Methods and products for tissue repair

• US 9,849,213 B2
• Filed: 03/28/2016
• Issued: 12/26/2017
• Est. Priority Date: 09/28/2006
• Status: Active Grant

• Current Assignee: Children's Medical Center Corporation
• Original Assignee: Children's Medical Center Corporation
• Inventors: Murray, Martha M.
• Primary Examiner(s): GUDIBANDE, SATYANARAYAN R
• Application Number:
  US15/082,235
• Publication Number:
  US 20160206779A1
• Time in Patent Office: 638 Days
• Field of Search: None
• CPC Class Codes: A61F 2/0811 Fixation devices for tendons or ligaments
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/401 Proline; Derivatives thereof, e.g. captopril
• CPC Class Codes: A61K 35/17 Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes when activated by a specific antigen A61K39/00
• CPC Class Codes: A61K 35/19 Platelets; Megacaryocytes
• CPC Class Codes: A61K 38/39 Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61L 2300/252 Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/432 Inhibitors, antagonists A61L2300/402 - A61L2300/43 take precedence
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 2300/64 Animal cells
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 2430/10 for reconstruction of tendons or ligaments
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/3616 Blood, e.g. platelet-rich plasma
• CPC Class Codes: A61L 27/3662 Ligaments, tendons
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 : Materials at least partially resorbable by the body
• CPC Class Codes: A61P 19/02 : for joint disorders, e.g. arthritis, arthrosis

Abstract

Methods and devices for the repair of articular tissue using collagen material are provided. Compositions of collagen material and related kits are also provided.

Claims

1. A composition comprising

a sterile solution of solubilized collagen in a concentration of greater than 5 and less than or equal to 50 mg/ml and having a viscosity of 1,000-200,000 centipoise, a buffer wherein the composition has an osmolarity of 280-350 mOs/kg, wherein the composition is free of crosslinking agent.

2. The composition of claim 1, wherein the solution is a liquid or gel.

3. The composition of claim 1, wherein the solubilized collagen is present in a concentration of greater than 15 mg/ml and less than or equal to 40 mg/ml.

4. The composition of claim 1, further comprising a platelet, white blood cells, an antibiotic, an anti-plasmin agent, insoluble collagen, a plasminogen activator inhibitor, a glycosaminoglycan, decorin or biglycan.

5. The composition of claim 1, wherein the composition has a pH of 6.8-8.0.

6. The composition of claim 1, wherein the collagen is enzyme solubilized collagen or atelocollagen.

7. The composition of claim 1, wherein the solution is maintained at a temperature of 4°

C.

8. A quick set composition comprising

a sterile solution of solubilized collagen in a concentration of greater than 5 and less than or equal to 50 mg/ml and having a viscosity of 1,000-200,000 centipoises and a pH of 6.8-8.0, wherein the solution has an osmolarity of 280-350 mOs/kg, wherein the solution sets into a scaffold within 10 minutes of exposure to temperatures of greater than 30°

C.

9. A compressible expandable scaffold, comprising a collagen sponge, wherein the collagen is type I soluble collagen and collagen is in a concentration of grater than 5 and less than or equal to 50 mg/ml, wherein the collagen sponge is free of crosslinking agent.