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Method of operating a control device for controlling an infusion device

  • US 9,849,241 B2
  • Filed: 02/24/2014
  • Issued: 12/26/2017
  • Est. Priority Date: 04/24/2013
  • Status: Active Grant
First Claim
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1. A method of operating a control device for controlling an infusion device for administering a drug to a patient, the method comprising the steps of:

  • (a) providing a model to predict a time-dependent drug concentration in multiple compartments of a patient;

    (b) setting a target concentration value to be achieved in at least one of the compartments of the patient;

    (c) determining a drug dosage to be administered to a first compartment of the multiple compartments of the patient using the model such that the difference between the target concentration value and a predicted steady-state drug concentration in the at least one of the compartments is smaller than a pre-defined threshold value;

    (d) providing a control signal indicative of the drug dosage to an infusion device for administering the drug dosage to the patient;

    (e) obtaining at least one measurement value indicating a measured drug concentration in at least a second compartment of the multiple compartments at one or more measurement times;

    (f) adjusting the model such that the model predicts a drug concentration in at least the second compartment at one or more measurement times, which at least approximately matches the measured drug concentration in at least said second compartment; and

    (g) determining a new drug dosage to be administered into the first compartment of the patient using the model such that the difference between the target concentration value and a predicted steady-state drug concentration in the at least one of the compartments is smaller than the pre-defined threshold value.

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