Method and/or system for multicompartment analyte monitoring
First Claim
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1. A method comprising:
- estimating, using a controller of a glucose control system, a latency in transportation of an analyte between first and second physiological compartments, based, at least in part, upon at least one blood glucose reference sample;
compensating for the latency in estimating a concentration of the analyte in the first physiological compartment based, at least in part, on one or more observations of a concentration of the analyte in the second physiological compartment by;
accumulating over time a plurality of difference values between a sensor signal value and an offset value to provide an accumulation result;
combining a term with the accumulation result to provide a combined expression, wherein the term includes the estimated latency; and
determining the estimated concentration based, at least in part, on a computed rate of change in the combined expression; and
wherein the method further comprises generating, using the controller, a command to one or more infusion pumps based, at least in part, on the estimated concentration.
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Abstract
Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.
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Citations
16 Claims
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1. A method comprising:
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estimating, using a controller of a glucose control system, a latency in transportation of an analyte between first and second physiological compartments, based, at least in part, upon at least one blood glucose reference sample; compensating for the latency in estimating a concentration of the analyte in the first physiological compartment based, at least in part, on one or more observations of a concentration of the analyte in the second physiological compartment by; accumulating over time a plurality of difference values between a sensor signal value and an offset value to provide an accumulation result; combining a term with the accumulation result to provide a combined expression, wherein the term includes the estimated latency; and determining the estimated concentration based, at least in part, on a computed rate of change in the combined expression; and wherein the method further comprises generating, using the controller, a command to one or more infusion pumps based, at least in part, on the estimated concentration. - View Dependent Claims (2, 3, 4, 5, 6)
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7. An apparatus for use with at least one blood glucose reference sample and for use with one or more infusion pumps, the apparatus comprising:
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a sensor configured to generate a signal responsive to a concentration of an analyte in a second physiological compartment; and a processor configured to; estimate a latency in transportation of the analyte between a first physiological compartment and the second physiological compartment, based, at least in part, upon the at least one blood glucose reference sample; and compensate for the latency in estimating a concentration of the analyte in the first physiological compartment based, at least in part, on the signal responsive to the concentration of the analyte in the second physiological compartment by; accumulating over time a plurality of difference values between the signal generated by the sensor and an offset value to provide an accumulation result; combining a term with the accumulation result to provide a combined expression, wherein the term includes the estimated latency; and determining the estimated concentration based, at least in part, on a computed rate of change in the combined expression, wherein the processor is further configured to generate a command to the one or more infusion pumps based, at least in part, on the estimated concentration. - View Dependent Claims (8, 9, 10, 11, 12)
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13. An article for use with at least one blood glucose reference sample and for use with one or more infusion pumps, the article comprising:
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a non-transitory storage medium having machine-readable instructions stored thereon which are executable by a special purpose computing apparatus to; estimate a latency in transportation of an analyte between first and second physiological compartments, based, at least in part, upon the at least one blood glucose reference sample; and compensate for the latency in estimating a concentration of the analyte in the first physiological compartment based, at least in part, on one or more measurements of a concentration of the analyte in the second physiological compartment by; accumulating over time a plurality of difference values between a sensor signal value and an offset value to provide an accumulation result; combining a term with the accumulation result to provide a combined expression, wherein the term includes the estimated latency; and determining the estimated concentration based, at least in part, on a computed rate of change in the combined expression, wherein the instructions are further executable by the special purpose computing apparatus to generate a command to the one or more infusion pumps based, at least in part, on the estimated concentration. - View Dependent Claims (14, 15, 16)
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Specification