultrasonic excitation, characterized in that the microbubbles are attached to a surface of the implant body using an embedding matrix, wherein the matrix comprises at least one material selected from the group consisting of a polymer, a lipid, a citrate-based softening agent, a protein and a peptide.