Dialysis system including heparin injection

• US 9,855,377 B2
• Filed: 01/12/2015
• Issued: 01/02/2018
• Est. Priority Date: 10/24/2007
• Status: Active Grant

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Childers, Robert W., Kelly, Thomas D., Roger, Rodolfo
• Primary Examiner(s): DRODGE, JOSEPH W
• Application Number:
  US14/594,349
• Publication Number:
  US 20150122721A1
• Time in Patent Office: 1,086 Days
• Field of Search: 210175, 210180, 210188, 2101952, 2103216, 21032171, 210646, 210647, 210805, 210806, 95241, 95251, 95259, 96155, 96218, 604 401, 604 501, 604 601, 604 609, 604 611, 604 19, 604 27- 30, 604122, 604123, 514893, 514894
• CPC Class Codes: A61M 1/14 Dialysis systems; Artificial kidneys; Blood oxygenators semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00 ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/1524 the interface providing means for actuating on functional elements of the cassette, e.g. plungers
• CPC Class Codes: A61M 1/153 the cassette being adapted for heating or cooling the treating fluid, e.g. the dialysate or the treating gas
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/1561 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/15625 the reservoirs acting as balance chambers
• CPC Class Codes: A61M 1/1565 Details of valves
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1601 Control or regulation
• CPC Class Codes: A61M 1/1605 Physical characteristics of the dialysate fluid
• CPC Class Codes: A61M 1/1621 Constructional aspects thereof semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi permeable membranes characterised by their material B01D71/00
• CPC Class Codes: A61M 1/1635 with volume chamber balancing devices between used and fresh dialysis fluid
• CPC Class Codes: A61M 1/1649 with pulsatile dialysis fluid flow
• CPC Class Codes: A61M 1/166 Heating for sterilisation A61M1/1686
• CPC Class Codes: A61M 1/168 Sterilisation or cleaning before or after use
• CPC Class Codes: A61M 1/1686 by heat
• CPC Class Codes: A61M 1/1688 with recirculation of the sterilising fluid
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/281 Instillation other than by gravity
• CPC Class Codes: A61M 1/3465 using dialysate as substitution fluid
• CPC Class Codes: A61M 1/362227 : the interface providing means for actuating on functional elements of the cassette, e.g. plungers
• CPC Class Codes: A61M 1/36225 : with blood pumping means or components thereof
• CPC Class Codes: A61M 1/362261 : at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/362262 : Details of incorporated reservoirs
• CPC Class Codes: A61M 1/362265 : Details of valves
• CPC Class Codes: A61M 1/3643 : Priming, rinsing before or after use
• CPC Class Codes: A61M 1/3644 : Mode of operation
• CPC Class Codes: A61M 1/3649 : using dialysate as priming or rinsing liquid
• CPC Class Codes: A61M 1/3652 : using gas, e.g. air
• CPC Class Codes: A61M 2205/128 : with incorporated valves
• CPC Class Codes: A61M 2205/14 : Detection of the presence or absence of a tube, a connector or a container in an apparatus
• CPC Class Codes: A61M 2205/3313 : used specific wavelengths
• CPC Class Codes: A61M 2205/3331 : Pressure; Flow
• CPC Class Codes: A61M 2205/3334 : Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3344 : Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2205/3379 : Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: A61M 2205/6036 : characterised by physical shape, e.g. array of activating switches
• CPC Class Codes: B01D 61/244 : comprising multiple dialysis steps
• CPC Class Codes: B01D 61/30 : Accessories; Auxiliary operation
• CPC Class Codes: Y10T 137/0396 : Involving pressure control
• CPC Class Codes: Y10T 137/87893 : With fluid actuator
• CPC Class Codes: Y10T 29/49826 : Assembling or joining

Abstract

A dialysis system includes a dialysis instrument including a blood pump actuator, a dialyzer, a heparin pump, and a disposable cassette including a blood pumping portion operable with the blood pump actuator of the dialysis instrument, the blood pumping portion including an inlet and an outlet, the inlet of the blood pumping portion of the disposable cassette positioned and arranged to receive blood from an arterial line of an extracorporeal circuit, the outlet of the blood pumping portion of the disposable cassette positioned and arranged to deliver the blood to the dialyzer and to receive heparin from the heparin pump.

Claims

1. A dialysis system comprising:

a dialysis instrument including a blood pump actuator;

an extracorporeal circuit including a dialyzer;

a heparin pump;

a disposable cassette including a blood pumping portion operable with the blood pump actuator of the dialysis instrument to cause blood to be pumped through the extracorporeal circuit, the blood pumping portion including an inlet and an outlet, the inlet of the blood pumping portion of the disposable cassette positioned and arranged to receive blood from an arterial line of the extracorporeal circuit, the outlet of the blood pumping portion of the disposable cassette positioned and arranged to deliver the blood to the dialyzer and to receive heparin from the heparin pump at a heparin introduction location to the disposable cassette; and

a saline source configured to deliver saline to the extracorporeal circuit at a saline introduction location to the disposable cassette, and wherein the saline introduction location is adjacent to the heparin introduction location.

