Systems and methods for delivering a medicament

• US 9,849,216 B2
• Filed: 03/02/2007
• Issued: 12/26/2017
• Est. Priority Date: 03/03/2006
• Status: Active Grant

• Current Assignee: Smith & Nephew Incorporated (Smith & Nephew PLC)
• Original Assignee: Smith & Nephew Incorporated (Smith & Nephew PLC)
• Inventors: Austin, Gene Edward, Janna, Sied W., Rains, James K., Rose, John, Whitehurst, Lee
• Primary Examiner(s): GRAY, PHILLIP A
• Application Number:
  US12/281,495
• Publication Number:
  US 20100094195A1
• Time in Patent Office: 3,952 Days
• Field of Search: 604 20- 22, 604501, 6048901-8921, 604131
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61L 2300/608 having two or more layers
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence

Abstract

A medicament containment device (106) is provided containing a medicament (114) and is associated with an implant, such as an orthopedic implant (102). The medicament containment device (106) can degrade upon exposure to energy, such as energy (112) from an energy source (110). The orthopedic implant (102), including the medicament containment device is implanted or inserted into an environment (100) such as a patient'"'"'s body. The energy source (110) can be used outside the patient'"'"'s body, but in proximity to the orthopedic implant (102), to apply energy (112) to the medicament containment device (106). Upon exposure to the energy (112), the medicament containment device (106) can degrade and release the medicament (114) into the environment (100). The medicament (114) can kill and/or disrupt bacterial cells (108) or other infectious cells that form in proximity to the orthopedic implant (102).

Claims

1. A medicament containment device for association with an orthopaedic implant, the medicament containment device comprising:

a first medicament;

a second medicament; and

a first layer substantially surrounding a second layer, the first medicament being disposed between the first layer and the second layer, and the second layer substantially surrounding the second medicament;

wherein the medicament containment device is attached to or embedded in the orthopaedic implant;

wherein the first layer is configured to at least partially degrade and release at least part of the first medicament in response to ultrasound energy from an energy source, the first layer at least partially exposing the second layer to an environment after the first layer at least partially degrades; and

wherein the second layer is configured to at least partially degrade over time in response to exposure to the environment and release at least part of the second medicament over time in response to exposure to the environment after the first layer at least partially degrades.

2. The medicament containment device of claim 1, wherein the first layer has a first resonant frequency and is configured to degrade in response to energy at the first resonant frequency, and wherein the second layer has a second resonant frequency and is configured to degrade in response to energy at the second resonant frequency, the second resonant frequency being different from the first resonant frequency.

3. The medicament containment device of claim 1, wherein the orthopaedic implant is a resorbable orthopaedic implant configured to degrade over a period of time and the medicament is a resorbtion acceleration agent;

and

wherein the resorbtion acceleration agent is configured to increase the rate of degradation by the resorbable orthopaedic implant.

4. The medicament containment device of claim 1, wherein the energy is at least one of an ultrasound wave, thermal, light wave, radar, sonar, ultraviolet light wave, microwave, electrical, magnetic field, vibratory, and laser.

5. The medicament containment device of claim 1, wherein the first medicament or the second medicament comprises an antibiotic.

6. The medicament containment device of claim 1, wherein the first medicament or the second medicament comprises an osteogenic factor.

7. The medicament containment device of claim 1, wherein the first medicament or the second medicament comprises an osteoblast affecting agent or an osteoclast affecting agent.

8. A medicament containment device for association with an orthopaedic implant, the medicament containment device comprising:

a medicament; and

a first layer substantially surrounding a second layer, the second layer substantially surrounding the medicament;

wherein the medicament containment device is attached to or embedded in the orthopaedic implant, the orthopaedic implant comprising a bone fixation structure;

wherein the first layer is configured to at least partially degrade when the first layer is exposed to energy from an energy source;

wherein the second layer is configured to at least partially degrade and release at least part of the medicament after the first layer degrades;

wherein the orthopaedic implant is a resorbable orthopaedic implant configured to degrade over a period of time and the medicament is a resorbtion acceleration agent; and

wherein the resorbtion acceleration agent is configured to increase the rate of degradation by the resorbable orthopaedic implant.

9. The medicament containment device of claim 8, wherein the first layer at least partially exposes the second layer to an environment;

and wherein the second layer is a resorbable layer and is configured to at least partially degrade after exposure to the environment.

10. The medicament containment device of claim 8, wherein the first layer has a first resonant frequency and is configured to degrade in response to energy at the first resonant frequency, and wherein the second layer has a second resonant frequency and is configured to degrade in response to energy at the second resonant frequency, the second resonant frequency being different from the first resonant frequency.

11. The medicament containment device of claim 8, wherein the energy is at least one of an ultrasound wave, thermal, light wave, radar, sonar, ultraviolet light wave, microwave, electrical, magnetic field, vibratory, and laser.

19. The medicament containing device of claim 8, wherein the resorbable orthopaedic implant is an internal bone fixation device comprising a plate,

wherein the medicament containing device is attached to or embedded in the plate, and

wherein the medicament containing device is arranged on the plate to release the resorbtion acceleration agent to increase the rate of degradation of the plate.

20. The medicament containing device of claim 8, wherein the resorbable orthopaedic implant is an internal bone fixation device comprising an intramedullary nail,

wherein the medicament containing device is attached to or embedded in the intramedullary nail, and

wherein of the medicament containing device is arranged on the intramedullary nail to release the resorbtion acceleration agent to increase the rate of degradation of the intramedullary nail.

12. A medicament containment device for association with an orthopaedic implant, the medicament containment device comprising:

a medicament; and

a first layer substantially surrounding a second layer, the second layer substantially surrounding the medicament;

wherein the medicament containment device is attached to or embedded in the orthopaedic implant;

wherein the first layer is configured to at least partially degrade when the first layer is exposed to ultrasound energy at a first frequency, wherein ultrasound energy at the first frequency does not cause degradation of the second layer sufficient to release the medicament; and

wherein the second layer is configured to at least partially degrade and release at least part of the medicament in response to ultrasound energy at a second frequency after the first layer at least partially degrades, the second frequency being different from the first frequency.

13. The medicament containment device of claim 12, wherein the first layer at least partially exposes the second layer to an environment;

and wherein the second layer is a resorbable layer and is configured to at least partially degrade after exposure to the environment.

14. The medicament containment device of claim 12, further comprising:

a first medicament between the first layer and the second layer, wherein the medicament substantially surrounded by the second layer is a second medicament.

15. The medicament containment device of claim 12, wherein the orthopaedic implant is a resorbable orthopaedic implant configured to degrade over a period of time and the medicament is a resorbtion acceleration agent;

and

wherein the resorbtion acceleration agent is configured to increase the rate of degradation by the resorbable orthopaedic implant.

16. The medicament containment device of claim 14, wherein the first medicament or the second medicament comprises an antibiotic.

17. The medicament containment device of claim 14, wherein the first medicament or the second medicament comprises an osteogenic factor.

18. The medicament containment device of claim 14, wherein the first medicament or the second medicament comprises an osteoblast affecting agent or an osteoclast affecting agent.

21. The medicament containing device of claim 12, wherein the medicament is a first medicament, and

wherein the medicament containing device further comprises a second medicament disposed between the first layer and the second layer, the first layer being configured to release the first medicament after the first layer at least partially degrades in response to exposure to ultrasound energy at the first frequency.