Foldable adhesive composite dressing

• US 9,849,270 B2
• Filed: 12/12/2012
• Issued: 12/26/2017
• Est. Priority Date: 12/16/2011
• Status: Active Grant

• Current Assignee: Kindeva Drug Delivery L.P.
• Original Assignee: 3M Innovative Properties Company (3M Company)
• Inventors: Stockholm, Andrew J.
• Primary Examiner(s): FLICK, JASON E
• Application Number:
  US14/364,707
• Publication Number:
  US 20140303594A1
• Time in Patent Office: 1,840 Days
• Field of Search: 604506
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61B 18/14 Probes or electrodes therefor
• CPC Class Codes: A61B 2018/0047 Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61K 9/0021 Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61K 9/703 characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/0061 Methods for using microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: Y10T 156/10 Methods of surface bonding and/or assembly therefor

Abstract

An adhesive composite dressing useful for applying an active ingredient to a treated skin site, as well as methods of manufacture and use of such dressings. In one embodiment, an adhesive composite dressing comprising an anchor member, a target member, and a folding member, where the anchor member comprises a first skin-contact adhesive, the target member comprises an opening adapted to enable skin treatment, the folding member comprises a drug reservoir, and where the folding member is attached to the anchor portion through a hinge defined by a line of attachment that is not contiguous with an edge of the anchor member.

Claims

1. An adhesive composite dressing comprising:

an anchor member comprising a first skin-contact adhesive;

a target member comprising an opening adapted to enable skin treatment;

a folding member comprising a drug reservoir and a second skin-contact adhesive, wherein the folding member is attached to the anchor member through a hinge defined by a line of attachment that is not contiguous with an edge of the anchor member; and

an impermeable barrier between the drug reservoir and the second skin-contact adhesive.

2. The adhesive composite dressing of claim 1 wherein the folding member is attached to the anchor member by an adhesive layer.

3. The adhesive composite dressing of claim 1 further comprising a support layer releasably attached to the folding member on a side opposed to the second skin-contact adhesive.

4. The adhesive composite dressing of claim 1 wherein the drug reservoir and the target member opening are positioned opposed to each other and equidistant from the hinge so that the drug reservoir may come into alignment with a treated area of skin when the folding member is folded so as to be adjacent to the treated area of skin.

5. An adhesive composite dressing of claim 1, wherein the adhesive composite dressing is adapted to be connected to a skin treatment device.

6. The adhesive composite dressing of claim 5 wherein the dressing is adapted to be releasably connected to the skin treatment device by an adhesive, mechanically, or by magnetic force.

7. The adhesive composite dressing of claim 1 wherein the drug reservoir comprises a drug selected from the group consisting of proteins, peptides, nucleotide sequences, monoclonal antibodies, vaccines, polysaccharides, and antibiotics.

8. The adhesive composite dressing of claim 1 wherein the dressing is provided within a hermetically sealed pouch.

9. A kit comprising:

an adhesive composite dressing of claim 1; and

a skin treatment device.

10. The kit of claim 9 wherein the adhesive composite dressing is releasably attached to the skin treatment device.

11. A method of applying a drug reservoir to a treated area of skin with a patch comprising an anchor member, a target member, and a folding member, the folding member comprising the drug reservoir and being attached to the anchor portion through a hinge defined by a line of attachment that is not contiguous with an edge of the anchor member, the target member comprising an opening adapted to enable skin treatment, the method comprising:

attaching the anchor member of the patch to a non-treated area of skin,

treating the area of skin left exposed by the target opening with a treatment method that increases the permeability of the skin,

rotating the folding member around the hinge so that at least a portion of the folding member adheres to the skin and so that the drug reservoir contacts the treated area of skin and

removing the anchor member from the skin while leaving the drug reservoir in contact with the treated area of skin.

12. The method of claim 11 wherein the skin is treated with a skin treatment device selected from the group consisting of an RF ablation device, a heat ablation device, and a microneedle array.

13. The method of claim 11 wherein the increased permeability of the skin is with respect to pharmaceutically active agents.

14. The method of claim 11 wherein the treatment method forms a plurality of pores in the skin.