Method of operating a control device for controlling an infusion device
First Claim
1. A method of operating a control device for controlling an infusion device for administering a drug to a patient, the method comprising the steps of:
- (a) providing a model to predict a time-dependent drug concentration in multiple compartments of a patient;
(b) setting a target concentration value to be achieved in at least one of the compartments of the patient;
(c) determining a drug dosage to be administered to a first compartment of the multiple compartments of the patient using the model such that the difference between the target concentration value and a predicted steady-state drug concentration in the at least one of the compartments is smaller than a pre-defined threshold value;
(d) providing a control signal indicative of the drug dosage to an infusion device for administering the drug dosage to the patient;
(e) obtaining at least one measurement value indicating a measured drug concentration in at least a second compartment of the multiple compartments at one or more measurement times;
(f) adjusting the model such that the model predicts a drug concentration in at least the second compartment at one or more measurement times, which at least approximately matches the measured drug concentration in at least said second compartment; and
(g) determining a new drug dosage to be administered into the first compartment of the patient using the model such that the difference between the target concentration value and a predicted steady-state drug concentration in the at least one of the compartments is smaller than the pre-defined threshold value.
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Abstract
Method of operating a control device for controlling an infusion device A method of operating a control device (2) for controlling an infusion device (33) for administering a drug to a patient (P) comprises the steps of: providing a model (p) to predict a time-dependent drug concentration (Cplasma, Clung, Cbrain) in multiple compartments (A1-A5) of a patient (P); setting a target concentration value (CTbrain) to be achieved in at least one of the compartments (A1-A5) of the patient (P); determining a drug dosage (D1) to be administered to a first compartment (A1) of the multiple compartments (A1-A5) of the patient (P) using the model (p) such that the difference between the target concentration value (CTbrain) and a predicted steady-state drug concentration (Cplasma, Clung, Cbrain) in the at least one of the compartments (A1-A5) is smaller than a pre-defined threshold value (Ub-rain); providing a control signal (S1) indicative of the drug dosage (D1) to an infusion device (33) for administering the drug dosage (D1) to the patient (P); obtaining a measurement value (M1, M2) indicating a measured drug concentration in a second compartment (A2, A3) of the multiple compartments (A1-A5) at a measurement time (t1, t2); adjusting the model (p) such that the model (p) predicts a drug concentration (Clung, Cbrain) in the second compartment (A2, A3) at the measurement time (t1, t2) which at least approximately matches the measured drug concentration in the second compartment (A2, A3); and determining a new drug dosage (D2, D3) to be administered into the first compartment (A1) of the patient (P) using the model (p) such that the difference between the target concentration value (CT-brain) and a predicted steady-state drug concentration (Cplasma, Clung, Cbrain) in the at least one of the compartments (A1, A2, A3) is smaller than the predefined threshold value (Ubrain). In this way a method is provided which allows for an improved (personalized and predictive) control of a drug administration procedure, in particular when administering an anaesthetic drug such as Propofol and/or an analgesic drug such as Remifentanil within a procedure.
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Citations
16 Claims
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1. A method of operating a control device for controlling an infusion device for administering a drug to a patient, the method comprising the steps of:
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(a) providing a model to predict a time-dependent drug concentration in multiple compartments of a patient; (b) setting a target concentration value to be achieved in at least one of the compartments of the patient; (c) determining a drug dosage to be administered to a first compartment of the multiple compartments of the patient using the model such that the difference between the target concentration value and a predicted steady-state drug concentration in the at least one of the compartments is smaller than a pre-defined threshold value; (d) providing a control signal indicative of the drug dosage to an infusion device for administering the drug dosage to the patient; (e) obtaining at least one measurement value indicating a measured drug concentration in at least a second compartment of the multiple compartments at one or more measurement times; (f) adjusting the model such that the model predicts a drug concentration in at least the second compartment at one or more measurement times, which at least approximately matches the measured drug concentration in at least said second compartment; and (g) determining a new drug dosage to be administered into the first compartment of the patient using the model such that the difference between the target concentration value and a predicted steady-state drug concentration in the at least one of the compartments is smaller than the pre-defined threshold value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A control device for controlling an infusion device for administering a drug to a patient, the control device being constituted to:
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(a) provide a model to predict a time-dependent drug concentration in multiple compartments of a patient; (b) set a target concentration value to be achieved in at least one of the compartments of the patient; (c) determine a drug dosage to be administered to a first compartment of the multiple compartments of the patient using the model such that the difference between the target concentration value and a predicted steady-state drug concentration in the at least one of the compartments is smaller than a pre-defined threshold value; (d) provide, as an output, a control signal indicative of the drug dosage to an infusion device for administering the drug dosage to the patient; (e) obtain, as an input, at least one measurement value indicating a measured drug concentration in a least a second compartment of the multiple compartments at a measurement time; (f) adjust the model such that the model predicts a drug concentration in at least the second compartment at the one or more measurement time which at least approximately matches the measured drug concentration in at least the second compartment; and (g) determine a new drug dosage to be administered into the first compartment of the patient using the model such that the difference between the target concentration value and a predicted steady-state drug concentration in the at least one of the compartments is smaller than the pre-defined threshold value. - View Dependent Claims (16)
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Specification