Drug-delivery pump with intelligent control
First Claim
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1. A drug pump device comprising:
- a drug reservoir containing a fluid;
an exit member for fluidically connecting the reservoir with a drug injection site;
a sensor;
an electrolysis pump comprising a pump chamber in mechanical communication with the drug reservoir via an intervening displacement member, the electrolysis pump being operable to exert a pressure to drive the intervening displacement member toward the exit member and thereby force therethrough the fluid in the drug reservoir; and
control circuitry for (i) storing one or more delivery parameters and target values therefor, (ii) operating the electrolysis pump in a priming stage to force a volume of the fluid from the drug reservoir into the exit member but substantially before any delivery of fluid from the exit member, (iii) based on signals received from the sensor during the priming stage before substantially any delivery of fluid from the exit member, determining a deviation between a target value of one or more delivery parameters and a measured value thereof for delivery of a target volume of fluid, and (iv) based at least in part on the determined deviation, operating the pump in a delivery stage to force the target volume of fluid from the drug reservoir out through the exit member.
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Abstract
Embodiments of the present invention utilize a closed-loop feedback control system to ensure accurate drug delivery. This control system may, for example, utilize a flow sensor to measure the volume of delivery and an intelligent control algorithm to anticipate and compensate for overdoses and underdoses. Feedback control systems in accordance herewith can be applied to any piston- or plunger-driven pump system utilizing sensors that measure flow directly or indirectly. In some embodiments, adjustments are made during a “priming” stage when liquid is pumped through the internal fluid path but does not exit the pump.
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Citations
19 Claims
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1. A drug pump device comprising:
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a drug reservoir containing a fluid; an exit member for fluidically connecting the reservoir with a drug injection site; a sensor; an electrolysis pump comprising a pump chamber in mechanical communication with the drug reservoir via an intervening displacement member, the electrolysis pump being operable to exert a pressure to drive the intervening displacement member toward the exit member and thereby force therethrough the fluid in the drug reservoir; and control circuitry for (i) storing one or more delivery parameters and target values therefor, (ii) operating the electrolysis pump in a priming stage to force a volume of the fluid from the drug reservoir into the exit member but substantially before any delivery of fluid from the exit member, (iii) based on signals received from the sensor during the priming stage before substantially any delivery of fluid from the exit member, determining a deviation between a target value of one or more delivery parameters and a measured value thereof for delivery of a target volume of fluid, and (iv) based at least in part on the determined deviation, operating the pump in a delivery stage to force the target volume of fluid from the drug reservoir out through the exit member. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of controlling an actual delivery volume of fluid in a drug pump device comprising a drug reservoir containing a fluid, an exit member for fluidically connecting the reservoir with a drug injection site, and an electrolysis pump operable to exert a pressure to drive the displacement member toward the exit member and thereby force therethrough the fluid in the drug reservoir to conform to a target delivery volume, the method comprising:
- operating the electrolysis pump in a priming stage to force a volume of the fluid from the drug reservoir into the exit member but substantially before any delivery of fluid from the exit member;
during the priming stage before substantially any delivery of fluid from the exit member, receiving signals from a sensor and, based thereon, determining a deviation between an expected value of one or more delivery parameters and a measured value thereof for delivery of the target delivery volume; and
based at least in part on the determined deviation, operating the pump in a delivery stage to force the target delivery volume of fluid from the drug reservoir out through the exit member. - View Dependent Claims (14, 15, 16, 17, 18, 19)
- operating the electrolysis pump in a priming stage to force a volume of the fluid from the drug reservoir into the exit member but substantially before any delivery of fluid from the exit member;
Specification