2. The dialysis system of claim 1, wherein the heparin pump is positioned and arranged to introduce the heparin into the outlet of the blood pumping portion just prior to a disposable cassette inlet to the dialyzer.

3. The dialysis system of claim 1, wherein the heparin pump includes a tube positioned to introduce the heparin into the outlet of the blood pumping portion of the disposable cassette.

4. The dialysis system of claim 3, wherein the dialysis instrument includes a pinch valve operable with the tube to control the heparin introduced into the outlet of the blood pumping portion.

5. The dialysis system of claim 3, which includes an air bubble detector, wherein heparin in the tube passes through the air bubble detector before reaching the disposable cassette.

6. The dialysis system of claim 1, wherein the heparin pump includes a syringe pointed downwardly so that air collects above the heparin within the syringe.

7. The dialysis system of claim 1, wherein the heparin pump accepts a syringe ranging in size from ten millimeters to sixty millimeters.

8. The dialysis system of claim 1, wherein the heparin pump includes a syringe located within a housing of the dialysis instrument.

9. The dialysis system of claim 8, wherein the syringe is a smaller syringe, and wherein the dialysis instrument is configured to accommodate heparin syringes, larger than said heparin pump syringe, located at least partly outside of the dialysis instrument housing.

10. A dialysis system comprising:

a dialysis instrument including a blood pump actuator;

an extracorporeal circuit including a dialyzer;

a heparin source;

a saline source; and

a disposable cassette including a blood pumping portion operable with the blood pump actuator of the dialysis instrument to cause blood to be pumped through the extracorporeal circuit, the disposable cassette placing the blood pumping portion in fluid communication with the dialyzer and the extracorporeal circuit, so that blood can be pumped from the extracorporeal circuit, through the blood pumping portion, to the dialyzer,

wherein the disposable cassette is configured to (i) introduce heparin from the heparin source into the blood at a first location of the disposable cassette between the blood pumping portion and the dialyzer, and (ii) introduce saline from the saline source into the extracorporeal circuit at a second location of the disposable cassette, and wherein the second location is adjacent to the first location for introduction of heparin.

11. The dialysis system of claim 10, wherein the disposable cassette is configured to introduce the heparin into the disposable cassette just prior to an inlet of the dialyzer.

12. The dialysis system of claim 10, wherein the disposable cassette is configured to introduce heparin into the disposable cassette at an outlet of the blood pumping portion.

13. The dialysis system of claim 10, wherein the disposable cassette accepts a tube extending from the heparin source.

14. The dialysis system of claim 13, which includes an air detector, wherein the tube is fitted into the air detector.

15. The dialysis system of claim 10, wherein the heparin source includes a syringe pump.

16. A dialysis system comprising:

a dialysis instrument including a blood pump actuator;

an extracorporeal circuit including a dialyzer;

a disposable cassette including a blood pumping portion operable with the blood pump actuator of the dialysis instrument to cause blood to be pumped through the extracorporeal circuit, the disposable cassette placing the blood pumping portion in fluid communication with the dialyzer and the extracorporeal circuit, so that blood can be pumped from the extracorporeal circuit, through the blood pumping portion, to the dialyzer;

a heparin source comprising a syringe in fluid communication with the disposable cassette via a tube; and

an air detector operably connected to the tube configured such that air exits the syringe during priming of the extracorporeal circuit.

17. The dialysis system of claim 16, wherein the disposable cassette is configured to accept the tube just prior to an inlet to the dialyzer.

18. The dialysis system of claim 16, wherein the disposable cassette is configured to accept the tube at an outlet of the blood pumping portion.

19. The dialysis system of claim 16, wherein the heparin source includes a syringe pointed downwardly so that air collects above heparin within the syringe.

20. A dialysis system comprising:

a dialysis instrument including a blood pump actuator and a syringe pump actuator;

an extracorporeal circuit including a dialyzer;

a disposable cassette including a blood pumping portion operable with the blood pump actuator of the dialysis instrument to cause blood to be pumped through the extracorporeal circuit, the disposable cassette placing the blood pumping portion in fluid communication with the dialyzer and the extracorporeal circuit, so that blood can be pumped from the extracorporeal circuit, through the blood pumping portion, to the dialyzer; and

a heparin source in fluid communication with the disposable cassette, the heparin source including a syringe having a plunger pointed downwardly into the syringe pump actuator and a barrel pointed upwardly into a heparin discharge tube.